8Y8V
Cryo-EM structure of AQP7 in POPC nanodisc
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005811 | cellular_component | lipid droplet |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005911 | cellular_component | cell-cell junction |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0006833 | biological_process | water transport |
| A | 0008218 | biological_process | bioluminescence |
| A | 0015204 | molecular_function | urea transmembrane transporter activity |
| A | 0015250 | molecular_function | water channel activity |
| A | 0015254 | molecular_function | glycerol channel activity |
| A | 0015267 | molecular_function | channel activity |
| A | 0015793 | biological_process | glycerol transmembrane transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071918 | biological_process | urea transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 69 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 26 |
| Details | Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Motif: {"description":"NPA 1","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Motif: {"description":"NPA 2","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | Site: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for permeability to glycerol","evidences":[{"source":"PubMed","id":"30423801","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
