8XKF

Crystal structure of Helicobacter pylori IspDF with substrate CTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0008299	biological_process	isoprenoid biosynthetic process
A	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A	0016114	biological_process	terpenoid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016829	molecular_function	lyase activity
A	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
A	0046872	molecular_function	metal ion binding
A	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A	0070567	molecular_function	cytidylyltransferase activity
B	0003824	molecular_function	catalytic activity
B	0008299	biological_process	isoprenoid biosynthetic process
B	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B	0016114	biological_process	terpenoid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0016829	molecular_function	lyase activity
B	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
B	0046872	molecular_function	metal ion binding
B	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B	0070567	molecular_function	cytidylyltransferase activity
C	0003824	molecular_function	catalytic activity
C	0008299	biological_process	isoprenoid biosynthetic process
C	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C	0016114	biological_process	terpenoid biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0016829	molecular_function	lyase activity
C	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
C	0046872	molecular_function	metal ion binding
C	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C	0070567	molecular_function	cytidylyltransferase activity
D	0003824	molecular_function	catalytic activity
D	0008299	biological_process	isoprenoid biosynthetic process
D	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D	0016114	biological_process	terpenoid biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0016829	molecular_function	lyase activity
D	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
D	0046872	molecular_function	metal ion binding
D	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D	0070567	molecular_function	cytidylyltransferase activity
E	0003824	molecular_function	catalytic activity
E	0008299	biological_process	isoprenoid biosynthetic process
E	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E	0016114	biological_process	terpenoid biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0016829	molecular_function	lyase activity
E	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
E	0046872	molecular_function	metal ion binding
E	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E	0070567	molecular_function	cytidylyltransferase activity
F	0003824	molecular_function	catalytic activity
F	0008299	biological_process	isoprenoid biosynthetic process
F	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F	0016114	biological_process	terpenoid biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016779	molecular_function	nucleotidyltransferase activity
F	0016829	molecular_function	lyase activity
F	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
F	0046872	molecular_function	metal ion binding
F	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F	0070567	molecular_function	cytidylyltransferase activity

Functional Information from PROSITE/UniProt

site_id	PS01295
Number of Residues	8
Details	ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. TLTSDVAR

Chain	Residue	Details
A	THR126-ARG133

---

site_id	PS01350
Number of Residues	16
Details	ISPF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. SDGDALlHAviDAilG

Chain	Residue	Details
A	SER281-GLY296

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	102
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01520","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"HAMAP-Rule","id":"MF_01520","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Site: {"description":"Positions MEP for the nucleophilic attack","evidences":[{"source":"HAMAP-Rule","id":"MF_01520","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	474
Details	Region: {"description":"2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase","evidences":[{"source":"HAMAP-Rule","id":"MF_01520","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---