8Y5H

Cryo-EM structure of E.coli spermidine transporter PotD-PotABC in pre-translocation state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0015417	molecular_function	ABC-type polyamine transporter activity
A	0015594	molecular_function	ABC-type putrescine transporter activity
A	0015846	biological_process	polyamine transport
A	0015847	biological_process	putrescine transport
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0022857	molecular_function	transmembrane transporter activity
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0055085	biological_process	transmembrane transport
A	1903711	biological_process	spermidine transmembrane transport
B	0005886	cellular_component	plasma membrane
B	0015417	molecular_function	ABC-type polyamine transporter activity
B	0015847	biological_process	putrescine transport
B	0016020	cellular_component	membrane
B	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
B	0055085	biological_process	transmembrane transport
B	1903711	biological_process	spermidine transmembrane transport
C	0005886	cellular_component	plasma membrane
C	0015417	molecular_function	ABC-type polyamine transporter activity
C	0015847	biological_process	putrescine transport
C	0016020	cellular_component	membrane
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0055085	biological_process	transmembrane transport
C	1903711	biological_process	spermidine transmembrane transport
D	0000166	molecular_function	nucleotide binding
D	0005524	molecular_function	ATP binding
D	0005886	cellular_component	plasma membrane
D	0015417	molecular_function	ABC-type polyamine transporter activity
D	0015594	molecular_function	ABC-type putrescine transporter activity
D	0015846	biological_process	polyamine transport
D	0015847	biological_process	putrescine transport
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0022857	molecular_function	transmembrane transporter activity
D	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
D	0055085	biological_process	transmembrane transport
D	1903711	biological_process	spermidine transmembrane transport
E	0015846	biological_process	polyamine transport
E	0019808	molecular_function	polyamine binding
E	0042597	cellular_component	periplasmic space

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQQQRVAIARAV

Chain	Residue	Details
A	LEU148-VAL162

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	460
Details	Domain: {"description":"ABC transporter","evidences":[{"source":"HAMAP-Rule","id":"MF_01726","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01726","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	234
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	394
Details	Domain: {"description":"ABC transmembrane type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	172
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	78
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8897598","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---