8XH9

Human Cx36/GJD2 (Ala14 deletion mutant) gap junction channel prepared with mefloquine, showing no bound mefloquine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005243	molecular_function	gap junction channel activity
A	0005886	cellular_component	plasma membrane
A	0005921	cellular_component	gap junction
A	0005922	cellular_component	connexin complex
A	0007154	biological_process	cell communication
A	0007267	biological_process	cell-cell signaling
A	0007268	biological_process	chemical synaptic transmission
A	0007601	biological_process	visual perception
A	0016020	cellular_component	membrane
A	0019228	biological_process	neuronal action potential
A	0045202	cellular_component	synapse
A	0055085	biological_process	transmembrane transport
A	0070161	cellular_component	anchoring junction
B	0005243	molecular_function	gap junction channel activity
B	0005886	cellular_component	plasma membrane
B	0005921	cellular_component	gap junction
B	0005922	cellular_component	connexin complex
B	0007154	biological_process	cell communication
B	0007267	biological_process	cell-cell signaling
B	0007268	biological_process	chemical synaptic transmission
B	0007601	biological_process	visual perception
B	0016020	cellular_component	membrane
B	0019228	biological_process	neuronal action potential
B	0045202	cellular_component	synapse
B	0055085	biological_process	transmembrane transport
B	0070161	cellular_component	anchoring junction
C	0005243	molecular_function	gap junction channel activity
C	0005886	cellular_component	plasma membrane
C	0005921	cellular_component	gap junction
C	0005922	cellular_component	connexin complex
C	0007154	biological_process	cell communication
C	0007267	biological_process	cell-cell signaling
C	0007268	biological_process	chemical synaptic transmission
C	0007601	biological_process	visual perception
C	0016020	cellular_component	membrane
C	0019228	biological_process	neuronal action potential
C	0045202	cellular_component	synapse
C	0055085	biological_process	transmembrane transport
C	0070161	cellular_component	anchoring junction
D	0005243	molecular_function	gap junction channel activity
D	0005886	cellular_component	plasma membrane
D	0005921	cellular_component	gap junction
D	0005922	cellular_component	connexin complex
D	0007154	biological_process	cell communication
D	0007267	biological_process	cell-cell signaling
D	0007268	biological_process	chemical synaptic transmission
D	0007601	biological_process	visual perception
D	0016020	cellular_component	membrane
D	0019228	biological_process	neuronal action potential
D	0045202	cellular_component	synapse
D	0055085	biological_process	transmembrane transport
D	0070161	cellular_component	anchoring junction
E	0005243	molecular_function	gap junction channel activity
E	0005886	cellular_component	plasma membrane
E	0005921	cellular_component	gap junction
E	0005922	cellular_component	connexin complex
E	0007154	biological_process	cell communication
E	0007267	biological_process	cell-cell signaling
E	0007268	biological_process	chemical synaptic transmission
E	0007601	biological_process	visual perception
E	0016020	cellular_component	membrane
E	0019228	biological_process	neuronal action potential
E	0045202	cellular_component	synapse
E	0055085	biological_process	transmembrane transport
E	0070161	cellular_component	anchoring junction
F	0005243	molecular_function	gap junction channel activity
F	0005886	cellular_component	plasma membrane
F	0005921	cellular_component	gap junction
F	0005922	cellular_component	connexin complex
F	0007154	biological_process	cell communication
F	0007267	biological_process	cell-cell signaling
F	0007268	biological_process	chemical synaptic transmission
F	0007601	biological_process	visual perception
F	0016020	cellular_component	membrane
F	0019228	biological_process	neuronal action potential
F	0045202	cellular_component	synapse
F	0055085	biological_process	transmembrane transport
F	0070161	cellular_component	anchoring junction
G	0005243	molecular_function	gap junction channel activity
G	0005886	cellular_component	plasma membrane
G	0005921	cellular_component	gap junction
G	0005922	cellular_component	connexin complex
