8XO1

Human KCNQ2-CaM in complex with QO-83

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001508	biological_process	action potential
A	0005216	molecular_function	monoatomic ion channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005267	molecular_function	potassium channel activity
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0007268	biological_process	chemical synaptic transmission
A	0007399	biological_process	nervous system development
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0016020	cellular_component	membrane
A	0022843	molecular_function	voltage-gated monoatomic cation channel activity
A	0030506	molecular_function	ankyrin binding
A	0033268	cellular_component	node of Ranvier
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0043194	cellular_component	axon initial segment
A	0045202	cellular_component	synapse
A	0055085	biological_process	transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
B	0001508	biological_process	action potential
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0005267	molecular_function	potassium channel activity
B	0005515	molecular_function	protein binding
B	0005516	molecular_function	calmodulin binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0007268	biological_process	chemical synaptic transmission
B	0007399	biological_process	nervous system development
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0016020	cellular_component	membrane
B	0022843	molecular_function	voltage-gated monoatomic cation channel activity
B	0030506	molecular_function	ankyrin binding
B	0033268	cellular_component	node of Ranvier
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034702	cellular_component	monoatomic ion channel complex
B	0043194	cellular_component	axon initial segment
B	0045202	cellular_component	synapse
B	0055085	biological_process	transmembrane transport
B	0071805	biological_process	potassium ion transmembrane transport
C	0000086	biological_process	G2/M transition of mitotic cell cycle
C	0000922	cellular_component	spindle pole
C	0002027	biological_process	regulation of heart rate
C	0005246	molecular_function	calcium channel regulator activity
C	0005509	molecular_function	calcium ion binding
C	0005513	biological_process	detection of calcium ion
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005876	cellular_component	spindle microtubule
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0010856	molecular_function	adenylate cyclase activator activity
C	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C	0016020	cellular_component	membrane
C	0016240	biological_process	autophagosome membrane docking
C	0019855	molecular_function	calcium channel inhibitor activity
C	0019901	molecular_function	protein kinase binding
C	0021762	biological_process	substantia nigra development
C	0030017	cellular_component	sarcomere
C	0030672	cellular_component	synaptic vesicle membrane
C	0031432	molecular_function	titin binding
C	0031514	cellular_component	motile cilium
C	0031982	cellular_component	vesicle
C	0032465	biological_process	regulation of cytokinesis
C	0032991	cellular_component	protein-containing complex
C	0034704	cellular_component	calcium channel complex
C	0035458	biological_process	cellular response to interferon-beta
C	0042995	cellular_component	cell projection
C	0043209	cellular_component	myelin sheath
C	0043539	molecular_function	protein serine/threonine kinase activator activity
C	0044305	cellular_component	calyx of Held
C	0044325	molecular_function	transmembrane transporter binding
C	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
C	0046872	molecular_function	metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0050848	biological_process	regulation of calcium-mediated signaling
C	0051592	biological_process	response to calcium ion
C	0055117	biological_process	regulation of cardiac muscle contraction
C	0060291	biological_process	long-term synaptic potentiation
C	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
C	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
C	0071346	biological_process	cellular response to type II interferon
C	0072542	molecular_function	protein phosphatase activator activity
C	0097225	cellular_component	sperm midpiece
C	0097720	biological_process	calcineurin-mediated signaling
C	0098901	biological_process	regulation of cardiac muscle cell action potential
C	0099523	cellular_component	presynaptic cytosol
C	0140056	biological_process	organelle localization by membrane tethering
C	0140238	biological_process	presynaptic endocytosis
C	0141110	molecular_function	transporter inhibitor activity
C	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
C	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
C	1902494	cellular_component	catalytic complex
C	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
C	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
D	0001508	biological_process	action potential
D	0005216	molecular_function	monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0005267	molecular_function	potassium channel activity
D	0005515	molecular_function	protein binding
D	0005516	molecular_function	calmodulin binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0007268	biological_process	chemical synaptic transmission
D	0007399	biological_process	nervous system development
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0016020	cellular_component	membrane
D	0022843	molecular_function	voltage-gated monoatomic cation channel activity
