8XI2

Cryo-EM structure of the Chlamydomonas C* complex

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000243	cellular_component	commitment complex
a	0000387	biological_process	spliceosomal snRNP assembly
a	0003723	molecular_function	RNA binding
a	0005634	cellular_component	nucleus
a	0005681	cellular_component	spliceosomal complex
a	0005682	cellular_component	U5 snRNP
a	0005685	cellular_component	U1 snRNP
a	0005686	cellular_component	U2 snRNP
a	0005687	cellular_component	U4 snRNP
a	0005829	cellular_component	cytosol
a	0006396	biological_process	RNA processing
a	0006397	biological_process	mRNA processing
a	0008380	biological_process	RNA splicing
a	0034719	cellular_component	SMN-Sm protein complex
a	0071011	cellular_component	precatalytic spliceosome
a	0071013	cellular_component	catalytic step 2 spliceosome
a	0097526	cellular_component	spliceosomal tri-snRNP complex
a	1990904	cellular_component	ribonucleoprotein complex
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000393	biological_process	spliceosomal conformational changes to generate catalytic conformation
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0000974	cellular_component	Prp19 complex
A	0003723	molecular_function	RNA binding
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0017070	molecular_function	U6 snRNA binding
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0045292	biological_process	mRNA cis splicing, via spliceosome
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0097157	molecular_function	pre-mRNA intronic binding
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003723	molecular_function	RNA binding
b	0005634	cellular_component	nucleus
b	0005682	cellular_component	U5 snRNP
b	0005685	cellular_component	U1 snRNP
b	0005686	cellular_component	U2 snRNP
b	0005687	cellular_component	U4 snRNP
b	0005737	cellular_component	cytoplasm
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0070990	molecular_function	snRNP binding
b	0071004	cellular_component	U2-type prespliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	1990904	cellular_component	ribonucleoprotein complex
c	0000243	cellular_component	commitment complex
c	0000387	biological_process	spliceosomal snRNP assembly
c	0003723	molecular_function	RNA binding
c	0005634	cellular_component	nucleus
c	0005682	cellular_component	U5 snRNP
c	0005685	cellular_component	U1 snRNP
c	0005686	cellular_component	U2 snRNP
c	0005687	cellular_component	U4 snRNP
c	0006396	biological_process	RNA processing
c	0006397	biological_process	mRNA processing
c	0008380	biological_process	RNA splicing
c	0031981	cellular_component	nuclear lumen
c	0034715	cellular_component	pICln-Sm protein complex
c	0034719	cellular_component	SMN-Sm protein complex
c	0035194	biological_process	regulatory ncRNA-mediated post-transcriptional gene silencing
c	0071011	cellular_component	precatalytic spliceosome
c	0071013	cellular_component	catalytic step 2 spliceosome
c	0097526	cellular_component	spliceosomal tri-snRNP complex
c	1990904	cellular_component	ribonucleoprotein complex
C	0000166	molecular_function	nucleotide binding
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0030623	molecular_function	U5 snRNA binding
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0046872	molecular_function	metal ion binding
C	0071007	cellular_component	U2-type catalytic step 2 spliceosome
d	0000387	biological_process	spliceosomal snRNP assembly
d	0000398	biological_process	mRNA splicing, via spliceosome
d	0003723	molecular_function	RNA binding
d	0005634	cellular_component	nucleus
d	0005681	cellular_component	spliceosomal complex
d	0005682	cellular_component	U5 snRNP
d	0005685	cellular_component	U1 snRNP
d	0005686	cellular_component	U2 snRNP
d	0005689	cellular_component	U12-type spliceosomal complex
d	0005829	cellular_component	cytosol
d	0006397	biological_process	mRNA processing
d	0008380	biological_process	RNA splicing
d	0030532	cellular_component	small nuclear ribonucleoprotein complex
d	0034715	cellular_component	pICln-Sm protein complex
d	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
d	0071011	cellular_component	precatalytic spliceosome
d	0071013	cellular_component	catalytic step 2 spliceosome
d	1990904	cellular_component	ribonucleoprotein complex
e	0000387	biological_process	spliceosomal snRNP assembly
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0003723	molecular_function	RNA binding
e	0005634	cellular_component	nucleus
e	0005681	cellular_component	spliceosomal complex
e	0005682	cellular_component	U5 snRNP
e	0005685	cellular_component	U1 snRNP
e	0005686	cellular_component	U2 snRNP
e	0005687	cellular_component	U4 snRNP
e	0005829	cellular_component	cytosol
e	0006397	biological_process	mRNA processing
e	0008380	biological_process	RNA splicing
e	0034715	cellular_component	pICln-Sm protein complex
e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
e	0071011	cellular_component	precatalytic spliceosome
e	1990904	cellular_component	ribonucleoprotein complex
