8YGW
The Crystal Structure of MAPK11 from Biortus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0001649 | biological_process | osteoblast differentiation |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004707 | molecular_function | MAP kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0031098 | biological_process | stress-activated protein kinase signaling cascade |
| A | 0032735 | biological_process | positive regulation of interleukin-12 production |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0038066 | biological_process | p38MAPK cascade |
| A | 0045648 | biological_process | positive regulation of erythrocyte differentiation |
| A | 0051149 | biological_process | positive regulation of muscle cell differentiation |
| A | 0051403 | biological_process | stress-activated MAPK cascade |
| A | 0060038 | biological_process | cardiac muscle cell proliferation |
| A | 0060043 | biological_process | regulation of cardiac muscle cell proliferation |
| A | 0060044 | biological_process | negative regulation of cardiac muscle cell proliferation |
| A | 0060348 | biological_process | bone development |
| A | 0071347 | biological_process | cellular response to interleukin-1 |
| A | 0071493 | biological_process | cellular response to UV-B |
| A | 0090398 | biological_process | cellular senescence |
| A | 0098586 | biological_process | cellular response to virus |
| A | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCsAydarlrqkv.........AVKK |
| Chain | Residue | Details |
| A | VAL30-LYS54 |
| site_id | PS01351 |
| Number of Residues | 104 |
| Details | MAPK MAP kinase signature. FqsliharrtyRElrllkhlkhenviglldvftpatsiedfsevylvttlmgadlnnivkcqalsdehvqflvyqllrglkyihsagiih.........RDlKpsnvavnedC |
| Chain | Residue | Details |
| A | PHE59-CYS162 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | ASP150 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | VAL30 | |
| A | LYS53 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLU71 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by MAP2K3, MAP2K4 and MAP2K6 => ECO:0000305|PubMed:15356147 |
| Chain | Residue | Details |
| A | THR180 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by MAP2K3, MAP2K4 and MAP2K6 => ECO:0000305|PubMed:15356147 |
| Chain | Residue | Details |
| A | TYR182 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by ZAP70 => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR323 |
