8Y6F

The crystal structure of MMPs cleavable human heavy chain ferritin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0008199	molecular_function	ferric iron binding
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0008199	molecular_function	ferric iron binding
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0008199	molecular_function	ferric iron binding
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0008199	molecular_function	ferric iron binding
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0008199	molecular_function	ferric iron binding
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0008199	molecular_function	ferric iron binding
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0008199	molecular_function	ferric iron binding
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0008199	molecular_function	ferric iron binding
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0008199	molecular_function	ferric iron binding
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0008199	molecular_function	ferric iron binding
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0008199	molecular_function	ferric iron binding
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0008199	molecular_function	ferric iron binding

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFIEthYLneqvkaIK

Chain	Residue	Details
A	ASP127-LYS147

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site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EeREhaEKLMklQNqRgGR

Chain	Residue	Details
A	GLU62-ARG80

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:1992356, ECO:0007744|PDB:1FHA

Chain	Residue	Details
A	GLU28
E	HIS66
F	GLU28
F	HIS66
G	GLU28
G	HIS66
H	GLU28
H	HIS66
I	GLU28
I	HIS66
J	GLU28
A	HIS66
J	HIS66
K	GLU28
K	HIS66
L	GLU28
L	HIS66
B	GLU28
B	HIS66
C	GLU28
C	HIS66
D	GLU28
D	HIS66
E	GLU28

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00085

Chain	Residue	Details
A	GLU63
D	GLU63
D	GLU108
D	GLN142
E	GLU63
E	GLU108
E	GLN142
F	GLU63
F	GLU108
F	GLN142
G	GLU63
A	GLU108
G	GLU108
G	GLN142
H	GLU63
H	GLU108
H	GLN142
I	GLU63
I	GLU108
I	GLN142
J	GLU63
J	GLU108
A	GLN142
J	GLN142
K	GLU63
K	GLU108
K	GLN142
L	GLU63
L	GLU108
L	GLN142
B	GLU63
B	GLU108
B	GLN142
C	GLU63
C	GLU108
C	GLN142

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	SITE: Essential for association with cargo receptor NCOA4 => ECO:0000269|PubMed:26436293

Chain	Residue	Details
A	ARG23
J	ARG23
K	ARG23
L	ARG23
B	ARG23
C	ARG23
D	ARG23
E	ARG23
F	ARG23
G	ARG23
H	ARG23
I	ARG23

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	MET1
J	MET1
K	MET1
L	MET1
B	MET1
C	MET1
D	MET1
E	MET1
F	MET1
G	MET1
H	MET1
I	MET1

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	MOD_RES: N-acetylthreonine; in Ferritin heavy chain, N-terminally processed => ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	THR2
J	THR2
K	THR2
L	THR2
B	THR2
C	THR2
D	THR2
E	THR2
F	THR2
G	THR2
H	THR2
I	THR2

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER186
J	SER186
K	SER186
L	SER186
B	SER186
C	SER186
D	SER186
E	SER186
F	SER186
G	SER186
H	SER186
I	SER186

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