8YO4

structure of phage T4 topoisomerase II central domain bound with DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000819	biological_process	sister chromatid segregation
A	0003677	molecular_function	DNA binding
A	0003916	molecular_function	DNA topoisomerase activity
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change
A	0016853	molecular_function	isomerase activity
A	0032991	cellular_component	protein-containing complex
B	0000166	molecular_function	nucleotide binding
B	0000819	biological_process	sister chromatid segregation
B	0003677	molecular_function	DNA binding
B	0003916	molecular_function	DNA topoisomerase activity
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0006259	biological_process	DNA metabolic process
B	0006265	biological_process	DNA topological change
B	0016853	molecular_function	isomerase activity
B	0032991	cellular_component	protein-containing complex
C	0000166	molecular_function	nucleotide binding
C	0000819	biological_process	sister chromatid segregation
C	0003677	molecular_function	DNA binding
C	0003916	molecular_function	DNA topoisomerase activity
C	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
C	0005524	molecular_function	ATP binding
C	0006265	biological_process	DNA topological change
C	0016853	molecular_function	isomerase activity
C	0032991	cellular_component	protein-containing complex
D	0000166	molecular_function	nucleotide binding
D	0000819	biological_process	sister chromatid segregation
D	0003677	molecular_function	DNA binding
D	0003916	molecular_function	DNA topoisomerase activity
D	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0006265	biological_process	DNA topological change
D	0016853	molecular_function	isomerase activity
D	0032991	cellular_component	protein-containing complex

Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSAIG

Chain	Residue	Details
C	LEU413-GLY421

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	818
Details	Domain: {"description":"Topo IIA-type catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU01384","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01384","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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