G	0007154	biological_process	cell communication
G	0007267	biological_process	cell-cell signaling
G	0007268	biological_process	chemical synaptic transmission
G	0007601	biological_process	visual perception
G	0016020	cellular_component	membrane
G	0019228	biological_process	neuronal action potential
G	0045202	cellular_component	synapse
G	0055085	biological_process	transmembrane transport
G	0070161	cellular_component	anchoring junction
H	0005243	molecular_function	gap junction channel activity
H	0005886	cellular_component	plasma membrane
H	0005921	cellular_component	gap junction
H	0005922	cellular_component	connexin complex
H	0007154	biological_process	cell communication
H	0007267	biological_process	cell-cell signaling
H	0007268	biological_process	chemical synaptic transmission
H	0007601	biological_process	visual perception
H	0016020	cellular_component	membrane
H	0019228	biological_process	neuronal action potential
H	0045202	cellular_component	synapse
H	0055085	biological_process	transmembrane transport
H	0070161	cellular_component	anchoring junction
I	0005243	molecular_function	gap junction channel activity
I	0005886	cellular_component	plasma membrane
I	0005921	cellular_component	gap junction
I	0005922	cellular_component	connexin complex
I	0007154	biological_process	cell communication
I	0007267	biological_process	cell-cell signaling
I	0007268	biological_process	chemical synaptic transmission
I	0007601	biological_process	visual perception
I	0016020	cellular_component	membrane
I	0019228	biological_process	neuronal action potential
I	0045202	cellular_component	synapse
I	0055085	biological_process	transmembrane transport
I	0070161	cellular_component	anchoring junction
J	0005243	molecular_function	gap junction channel activity
J	0005886	cellular_component	plasma membrane
J	0005921	cellular_component	gap junction
J	0005922	cellular_component	connexin complex
J	0007154	biological_process	cell communication
J	0007267	biological_process	cell-cell signaling
J	0007268	biological_process	chemical synaptic transmission
J	0007601	biological_process	visual perception
J	0016020	cellular_component	membrane
J	0019228	biological_process	neuronal action potential
J	0045202	cellular_component	synapse
J	0055085	biological_process	transmembrane transport
J	0070161	cellular_component	anchoring junction
K	0005243	molecular_function	gap junction channel activity
K	0005886	cellular_component	plasma membrane
K	0005921	cellular_component	gap junction
K	0005922	cellular_component	connexin complex
K	0007154	biological_process	cell communication
K	0007267	biological_process	cell-cell signaling
K	0007268	biological_process	chemical synaptic transmission
K	0007601	biological_process	visual perception
K	0016020	cellular_component	membrane
K	0019228	biological_process	neuronal action potential
K	0045202	cellular_component	synapse
K	0055085	biological_process	transmembrane transport
K	0070161	cellular_component	anchoring junction
L	0005243	molecular_function	gap junction channel activity
L	0005886	cellular_component	plasma membrane
L	0005921	cellular_component	gap junction
L	0005922	cellular_component	connexin complex
L	0007154	biological_process	cell communication
L	0007267	biological_process	cell-cell signaling
L	0007268	biological_process	chemical synaptic transmission
L	0007601	biological_process	visual perception
L	0016020	cellular_component	membrane
L	0019228	biological_process	neuronal action potential
L	0045202	cellular_component	synapse
L	0055085	biological_process	transmembrane transport
L	0070161	cellular_component	anchoring junction

Functional Information from PROSITE/UniProt

site_id	PS00407
Number of Residues	14
Details	CONNEXINS_1 Connexins signature 1. CNTlQPGCnqACYD

Chain	Residue	Details
A	CYS55-ASP68

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site_id	PS00408
Number of Residues	17
Details	CONNEXINS_2 Connexins signature 2. Cnry.PCikeVECYVSRP

Chain	Residue	Details
A	CYS231-PRO247

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1056
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	756
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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