8YB5
SARS-CoV-2 DMV nsp3-4 pore complex (consensus-pore, C6 symmetry)
Functional Information from PROSITE/UniProt
| site_id | PS00867 |
| Number of Residues | 8 |
| Details | CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. VLECNVKT |
| Chain | Residue | Details |
| A | VAL1243-THR1250 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| C | VAL13-MET33 | |
| C | ALA282-MET302 | |
| C | PHE337-VAL357 | |
| C | TRP365-ILE385 | |
| D | VAL13-MET33 | |
| D | ALA282-MET302 | |
| D | PHE337-VAL357 | |
| D | TRP365-ILE385 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 506 |
| Details | TOPO_DOM: Lumenal => ECO:0000305 |
| Chain | Residue | Details |
| C | SER34-SER281 | |
| C | SER358-GLN364 | |
| D | SER34-SER281 | |
| D | SER358-GLN364 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 66 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| C | ARG303-SER336 | |
| D | ARG303-SER336 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
| Chain | Residue | Details |
| C | GLN500 | |
| D | GLN500 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | ACT_SITE: For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444 |
| Chain | Residue | Details |
| A | HIS1017 | |
| A | ASP1031 | |
| B | HIS1017 | |
| B | ASP1031 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00444 |
| Chain | Residue | Details |
| A | CYS934 | |
| A | CYS937 | |
| A | CYS969 | |
| A | CYS971 | |
| B | CYS934 | |
| B | CYS937 | |
| B | CYS969 | |
| B | CYS971 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01336 |
| Chain | Residue | Details |
| A | HIS1581 | |
| B | CYS1586 | |
| B | CYS1591 | |
| B | CYS1594 | |
| B | CYS1627 | |
| B | HIS1630 | |
| B | CYS1634 | |
| B | CYS1637 | |
| A | CYS1586 | |
| A | CYS1591 | |
| A | CYS1594 | |
| A | CYS1627 | |
| A | HIS1630 | |
| A | CYS1634 | |
| A | CYS1637 | |
| B | HIS1581 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by PL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
| Chain | Residue | Details |
| A | GLY1945 | |
| B | GLY1945 |