D	0030506	molecular_function	ankyrin binding
D	0033268	cellular_component	node of Ranvier
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034702	cellular_component	monoatomic ion channel complex
D	0043194	cellular_component	axon initial segment
D	0045202	cellular_component	synapse
D	0055085	biological_process	transmembrane transport
D	0071805	biological_process	potassium ion transmembrane transport
E	0000086	biological_process	G2/M transition of mitotic cell cycle
E	0000922	cellular_component	spindle pole
E	0002027	biological_process	regulation of heart rate
E	0005246	molecular_function	calcium channel regulator activity
E	0005509	molecular_function	calcium ion binding
E	0005513	biological_process	detection of calcium ion
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005876	cellular_component	spindle microtubule
E	0005886	cellular_component	plasma membrane
E	0005929	cellular_component	cilium
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0010856	molecular_function	adenylate cyclase activator activity
E	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E	0016020	cellular_component	membrane
E	0016240	biological_process	autophagosome membrane docking
E	0019855	molecular_function	calcium channel inhibitor activity
E	0019901	molecular_function	protein kinase binding
E	0021762	biological_process	substantia nigra development
E	0030017	cellular_component	sarcomere
E	0030672	cellular_component	synaptic vesicle membrane
E	0031432	molecular_function	titin binding
E	0031514	cellular_component	motile cilium
E	0031982	cellular_component	vesicle
E	0032465	biological_process	regulation of cytokinesis
E	0032991	cellular_component	protein-containing complex
E	0034704	cellular_component	calcium channel complex
E	0035458	biological_process	cellular response to interferon-beta
E	0042995	cellular_component	cell projection
E	0043209	cellular_component	myelin sheath
E	0043539	molecular_function	protein serine/threonine kinase activator activity
E	0044305	cellular_component	calyx of Held
E	0044325	molecular_function	transmembrane transporter binding
E	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
E	0046872	molecular_function	metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0050848	biological_process	regulation of calcium-mediated signaling
E	0051592	biological_process	response to calcium ion
E	0055117	biological_process	regulation of cardiac muscle contraction
E	0060291	biological_process	long-term synaptic potentiation
E	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
E	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
E	0071346	biological_process	cellular response to type II interferon
E	0072542	molecular_function	protein phosphatase activator activity
E	0097225	cellular_component	sperm midpiece
E	0097720	biological_process	calcineurin-mediated signaling
E	0098901	biological_process	regulation of cardiac muscle cell action potential
E	0099523	cellular_component	presynaptic cytosol
E	0140056	biological_process	organelle localization by membrane tethering
E	0140238	biological_process	presynaptic endocytosis
E	0141110	molecular_function	transporter inhibitor activity
E	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
E	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
E	1902494	cellular_component	catalytic complex
E	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
E	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
F	0001508	biological_process	action potential
F	0005216	molecular_function	monoatomic ion channel activity
F	0005249	molecular_function	voltage-gated potassium channel activity
F	0005267	molecular_function	potassium channel activity
F	0005515	molecular_function	protein binding
F	0005516	molecular_function	calmodulin binding
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0006813	biological_process	potassium ion transport
F	0007268	biological_process	chemical synaptic transmission
F	0007399	biological_process	nervous system development
F	0008076	cellular_component	voltage-gated potassium channel complex
F	0016020	cellular_component	membrane
F	0022843	molecular_function	voltage-gated monoatomic cation channel activity
F	0030506	molecular_function	ankyrin binding
F	0033268	cellular_component	node of Ranvier
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0034702	cellular_component	monoatomic ion channel complex
F	0043194	cellular_component	axon initial segment
F	0045202	cellular_component	synapse
F	0055085	biological_process	transmembrane transport
F	0071805	biological_process	potassium ion transmembrane transport
G	0000086	biological_process	G2/M transition of mitotic cell cycle
G	0000922	cellular_component	spindle pole
G	0002027	biological_process	regulation of heart rate
G	0005246	molecular_function	calcium channel regulator activity
G	0005509	molecular_function	calcium ion binding
G	0005513	biological_process	detection of calcium ion
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005819	cellular_component	spindle
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005876	cellular_component	spindle microtubule
G	0005886	cellular_component	plasma membrane
G	0005929	cellular_component	cilium
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0010856	molecular_function	adenylate cyclase activator activity
G	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G	0016020	cellular_component	membrane
G	0016240	biological_process	autophagosome membrane docking
G	0019855	molecular_function	calcium channel inhibitor activity
