8YWQ

Crystal structure of the Fab fragment of the anti-IL-6 antibody I9H in complex with a domain-swapped IL-6 dimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005138	molecular_function	interleukin-6 receptor binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006955	biological_process	immune response
A	0030154	biological_process	cell differentiation

Functional Information from PROSITE/UniProt

site_id	PS00254
Number of Residues	26
Details	INTERLEUKIN_6 Interleukin-6 / G-CSF / MGF signature. CfqsgfneetClvkiitGLleFevyL

Chain	Residue	Details
A	CYS73-LEU98

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR192-HIS198
H	TYR205-HIS211

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