8YGW
The Crystal Structure of MAPK11 from Biortus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001649 | biological_process | osteoblast differentiation |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004707 | molecular_function | MAP kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0031098 | biological_process | stress-activated protein kinase signaling cascade |
| A | 0032735 | biological_process | positive regulation of interleukin-12 production |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0038066 | biological_process | p38MAPK cascade |
| A | 0045648 | biological_process | positive regulation of erythrocyte differentiation |
| A | 0051149 | biological_process | positive regulation of muscle cell differentiation |
| A | 0051403 | biological_process | stress-activated MAPK cascade |
| A | 0060348 | biological_process | bone development |
| A | 0071347 | biological_process | cellular response to interleukin-1 |
| A | 0071493 | biological_process | cellular response to UV-B |
| A | 0090398 | biological_process | cellular senescence |
| A | 0098586 | biological_process | cellular response to virus |
| A | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCsAydarlrqkv.........AVKK |
| Chain | Residue | Details |
| A | VAL30-LYS54 |
| site_id | PS01351 |
| Number of Residues | 104 |
| Details | MAPK MAP kinase signature. FqsliharrtyRElrllkhlkhenviglldvftpatsiedfsevylvttlmgadlnnivkcqalsdehvqflvyqllrglkyihsagiih.........RDlKpsnvavnedC |
| Chain | Residue | Details |
| A | PHE59-CYS162 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Compositional bias: {"description":"Acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by ZAP70","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
