8XRP
The Cryo-EM structure of IL-12, receptor subunit beta-1 and receptor subunit beta-2 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005143 | molecular_function | interleukin-12 receptor binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006955 | biological_process | immune response |
| A | 0008083 | molecular_function | growth factor activity |
| B | 0004896 | molecular_function | cytokine receptor activity |
| B | 0016020 | cellular_component | membrane |
| E | 0005143 | molecular_function | interleukin-12 receptor binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0006955 | biological_process | immune response |
| E | 0008083 | molecular_function | growth factor activity |
| F | 0004896 | molecular_function | cytokine receptor activity |
| F | 0016020 | cellular_component | membrane |
| I | 0005143 | molecular_function | interleukin-12 receptor binding |
| I | 0005576 | cellular_component | extracellular region |
| I | 0006955 | biological_process | immune response |
| I | 0008083 | molecular_function | growth factor activity |
| J | 0004896 | molecular_function | cytokine receptor activity |
| J | 0016020 | cellular_component | membrane |
| M | 0005143 | molecular_function | interleukin-12 receptor binding |
| M | 0005576 | cellular_component | extracellular region |
| M | 0006955 | biological_process | immune response |
| M | 0008083 | molecular_function | growth factor activity |
| N | 0004896 | molecular_function | cytokine receptor activity |
| N | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00092 |
| Number of Residues | 7 |
| Details | N6_MTASE N-6 Adenine-specific DNA methylases signature. CFQDPPY |
| Chain | Residue | Details |
| D | CYS30-TYR36 |
| site_id | PS01354 |
| Number of Residues | 43 |
| Details | HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. IkPDPPknLqlkplknsrq.VevsWeyPdTWstphsyFsLtFcV |
| Chain | Residue | Details |
| B | ILE233-VAL275 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| D | ASN121 | |
| G | ASN271 | |
| K | ASN48 | |
| K | ASN129 | |
| K | ASN166 | |
| K | ASN195 | |
| K | ASN271 | |
| O | ASN48 | |
| O | ASN129 | |
| O | ASN166 | |
| O | ASN195 | |
| H | ASN121 | |
| O | ASN271 | |
| L | ASN121 | |
| P | ASN121 | |
| C | ASN271 | |
| G | ASN48 | |
| G | ASN129 | |
| G | ASN166 | |
| G | ASN195 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10899108 |
| Chain | Residue | Details |
| B | ASN222 | |
| F | ASN222 | |
| J | ASN222 | |
| N | ASN222 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | CARBOHYD: C-linked (Man) tryptophan => ECO:0000269|PubMed:10207176 |
| Chain | Residue | Details |
| B | TRP319 | |
| F | TRP319 | |
| J | TRP319 | |
| N | TRP319 |
