8Y2O

The Cryo-EM structure of human tRNA methyltransferase FTSJ1-THADA with substrate tRNA and S-adenosyl homocysteine (SAH)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002128	biological_process	tRNA nucleoside ribose methylation
A	0005515	molecular_function	protein binding
A	0008033	biological_process	tRNA processing
A	0030234	molecular_function	enzyme regulator activity
A	0030488	biological_process	tRNA methylation
A	0032471	biological_process	negative regulation of endoplasmic reticulum calcium ion concentration
A	0055088	biological_process	lipid homeostasis
A	0098554	cellular_component	cytoplasmic side of endoplasmic reticulum membrane
A	1990845	biological_process	adaptive thermogenesis
B	0001510	biological_process	RNA methylation
B	0002128	biological_process	tRNA nucleoside ribose methylation
B	0002130	biological_process	wobble position ribose methylation
B	0002181	biological_process	cytoplasmic translation
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006400	biological_process	tRNA modification
B	0008033	biological_process	tRNA processing
B	0008168	molecular_function	methyltransferase activity
B	0008175	molecular_function	tRNA methyltransferase activity
B	0016423	molecular_function	tRNA (guanine) methyltransferase activity
B	0016740	molecular_function	transferase activity
B	0022008	biological_process	neurogenesis
B	0030488	biological_process	tRNA methylation
B	0032259	biological_process	methylation
B	0106050	molecular_function	tRNA 2'-O-methyltransferase activity
B	0106339	molecular_function	tRNA (cytidine(32)-2'-O)-methyltransferase activity
B	0106340	molecular_function	tRNA (guanosine(34)-2'-O)-methyltransferase activity
B	1904047	molecular_function	S-adenosyl-L-methionine binding

Functional Information from PROSITE/UniProt

site_id	PS01005
Number of Residues	10
Details	FORMATE_NITRITE_TP_1 Formate and nitrite transporters signature 1. IIsGSELITG

Chain	Residue	Details
A	ILE1493-GLY1502

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_03162","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03162","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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