8Y6F
The crystal structure of MMPs cleavable human heavy chain ferritin
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:1992356, ECO:0007744|PDB:1FHA |
| Chain | Residue | Details |
| A | GLU28 | |
| E | HIS66 | |
| F | GLU28 | |
| F | HIS66 | |
| G | GLU28 | |
| G | HIS66 | |
| H | GLU28 | |
| H | HIS66 | |
| I | GLU28 | |
| I | HIS66 | |
| J | GLU28 | |
| A | HIS66 | |
| J | HIS66 | |
| K | GLU28 | |
| K | HIS66 | |
| L | GLU28 | |
| L | HIS66 | |
| B | GLU28 | |
| B | HIS66 | |
| C | GLU28 | |
| C | HIS66 | |
| D | GLU28 | |
| D | HIS66 | |
| E | GLU28 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00085 |
| Chain | Residue | Details |
| A | GLU63 | |
| D | GLU63 | |
| D | GLU108 | |
| D | GLN142 | |
| E | GLU63 | |
| E | GLU108 | |
| E | GLN142 | |
| F | GLU63 | |
| F | GLU108 | |
| F | GLN142 | |
| G | GLU63 | |
| A | GLU108 | |
| G | GLU108 | |
| G | GLN142 | |
| H | GLU63 | |
| H | GLU108 | |
| H | GLN142 | |
| I | GLU63 | |
| I | GLU108 | |
| I | GLN142 | |
| J | GLU63 | |
| J | GLU108 | |
| A | GLN142 | |
| J | GLN142 | |
| K | GLU63 | |
| K | GLU108 | |
| K | GLN142 | |
| L | GLU63 | |
| L | GLU108 | |
| L | GLN142 | |
| B | GLU63 | |
| B | GLU108 | |
| B | GLN142 | |
| C | GLU63 | |
| C | GLU108 | |
| C | GLN142 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | SITE: Essential for association with cargo receptor NCOA4 => ECO:0000269|PubMed:26436293 |
| Chain | Residue | Details |
| A | ARG23 | |
| J | ARG23 | |
| K | ARG23 | |
| L | ARG23 | |
| B | ARG23 | |
| C | ARG23 | |
| D | ARG23 | |
| E | ARG23 | |
| F | ARG23 | |
| G | ARG23 | |
| H | ARG23 | |
| I | ARG23 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | MET1 | |
| J | MET1 | |
| K | MET1 | |
| L | MET1 | |
| B | MET1 | |
| C | MET1 | |
| D | MET1 | |
| E | MET1 | |
| F | MET1 | |
| G | MET1 | |
| H | MET1 | |
| I | MET1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | MOD_RES: N-acetylthreonine; in Ferritin heavy chain, N-terminally processed => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | THR2 | |
| J | THR2 | |
| K | THR2 | |
| L | THR2 | |
| B | THR2 | |
| C | THR2 | |
| D | THR2 | |
| E | THR2 | |
| F | THR2 | |
| G | THR2 | |
| H | THR2 | |
| I | THR2 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER186 | |
| J | SER186 | |
| K | SER186 | |
| L | SER186 | |
| B | SER186 | |
| C | SER186 | |
| D | SER186 | |
| E | SER186 | |
| F | SER186 | |
| G | SER186 | |
| H | SER186 | |
| I | SER186 |
