8YT8
Cryo-EM structure of the dystrophin glycoprotein complex
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0016012 | cellular_component | sarcoglycan complex |
| A | 0016020 | cellular_component | membrane |
| B | 0007517 | biological_process | muscle organ development |
| B | 0016012 | cellular_component | sarcoglycan complex |
| B | 0016020 | cellular_component | membrane |
| D | 0003015 | biological_process | heart process |
| D | 0005515 | molecular_function | protein binding |
| D | 0005856 | cellular_component | cytoskeleton |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0016010 | cellular_component | dystrophin-associated glycoprotein complex |
| D | 0016011 | cellular_component | dystroglycan complex |
| D | 0016012 | cellular_component | sarcoglycan complex |
| D | 0016020 | cellular_component | membrane |
| D | 0016529 | cellular_component | sarcoplasmic reticulum |
| D | 0019722 | biological_process | calcium-mediated signaling |
| D | 0031503 | biological_process | protein-containing complex localization |
| D | 0042383 | cellular_component | sarcolemma |
| D | 0048738 | biological_process | cardiac muscle tissue development |
| D | 0055013 | biological_process | cardiac muscle cell development |
| D | 0055074 | biological_process | calcium ion homeostasis |
| D | 0060047 | biological_process | heart contraction |
| D | 0060048 | biological_process | cardiac muscle contraction |
| D | 0060977 | biological_process | coronary vasculature morphogenesis |
| D | 0061024 | biological_process | membrane organization |
| D | 0086003 | biological_process | cardiac muscle cell contraction |
| E | 0008270 | molecular_function | zinc ion binding |
| G | 0005515 | molecular_function | protein binding |
| G | 0005856 | cellular_component | cytoskeleton |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0010467 | biological_process | gene expression |
| G | 0016011 | cellular_component | dystroglycan complex |
| G | 0016012 | cellular_component | sarcoglycan complex |
| G | 0016020 | cellular_component | membrane |
| G | 0042383 | cellular_component | sarcolemma |
| G | 0048738 | biological_process | cardiac muscle tissue development |
| G | 0060047 | biological_process | heart contraction |
| G | 0061024 | biological_process | membrane organization |
| O | 0005509 | molecular_function | calcium ion binding |
| O | 0016010 | cellular_component | dystrophin-associated glycoprotein complex |
| O | 0016020 | cellular_component | membrane |
| S | 0005886 | cellular_component | plasma membrane |
| S | 0016010 | cellular_component | dystrophin-associated glycoprotein complex |
| S | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS01357 |
| Number of Residues | 28 |
| Details | ZF_ZZ_1 Zinc finger ZZ-type signature. CniCkecpiigfRYrSlk...HfNYdICqsC |
| Chain | Residue | Details |
| E | CYS3306-CYS3333 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 892 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 120 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 58 |
| Details | Transmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 56 |
| Details | Zinc finger: {"description":"ZZ-type; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00228","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00228","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 109 |
| Details | Domain: {"description":"Peptidase S72"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by autolysis","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by MMP9","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 14 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