G	0019901	molecular_function	protein kinase binding
G	0021762	biological_process	substantia nigra development
G	0030017	cellular_component	sarcomere
G	0030672	cellular_component	synaptic vesicle membrane
G	0031432	molecular_function	titin binding
G	0031514	cellular_component	motile cilium
G	0031982	cellular_component	vesicle
G	0032465	biological_process	regulation of cytokinesis
G	0032991	cellular_component	protein-containing complex
G	0034704	cellular_component	calcium channel complex
G	0035458	biological_process	cellular response to interferon-beta
G	0042995	cellular_component	cell projection
G	0043209	cellular_component	myelin sheath
G	0043539	molecular_function	protein serine/threonine kinase activator activity
G	0044305	cellular_component	calyx of Held
G	0044325	molecular_function	transmembrane transporter binding
G	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
G	0046872	molecular_function	metal ion binding
G	0048306	molecular_function	calcium-dependent protein binding
G	0050848	biological_process	regulation of calcium-mediated signaling
G	0051592	biological_process	response to calcium ion
G	0055117	biological_process	regulation of cardiac muscle contraction
G	0060291	biological_process	long-term synaptic potentiation
G	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
G	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
G	0071346	biological_process	cellular response to type II interferon
G	0072542	molecular_function	protein phosphatase activator activity
G	0097225	cellular_component	sperm midpiece
G	0097720	biological_process	calcineurin-mediated signaling
G	0098901	biological_process	regulation of cardiac muscle cell action potential
G	0099523	cellular_component	presynaptic cytosol
G	0140056	biological_process	organelle localization by membrane tethering
G	0140238	biological_process	presynaptic endocytosis
G	0141110	molecular_function	transporter inhibitor activity
G	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
G	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
G	1902494	cellular_component	catalytic complex
G	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
G	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
H	0000086	biological_process	G2/M transition of mitotic cell cycle
H	0000922	cellular_component	spindle pole
H	0002027	biological_process	regulation of heart rate
H	0005246	molecular_function	calcium channel regulator activity
H	0005509	molecular_function	calcium ion binding
H	0005513	biological_process	detection of calcium ion
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005819	cellular_component	spindle
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005876	cellular_component	spindle microtubule
H	0005886	cellular_component	plasma membrane
H	0005929	cellular_component	cilium
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
H	0008076	cellular_component	voltage-gated potassium channel complex
H	0010856	molecular_function	adenylate cyclase activator activity
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0016240	biological_process	autophagosome membrane docking
H	0019855	molecular_function	calcium channel inhibitor activity
H	0019901	molecular_function	protein kinase binding
H	0021762	biological_process	substantia nigra development
H	0030017	cellular_component	sarcomere
H	0030672	cellular_component	synaptic vesicle membrane
H	0031432	molecular_function	titin binding
H	0031514	cellular_component	motile cilium
H	0031982	cellular_component	vesicle
H	0032465	biological_process	regulation of cytokinesis
H	0032991	cellular_component	protein-containing complex
H	0034704	cellular_component	calcium channel complex
H	0035458	biological_process	cellular response to interferon-beta
H	0042995	cellular_component	cell projection
H	0043209	cellular_component	myelin sheath
H	0043539	molecular_function	protein serine/threonine kinase activator activity
H	0044305	cellular_component	calyx of Held
H	0044325	molecular_function	transmembrane transporter binding
H	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
H	0046872	molecular_function	metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0050848	biological_process	regulation of calcium-mediated signaling
H	0051592	biological_process	response to calcium ion
H	0055117	biological_process	regulation of cardiac muscle contraction
H	0060291	biological_process	long-term synaptic potentiation
H	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
H	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
H	0071346	biological_process	cellular response to type II interferon
H	0072542	molecular_function	protein phosphatase activator activity
H	0097225	cellular_component	sperm midpiece
H	0097720	biological_process	calcineurin-mediated signaling
H	0098901	biological_process	regulation of cardiac muscle cell action potential
H	0099523	cellular_component	presynaptic cytosol
H	0140056	biological_process	organelle localization by membrane tethering
H	0140238	biological_process	presynaptic endocytosis
H	0141110	molecular_function	transporter inhibitor activity
H	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
H	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
H	1902494	cellular_component	catalytic complex
H	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
H	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
H	ASP21-LEU33
H	ASP57-PHE69
H	ASP94-LEU106
H	ASP130-PHE142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03