E	0000375	biological_process	RNA splicing, via transesterification reactions
E	0005634	cellular_component	nucleus
E	0005681	cellular_component	spliceosomal complex
E	0005682	cellular_component	U5 snRNP
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0071013	cellular_component	catalytic step 2 spliceosome
f	0000398	biological_process	mRNA splicing, via spliceosome
f	0003723	molecular_function	RNA binding
f	0005634	cellular_component	nucleus
f	0005681	cellular_component	spliceosomal complex
f	0005685	cellular_component	U1 snRNP
f	0006397	biological_process	mRNA processing
f	0008380	biological_process	RNA splicing
f	0034715	cellular_component	pICln-Sm protein complex
f	0071013	cellular_component	catalytic step 2 spliceosome
f	0120114	cellular_component	Sm-like protein family complex
f	1990904	cellular_component	ribonucleoprotein complex
g	0000387	biological_process	spliceosomal snRNP assembly
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0003723	molecular_function	RNA binding
g	0005634	cellular_component	nucleus
g	0005681	cellular_component	spliceosomal complex
g	0005682	cellular_component	U5 snRNP
g	0005685	cellular_component	U1 snRNP
g	0005686	cellular_component	U2 snRNP
g	0005687	cellular_component	U4 snRNP
g	0005689	cellular_component	U12-type spliceosomal complex
g	0006397	biological_process	mRNA processing
g	0008380	biological_process	RNA splicing
g	0034719	cellular_component	SMN-Sm protein complex
g	0043186	cellular_component	P granule
g	0071004	cellular_component	U2-type prespliceosome
g	0071011	cellular_component	precatalytic spliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	0097526	cellular_component	spliceosomal tri-snRNP complex
g	1990904	cellular_component	ribonucleoprotein complex
I	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0000974	cellular_component	Prp19 complex
I	0005634	cellular_component	nucleus
I	0005681	cellular_component	spliceosomal complex
I	0006396	biological_process	RNA processing
I	0006397	biological_process	mRNA processing
I	0008380	biological_process	RNA splicing
I	0071007	cellular_component	U2-type catalytic step 2 spliceosome
I	0071014	cellular_component	post-mRNA release spliceosomal complex
J	0000245	biological_process	spliceosomal complex assembly
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0000974	cellular_component	Prp19 complex
J	0005634	cellular_component	nucleus
J	0005681	cellular_component	spliceosomal complex
J	0006396	biological_process	RNA processing
J	0006397	biological_process	mRNA processing
J	0008380	biological_process	RNA splicing
J	0071007	cellular_component	U2-type catalytic step 2 spliceosome
J	0071014	cellular_component	post-mRNA release spliceosomal complex
K	0000974	cellular_component	Prp19 complex
K	0005634	cellular_component	nucleus
K	0005681	cellular_component	spliceosomal complex
K	0006397	biological_process	mRNA processing
K	0008380	biological_process	RNA splicing
K	0071013	cellular_component	catalytic step 2 spliceosome
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0000974	cellular_component	Prp19 complex
L	0003677	molecular_function	DNA binding
L	0005681	cellular_component	spliceosomal complex
L	0006281	biological_process	DNA repair
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006397	biological_process	mRNA processing
L	0006974	biological_process	DNA damage response
L	0008380	biological_process	RNA splicing
M	0000413	biological_process	protein peptidyl-prolyl isomerization
M	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
M	0005634	cellular_component	nucleus
M	0005681	cellular_component	spliceosomal complex
M	0005737	cellular_component	cytoplasm
M	0006397	biological_process	mRNA processing
M	0006457	biological_process	protein folding
M	0008380	biological_process	RNA splicing
M	0016018	molecular_function	cyclosporin A binding
M	0016853	molecular_function	isomerase activity
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0005634	cellular_component	nucleus
N	0005681	cellular_component	spliceosomal complex
N	0046872	molecular_function	metal ion binding
O	0000974	cellular_component	Prp19 complex
O	0003676	molecular_function	nucleic acid binding
O	0003723	molecular_function	RNA binding
O	0005634	cellular_component	nucleus
O	0005681	cellular_component	spliceosomal complex
O	0006397	biological_process	mRNA processing
O	0008270	molecular_function	zinc ion binding
O	0008380	biological_process	RNA splicing
O	0017070	molecular_function	U6 snRNA binding
O	0036002	molecular_function	pre-mRNA binding
O	0046872	molecular_function	metal ion binding
O	0071006	cellular_component	U2-type catalytic step 1 spliceosome
O	0071007	cellular_component	U2-type catalytic step 2 spliceosome
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0003723	molecular_function	RNA binding
P	0005681	cellular_component	spliceosomal complex
P	0006397	biological_process	mRNA processing
P	0008380	biological_process	RNA splicing
P	0045292	biological_process	mRNA cis splicing, via spliceosome
