8XZ2

The structural model of a homodimeric D-Ala-D-Ala metallopeptidase, VanX, from vancomycin-resistant bacteria

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
B	0016805	molecular_function	dipeptidase activity
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
B	0071555	biological_process	cell wall organization
B	0160237	molecular_function	D-Ala-D-Ala dipeptidase activity
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0008237	molecular_function	metallopeptidase activity
C	0008270	molecular_function	zinc ion binding
C	0016787	molecular_function	hydrolase activity
C	0016805	molecular_function	dipeptidase activity
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding
C	0071555	biological_process	cell wall organization
C	0160237	molecular_function	D-Ala-D-Ala dipeptidase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"9702193","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01924","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9702193","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 706

Chain

Residue

Details

---

site_id	MCSA2
Number of Residues	5
Details	M-CSA 706

Chain	Residue	Details
B	ARG71	electrostatic stabiliser
B	HIS116	metal ligand
B	ASP123	metal ligand
B	GLU181	proton acceptor, proton donor
B	HIS184	metal ligand

---