Chain	Residue	Details
H	ASP21
H	GLU68
C	ASP21
C	ASP23
C	ASP25
C	THR27
C	GLU32
C	ASP57
C	ASP59
C	ASN61
C	THR63
H	ASP23
C	GLU68
E	ASP21
E	ASP23
E	ASP25
E	THR27
E	GLU32
E	ASP57
E	ASP59
E	ASN61
E	THR63
H	ASP25
E	GLU68
G	ASP21
G	ASP23
G	ASP25
G	THR27
G	GLU32
G	ASP57
G	ASP59
G	ASN61
G	THR63
H	THR27
G	GLU68
H	GLU32
H	ASP57
H	ASP59
H	ASN61
H	THR63

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0000269|PubMed:29724949, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03, ECO:0007744|PDB:6CNN, ECO:0007744|PDB:6CNO

Chain	Residue	Details
H	ASP94
C	GLU105
E	ASP94
E	ASP96
E	ASN98
E	TYR100
E	GLU105
G	ASP94
G	ASP96
G	ASN98
G	TYR100
H	ASP96
G	GLU105
H	ASN98
H	TYR100
H	GLU105
C	ASP94
C	ASP96
C	ASN98
C	TYR100

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03

Chain	Residue	Details
H	ASP130
C	GLU141
E	ASP130
E	ASP132
E	ASP134
E	GLN136
E	GLU141
G	ASP130
G	ASP132
G	ASP134
G	GLN136
H	ASP132
G	GLU141
H	ASP134
H	GLN136
H	GLU141
C	ASP130
C	ASP132
C	ASP134
C	GLN136

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
H	ALA2
C	ALA2
E	ALA2
G	ALA2

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
H	LYS22
C	LYS22
E	LYS22
G	LYS22

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29

Chain	Residue	Details
H	THR45
C	THR45
E	THR45
G	THR45

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
H	SER82
C	SER82
E	SER82
G	SER82

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
H	LYS95
C	LYS95
E	LYS95
G	LYS95

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
H	TYR100
C	TYR100
E	TYR100
G	TYR100

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
H	SER102
C	SER102
E	SER102
G	SER102
D	ARG214
D	LYS327
F	ARG214
F	LYS327

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
H	THR111
C	THR111
E	THR111
G	THR111

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315

Chain	Residue	Details
H	LYS116
C	LYS116
E	LYS116
G	LYS116

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
H	TYR139
C	TYR139
E	TYR139
G	TYR139

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157

Chain	Residue	Details
H	LYS22
B	SER478
D	SER466
D	SER468
D	SER472
D	SER476
D	SER478
F	SER466
F	SER468
F	SER472
F	SER476
A	SER468
F	SER478
C	LYS22
A	SER476
E	LYS22
B	SER466
G	LYS22
B	SER472
B	SER476

---

site_id	SWS_FT_FI15
Number of Residues	16
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O88943

Chain	Residue	Details
A	SER507
D	SER672
D	SER801
D	SER803
F	SER507
F	SER672
F	SER801
F	SER803
A	SER672
A	SER801
A	SER803
B	SER507
B	SER672
B	SER801
B	SER803
D	SER507

---