8XOQ

Human Calcium and Integrin Binding Protein 2 (CIB2) Fusion to TMC1 CBD-1 domain at 2.4 Angstroms resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0001750	cellular_component	photoreceptor outer segment
A	0001917	cellular_component	photoreceptor inner segment
A	0005178	molecular_function	integrin binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005927	cellular_component	muscle tendon junction
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0031594	cellular_component	neuromuscular junction
A	0032420	cellular_component	stereocilium
A	0032437	cellular_component	cuticular plate
A	0042383	cellular_component	sarcolemma
A	0042803	molecular_function	protein homodimerization activity
A	0044877	molecular_function	protein-containing complex binding
A	0045494	biological_process	photoreceptor cell maintenance
A	0046872	molecular_function	metal ion binding
A	0055074	biological_process	calcium ion homeostasis
A	0071318	biological_process	cellular response to ATP
A	0071944	cellular_component	cell periphery
A	0072562	cellular_component	blood microparticle
B	0000287	molecular_function	magnesium ion binding
B	0001750	cellular_component	photoreceptor outer segment
B	0001917	cellular_component	photoreceptor inner segment
B	0005178	molecular_function	integrin binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005927	cellular_component	muscle tendon junction
B	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
B	0031594	cellular_component	neuromuscular junction
B	0032420	cellular_component	stereocilium
B	0032437	cellular_component	cuticular plate
B	0042383	cellular_component	sarcolemma
B	0042803	molecular_function	protein homodimerization activity
B	0044877	molecular_function	protein-containing complex binding
B	0045494	biological_process	photoreceptor cell maintenance
B	0046872	molecular_function	metal ion binding
B	0055074	biological_process	calcium ion homeostasis
B	0071318	biological_process	cellular response to ATP
B	0071944	cellular_component	cell periphery
B	0072562	cellular_component	blood microparticle

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DFNTDNFICkeDL

Chain	Residue	Details
A	ASP175-LEU187
A	ASP216-PHE228

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	70
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	70
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30138589","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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