8XJ4
Structure of prostatic acid phosphatase in human semen
Functional Information from PROSITE/UniProt
| site_id | PS00616 |
| Number of Residues | 15 |
| Details | HIS_ACID_PHOSPHAT_1 Histidine acid phosphatases phosphohistidine signature. LkfVtlVfRHGdRsP |
| Chain | Residue | Details |
| B | LEU35-PRO49 |
| site_id | PS00778 |
| Number of Residues | 17 |
| Details | HIS_ACID_PHOSPHAT_2 Histidine acid phosphatases active site signature. LiMYsAHDTTVsgLqmA |
| Chain | Residue | Details |
| B | LEU283-ALA299 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:1989985 |
| Chain | Residue | Details |
| B | HIS44 | |
| A | HIS44 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:1989985 |
| Chain | Residue | Details |
| B | ASP290 | |
| A | ASP290 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9804805 |
| Chain | Residue | Details |
| B | ARG43 | |
| B | ARG47 | |
| B | ARG111 | |
| B | HIS289 | |
| A | ARG43 | |
| A | ARG47 | |
| A | ARG111 | |
| A | HIS289 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Important for substrate specificity |
| Chain | Residue | Details |
| B | PRO49 | |
| A | PRO49 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | SITE: Required for homodimerization => ECO:0000250|UniProtKB:P20646 |
| Chain | Residue | Details |
| B | TRP138 | |
| B | HIS144 | |
| A | TRP138 | |
| A | HIS144 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Required for structural stability => ECO:0000269|PubMed:9584846 |
| Chain | Residue | Details |
| B | TRP206 | |
| A | TRP206 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10639192 |
| Chain | Residue | Details |
| B | ASN94 | |
| A | ASN94 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10639192, ECO:0000269|PubMed:12525165 |
| Chain | Residue | Details |
| B | ASN220 | |
| A | ASN220 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12525165 |
| Chain | Residue | Details |
| B | ASN333 | |
| A | ASN333 |
