8XQR
Structure 2 of human class T GPCR TAS2R14-miniGs/gust complex with Flufenamic acid.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0019001 | molecular_function | guanyl nucleotide binding |
| A | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| B | 0001750 | cellular_component | photoreceptor outer segment |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0005834 | cellular_component | heterotrimeric G-protein complex |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| B | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| B | 0007213 | biological_process | G protein-coupled acetylcholine receptor signaling pathway |
| B | 0007265 | biological_process | Ras protein signal transduction |
| B | 0008283 | biological_process | cell population proliferation |
| B | 0016020 | cellular_component | membrane |
| B | 0030159 | molecular_function | signaling receptor complex adaptor activity |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045202 | cellular_component | synapse |
| B | 0050909 | biological_process | sensory perception of taste |
| B | 0051020 | molecular_function | GTPase binding |
| B | 0060041 | biological_process | retina development in camera-type eye |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| B | 0071870 | biological_process | cellular response to catecholamine stimulus |
| B | 0097381 | cellular_component | photoreceptor disc membrane |
| B | 1903561 | cellular_component | extracellular vesicle |
| C | 0005515 | molecular_function | protein binding |
| C | 0005834 | cellular_component | heterotrimeric G-protein complex |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0007165 | biological_process | signal transduction |
| C | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| C | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| C | 0016020 | cellular_component | membrane |
| C | 0031681 | molecular_function | G-protein beta-subunit binding |
| C | 0045202 | cellular_component | synapse |
| C | 0048144 | biological_process | fibroblast proliferation |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| C | 0071870 | biological_process | cellular response to catecholamine stimulus |
| R | 0001580 | biological_process | detection of chemical stimulus involved in sensory perception of bitter taste |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0007165 | biological_process | signal transduction |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0008527 | molecular_function | taste receptor activity |
| R | 0016020 | cellular_component | membrane |
| R | 0033038 | molecular_function | bitter taste receptor activity |
| R | 0050909 | biological_process | sensory perception of taste |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| B | LEU70-SER84 | |
| B | ILE157-ILE171 | |
| B | LEU285-ALA299 | |
| B | VAL327-GLY341 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P04896 |
| Chain | Residue | Details |
| A | GLY43 | |
| A | SER50 | |
| A | LYS193 | |
| A | PHE200 | |
| A | THR219 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG197 | |
| R | LEU109-VAL129 | |
| R | TRP206-SER232 | |
| R | GLY283-SER317 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| R | ILE56-PHE76 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
| Chain | Residue | Details |
| R | ALA77-ASN87 | |
| R | HIS151-THR184 | |
| R | SER254-LEU261 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963, ECO:0007744|PDB:8VY7, ECO:0007744|PDB:8VY9, ECO:0007744|PDB:8XQL, ECO:0007744|PDB:8XQN, ECO:0007744|PDB:8XQO, ECO:0007744|PDB:8XQP, ECO:0007744|PDB:8XQR, ECO:0007744|PDB:8XQS, ECO:0007744|PDB:8XQT, ECO:0007744|PDB:8YKY |
| Chain | Residue | Details |
| R | ILE88-PHE108 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963, ECO:0007744|PDB:8VY7, ECO:0007744|PDB:8VY9, ECO:0007744|PDB:8XQL, ECO:0007744|PDB:8XQN, ECO:0007744|PDB:8XQO, ECO:0007744|PDB:8XQP, ECO:0007744|PDB:8XQR, ECO:0007744|PDB:8XQS, ECO:0007744|PDB:8XQT, ECO:0007744|PDB:8YKY |
| Chain | Residue | Details |
| R | VAL130-ILE150 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963, ECO:0007744|PDB:8VY7, ECO:0007744|PDB:8VY9, ECO:0007744|PDB:8XQL, ECO:0007744|PDB:8XQN, ECO:0007744|PDB:8XQO, ECO:0007744|PDB:8XQP, ECO:0007744|PDB:8XQR, ECO:0007744|PDB:8XQS, ECO:0007744|PDB:8XQT, ECO:0007744|PDB:8YKY |
| Chain | Residue | Details |
| R | VAL185-MET205 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963, ECO:0007744|PDB:8VY7, ECO:0007744|PDB:8VY9, ECO:0007744|PDB:8XQL, ECO:0007744|PDB:8XQN, ECO:0007744|PDB:8XQO, ECO:0007744|PDB:8XQP, ECO:0007744|PDB:8XQR, ECO:0007744|PDB:8XQS, ECO:0007744|PDB:8XQT, ECO:0007744|PDB:8YKY |
| Chain | Residue | Details |
| R | VAL233-THR253 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963, ECO:0007744|PDB:8VY7, ECO:0007744|PDB:8VY9, ECO:0007744|PDB:8XQL, ECO:0007744|PDB:8XQN, ECO:0007744|PDB:8XQO, ECO:0007744|PDB:8XQP, ECO:0007744|PDB:8XQR, ECO:0007744|PDB:8XQS, ECO:0007744|PDB:8XQT, ECO:0007744|PDB:8YKY |
| Chain | Residue | Details |
| R | ILE262-LEU282 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963, ECO:0007744|PDB:8VY7, ECO:0007744|PDB:8VY9, ECO:0007744|PDB:8XQL, ECO:0007744|PDB:8XQN, ECO:0007744|PDB:8XQO, ECO:0007744|PDB:8XQP, ECO:0007744|PDB:8XQR, ECO:0007744|PDB:8XQS, ECO:0007744|PDB:8XQT, ECO:0007744|PDB:8YKY |
| Chain | Residue | Details |
| R | THR86 | |
| R | TRP89 | |
| R | VAL180 | |
| R | SER265 | |
| R | MET268 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| R | ASN153 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| R | ASN162 | |
| R | ASN171 |