P	0071013	cellular_component	catalytic step 2 spliceosome
q	0000398	biological_process	mRNA splicing, via spliceosome
q	0000974	cellular_component	Prp19 complex
q	0004842	molecular_function	ubiquitin-protein transferase activity
q	0005634	cellular_component	nucleus
q	0005681	cellular_component	spliceosomal complex
q	0005737	cellular_component	cytoplasm
q	0006281	biological_process	DNA repair
q	0006397	biological_process	mRNA processing
q	0006974	biological_process	DNA damage response
q	0008380	biological_process	RNA splicing
q	0016567	biological_process	protein ubiquitination
q	0016740	molecular_function	transferase activity
q	0061630	molecular_function	ubiquitin protein ligase activity
q	0070534	biological_process	protein K63-linked ubiquitination
q	0071006	cellular_component	U2-type catalytic step 1 spliceosome
Q	0003729	molecular_function	mRNA binding
Q	0004386	molecular_function	helicase activity
Q	0071013	cellular_component	catalytic step 2 spliceosome
r	0000398	biological_process	mRNA splicing, via spliceosome
r	0000974	cellular_component	Prp19 complex
r	0004842	molecular_function	ubiquitin-protein transferase activity
r	0005634	cellular_component	nucleus
r	0005681	cellular_component	spliceosomal complex
r	0005737	cellular_component	cytoplasm
r	0006281	biological_process	DNA repair
r	0006397	biological_process	mRNA processing
r	0006974	biological_process	DNA damage response
r	0008380	biological_process	RNA splicing
r	0016567	biological_process	protein ubiquitination
r	0016740	molecular_function	transferase activity
r	0061630	molecular_function	ubiquitin protein ligase activity
r	0070534	biological_process	protein K63-linked ubiquitination
r	0071006	cellular_component	U2-type catalytic step 1 spliceosome
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0005681	cellular_component	spliceosomal complex
s	0000398	biological_process	mRNA splicing, via spliceosome
s	0000974	cellular_component	Prp19 complex
s	0004842	molecular_function	ubiquitin-protein transferase activity
s	0005634	cellular_component	nucleus
s	0005681	cellular_component	spliceosomal complex
s	0005737	cellular_component	cytoplasm
s	0006281	biological_process	DNA repair
s	0006397	biological_process	mRNA processing
s	0006974	biological_process	DNA damage response
s	0008380	biological_process	RNA splicing
s	0016567	biological_process	protein ubiquitination
s	0016740	molecular_function	transferase activity
s	0061630	molecular_function	ubiquitin protein ligase activity
s	0070534	biological_process	protein K63-linked ubiquitination
s	0071006	cellular_component	U2-type catalytic step 1 spliceosome
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0000413	biological_process	protein peptidyl-prolyl isomerization
S	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
S	0005634	cellular_component	nucleus
S	0006457	biological_process	protein folding
S	0016853	molecular_function	isomerase activity
S	0071013	cellular_component	catalytic step 2 spliceosome
t	0000398	biological_process	mRNA splicing, via spliceosome
t	0000974	cellular_component	Prp19 complex
t	0004842	molecular_function	ubiquitin-protein transferase activity
t	0005634	cellular_component	nucleus
t	0005681	cellular_component	spliceosomal complex
t	0005737	cellular_component	cytoplasm
t	0006281	biological_process	DNA repair
t	0006397	biological_process	mRNA processing
t	0006974	biological_process	DNA damage response
t	0008380	biological_process	RNA splicing
t	0016567	biological_process	protein ubiquitination
t	0016740	molecular_function	transferase activity
t	0061630	molecular_function	ubiquitin protein ligase activity
t	0070534	biological_process	protein K63-linked ubiquitination
t	0071006	cellular_component	U2-type catalytic step 1 spliceosome
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0000974	cellular_component	Prp19 complex
T	0071013	cellular_component	catalytic step 2 spliceosome
U	0005634	cellular_component	nucleus
V	0000398	biological_process	mRNA splicing, via spliceosome
V	0003723	molecular_function	RNA binding
V	0005634	cellular_component	nucleus
V	0006397	biological_process	mRNA processing
V	0008380	biological_process	RNA splicing
V	0071013	cellular_component	catalytic step 2 spliceosome
W	0000398	biological_process	mRNA splicing, via spliceosome
W	0003729	molecular_function	mRNA binding
W	0005634	cellular_component	nucleus
W	0005681	cellular_component	spliceosomal complex
W	0006397	biological_process	mRNA processing
W	0008380	biological_process	RNA splicing
W	0071013	cellular_component	catalytic step 2 spliceosome

Functional Information from PROSITE/UniProt

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YdgTiFHRIIrdFMcQGG

Chain	Residue	Details
S	TYR40-GLY57
M	PHE55-GLY72

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site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LMTGgrDsVVRVWDM

Chain	Residue	Details
T	LEU306-MET320
T	VAL348-LEU362
E	VAL207-LEU221
W	LEU299-VAL313

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