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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8YU7

Cryo-EM structure of CXCR4 tetramer

Functional Information from GO Data
ChainGOidnamespacecontents
A0001618molecular_functionvirus receptor activity
A0001666biological_processresponse to hypoxia
A0002407biological_processdendritic cell chemotaxis
A0003779molecular_functionactin binding
A0004930molecular_functionG protein-coupled receptor activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005886cellular_componentplasma membrane
A0006915biological_processapoptotic process
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007420biological_processbrain development
A0009615biological_processresponse to virus
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0015026molecular_functioncoreceptor activity
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0016493molecular_functionC-C chemokine receptor activity
A0016494molecular_functionC-X-C chemokine receptor activity
A0019722biological_processcalcium-mediated signaling
A0019957molecular_functionC-C chemokine binding
A0022008biological_processneurogenesis
A0030155biological_processregulation of cell adhesion
A0030334biological_processregulation of cell migration
A0030335biological_processpositive regulation of cell migration
A0031252cellular_componentcell leading edge
A0031410cellular_componentcytoplasmic vesicle
A0031625molecular_functionubiquitin protein ligase binding
A0032027molecular_functionmyosin light chain binding
A0032991cellular_componentprotein-containing complex
A0038147molecular_functionC-X-C motif chemokine 12 receptor activity
A0038160biological_processCXCL12-activated CXCR4 signaling pathway
A0043130molecular_functionubiquitin binding
A0043217biological_processmyelin maintenance
A0046718biological_processsymbiont entry into host cell
A0048714biological_processpositive regulation of oligodendrocyte differentiation
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
A0070098biological_processchemokine-mediated signaling pathway
A0070161cellular_componentanchoring junction
A0071345biological_processcellular response to cytokine stimulus
A0120162biological_processpositive regulation of cold-induced thermogenesis
A1904018biological_processpositive regulation of vasculature development
A2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
B0001618molecular_functionvirus receptor activity
B0001666biological_processresponse to hypoxia
B0002407biological_processdendritic cell chemotaxis
B0003779molecular_functionactin binding
B0004930molecular_functionG protein-coupled receptor activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005770cellular_componentlate endosome
B0005886cellular_componentplasma membrane
B0006915biological_processapoptotic process
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0007420biological_processbrain development
B0009615biological_processresponse to virus
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0015026molecular_functioncoreceptor activity
B0016020cellular_componentmembrane
B0016477biological_processcell migration
B0016493molecular_functionC-C chemokine receptor activity
B0016494molecular_functionC-X-C chemokine receptor activity
B0019722biological_processcalcium-mediated signaling
B0019957molecular_functionC-C chemokine binding
B0022008biological_processneurogenesis
B0030155biological_processregulation of cell adhesion
B0030334biological_processregulation of cell migration
B0030335biological_processpositive regulation of cell migration
B0031252cellular_componentcell leading edge
B0031410cellular_componentcytoplasmic vesicle
B0031625molecular_functionubiquitin protein ligase binding
B0032027molecular_functionmyosin light chain binding
B0032991cellular_componentprotein-containing complex
B0038147molecular_functionC-X-C motif chemokine 12 receptor activity
B0038160biological_processCXCL12-activated CXCR4 signaling pathway
B0043130molecular_functionubiquitin binding
B0043217biological_processmyelin maintenance
B0046718biological_processsymbiont entry into host cell
B0048714biological_processpositive regulation of oligodendrocyte differentiation
B0060326biological_processcell chemotaxis
B0070062cellular_componentextracellular exosome
B0070098biological_processchemokine-mediated signaling pathway
B0070161cellular_componentanchoring junction
B0071345biological_processcellular response to cytokine stimulus
B0120162biological_processpositive regulation of cold-induced thermogenesis
B1904018biological_processpositive regulation of vasculature development
B2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
C0001618molecular_functionvirus receptor activity
C0001666biological_processresponse to hypoxia
C0002407biological_processdendritic cell chemotaxis
C0003779molecular_functionactin binding
C0004930molecular_functionG protein-coupled receptor activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005768cellular_componentendosome
C0005769cellular_componentearly endosome
C0005770cellular_componentlate endosome
C0005886cellular_componentplasma membrane
C0006915biological_processapoptotic process
C0006954biological_processinflammatory response
C0006955biological_processimmune response
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
C0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007420biological_processbrain development
C0009615biological_processresponse to virus
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0015026molecular_functioncoreceptor activity
C0016020cellular_componentmembrane
C0016477biological_processcell migration
C0016493molecular_functionC-C chemokine receptor activity
C0016494molecular_functionC-X-C chemokine receptor activity
C0019722biological_processcalcium-mediated signaling
C0019957molecular_functionC-C chemokine binding
C0022008biological_processneurogenesis
C0030155biological_processregulation of cell adhesion
C0030334biological_processregulation of cell migration
C0030335biological_processpositive regulation of cell migration
C0031252cellular_componentcell leading edge
C0031410cellular_componentcytoplasmic vesicle
C0031625molecular_functionubiquitin protein ligase binding
C0032027molecular_functionmyosin light chain binding
C0032991cellular_componentprotein-containing complex
C0038147molecular_functionC-X-C motif chemokine 12 receptor activity
C0038160biological_processCXCL12-activated CXCR4 signaling pathway
C0043130molecular_functionubiquitin binding
C0043217biological_processmyelin maintenance
C0046718biological_processsymbiont entry into host cell
C0048714biological_processpositive regulation of oligodendrocyte differentiation
C0060326biological_processcell chemotaxis
C0070062cellular_componentextracellular exosome
C0070098biological_processchemokine-mediated signaling pathway
C0070161cellular_componentanchoring junction
C0071345biological_processcellular response to cytokine stimulus
C0120162biological_processpositive regulation of cold-induced thermogenesis
C1904018biological_processpositive regulation of vasculature development
C2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
D0001618molecular_functionvirus receptor activity
D0001666biological_processresponse to hypoxia
D0002407biological_processdendritic cell chemotaxis
D0003779molecular_functionactin binding
D0004930molecular_functionG protein-coupled receptor activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005768cellular_componentendosome
D0005769cellular_componentearly endosome
D0005770cellular_componentlate endosome
D0005886cellular_componentplasma membrane
D0006915biological_processapoptotic process
D0006954biological_processinflammatory response
D0006955biological_processimmune response
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
D0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0007420biological_processbrain development
D0009615biological_processresponse to virus
D0009897cellular_componentexternal side of plasma membrane
D0009986cellular_componentcell surface
D0015026molecular_functioncoreceptor activity
D0016020cellular_componentmembrane
D0016477biological_processcell migration
D0016493molecular_functionC-C chemokine receptor activity
D0016494molecular_functionC-X-C chemokine receptor activity
D0019722biological_processcalcium-mediated signaling
D0019957molecular_functionC-C chemokine binding
D0022008biological_processneurogenesis
D0030155biological_processregulation of cell adhesion
D0030334biological_processregulation of cell migration
D0030335biological_processpositive regulation of cell migration
D0031252cellular_componentcell leading edge
D0031410cellular_componentcytoplasmic vesicle
D0031625molecular_functionubiquitin protein ligase binding
D0032027molecular_functionmyosin light chain binding
D0032991cellular_componentprotein-containing complex
D0038147molecular_functionC-X-C motif chemokine 12 receptor activity
D0038160biological_processCXCL12-activated CXCR4 signaling pathway
D0043130molecular_functionubiquitin binding
D0043217biological_processmyelin maintenance
D0046718biological_processsymbiont entry into host cell
D0048714biological_processpositive regulation of oligodendrocyte differentiation
D0060326biological_processcell chemotaxis
D0070062cellular_componentextracellular exosome
D0070098biological_processchemokine-mediated signaling pathway
D0070161cellular_componentanchoring junction
D0071345biological_processcellular response to cytokine stimulus
D0120162biological_processpositive regulation of cold-induced thermogenesis
D1904018biological_processpositive regulation of vasculature development
D2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSVlILAFISLDRYLaI
ChainResidueDetails
ASER122-ILE138
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues240
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues200
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues12
DetailsRegion: {"description":"Chemokine binding","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10825158","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues16
DetailsRegion: {"description":"Chemokine binding"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues48
DetailsRegion: {"description":"Involved in dimerization; when bound to chemokine"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues16
DetailsRegion: {"description":"Chemokine binding, important for signaling and HIV-1 coreceptor activity"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues84
DetailsRegion: {"description":"Involved in dimerization"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues8
DetailsMotif: {"description":"Important for signaling"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsSite: {"description":"Chemokine binding"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsSite: {"description":"Chemokine binding","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10825158","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-07-23

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