Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8XGT

Crystal structure of human secretory glutaminyl cyclase in complex with (Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-hydroxyindolin-2-one

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0008270	molecular_function	zinc ion binding
A	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
A	0016746	molecular_function	acyltransferase activity
A	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
A	0035580	cellular_component	specific granule lumen
A	0036211	biological_process	protein modification process
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0008270	molecular_function	zinc ion binding
B	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
B	0016746	molecular_function	acyltransferase activity
B	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
B	0035580	cellular_component	specific granule lumen
B	0036211	biological_process	protein modification process
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0008270	molecular_function	zinc ion binding
C	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
C	0016746	molecular_function	acyltransferase activity
C	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
C	0035580	cellular_component	specific granule lumen
C	0036211	biological_process	protein modification process
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	1904724	cellular_component	tertiary granule lumen
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0008270	molecular_function	zinc ion binding
D	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
D	0016746	molecular_function	acyltransferase activity
D	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
D	0035580	cellular_component	specific granule lumen
D	0036211	biological_process	protein modification process
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	1904724	cellular_component	tertiary granule lumen
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0008270	molecular_function	zinc ion binding
E	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
E	0016746	molecular_function	acyltransferase activity
E	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
E	0035580	cellular_component	specific granule lumen
E	0036211	biological_process	protein modification process
E	0046872	molecular_function	metal ion binding
E	0070062	cellular_component	extracellular exosome
E	1904724	cellular_component	tertiary granule lumen
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0008270	molecular_function	zinc ion binding
F	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
F	0016746	molecular_function	acyltransferase activity
F	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
F	0035580	cellular_component	specific granule lumen
F	0036211	biological_process	protein modification process
F	0046872	molecular_function	metal ion binding
F	0070062	cellular_component	extracellular exosome
F	1904724	cellular_component	tertiary granule lumen
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0008270	molecular_function	zinc ion binding
G	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
G	0016746	molecular_function	acyltransferase activity
G	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
G	0035580	cellular_component	specific granule lumen
G	0036211	biological_process	protein modification process
G	0046872	molecular_function	metal ion binding
G	0070062	cellular_component	extracellular exosome
G	1904724	cellular_component	tertiary granule lumen
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0008270	molecular_function	zinc ion binding
H	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
H	0016746	molecular_function	acyltransferase activity
H	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
H	0035580	cellular_component	specific granule lumen
H	0036211	biological_process	protein modification process
H	0046872	molecular_function	metal ion binding
H	0070062	cellular_component	extracellular exosome
H	1904724	cellular_component	tertiary granule lumen
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0008270	molecular_function	zinc ion binding
I	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
I	0016746	molecular_function	acyltransferase activity
I	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
I	0035580	cellular_component	specific granule lumen
I	0036211	biological_process	protein modification process
I	0046872	molecular_function	metal ion binding
I	0070062	cellular_component	extracellular exosome
I	1904724	cellular_component	tertiary granule lumen
I	1904813	cellular_component	ficolin-1-rich granule lumen
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0008270	molecular_function	zinc ion binding
J	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
J	0016746	molecular_function	acyltransferase activity
J	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
J	0035580	cellular_component	specific granule lumen
J	0036211	biological_process	protein modification process
J	0046872	molecular_function	metal ion binding
J	0070062	cellular_component	extracellular exosome
J	1904724	cellular_component	tertiary granule lumen
J	1904813	cellular_component	ficolin-1-rich granule lumen
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0008270	molecular_function	zinc ion binding
K	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
K	0016746	molecular_function	acyltransferase activity
K	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
K	0035580	cellular_component	specific granule lumen
K	0036211	biological_process	protein modification process
K	0046872	molecular_function	metal ion binding
K	0070062	cellular_component	extracellular exosome
K	1904724	cellular_component	tertiary granule lumen
K	1904813	cellular_component	ficolin-1-rich granule lumen
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0008270	molecular_function	zinc ion binding
L	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
L	0016746	molecular_function	acyltransferase activity
L	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
L	0035580	cellular_component	specific granule lumen
L	0036211	biological_process	protein modification process
L	0046872	molecular_function	metal ion binding
L	0070062	cellular_component	extracellular exosome
L	1904724	cellular_component	tertiary granule lumen
L	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	ACT_SITE: Proton acceptor => ECO:0000269\|PubMed:18072935

Chain	Residue	Details
B	GLU201
E	ASP248
F	GLU201
F	ASP248
G	GLU201
G	ASP248
H	GLU201
H	ASP248
I	GLU201
I	ASP248
J	GLU201
B	ASP248
J	ASP248
K	GLU201
K	ASP248
L	GLU201
L	ASP248
A	GLU201
A	ASP248
C	GLU201
C	ASP248
D	GLU201
D	ASP248
E	GLU201

site_id	SWS_FT_FI2
Number of Residues	36
Details	BINDING: BINDING => ECO:0000269\|PubMed:16135565, ECO:0000269\|PubMed:18072935, ECO:0000269\|PubMed:21288892, ECO:0000269\|PubMed:21671571, ECO:0007744\|PDB:2AFM, ECO:0007744\|PDB:2AFO, ECO:0007744\|PDB:2AFS, ECO:0007744\|PDB:2AFU, ECO:0007744\|PDB:2AFW, ECO:0007744\|PDB:2AFX, ECO:0007744\|PDB:2AFZ, ECO:0007744\|PDB:2ZED, ECO:0007744\|PDB:2ZEE, ECO:0007744\|PDB:2ZEF, ECO:0007744\|PDB:2ZEG, ECO:0007744\|PDB:2ZEH, ECO:0007744\|PDB:2ZEL, ECO:0007744\|PDB:2ZEM, ECO:0007744\|PDB:2ZEN, ECO:0007744\|PDB:2ZEO, ECO:0007744\|PDB:2ZEP, ECO:0007744\|PDB:3PBB, ECO:0007744\|PDB:3PBE, ECO:0007744\|PDB:3SI0, ECO:0007744\|PDB:4YU9, ECO:0007744\|PDB:4YWY

Chain	Residue	Details
B	ASP159
D	ASP159
D	GLU202
D	HIS330
E	ASP159
E	GLU202
E	HIS330
F	ASP159
F	GLU202
F	HIS330
G	ASP159
B	GLU202
G	GLU202
G	HIS330
H	ASP159
H	GLU202
H	HIS330
I	ASP159
I	GLU202
I	HIS330
J	ASP159
J	GLU202
B	HIS330
J	HIS330
K	ASP159
K	GLU202
K	HIS330
L	ASP159
L	GLU202
L	HIS330
A	ASP159
A	GLU202
A	HIS330
C	ASP159
C	GLU202
C	HIS330

site_id	SWS_FT_FI3
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:21671571

Chain	Residue	Details
B	ASN49
J	ASN49
K	ASN49
L	ASN49
A	ASN49
C	ASN49
D	ASN49
E	ASN49
F	ASN49
G	ASN49
H	ASN49
I	ASN49

site_id	SWS_FT_FI4
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN296
J	ASN296
K	ASN296
L	ASN296
A	ASN296
C	ASN296
D	ASN296
E	ASN296
F	ASN296
G	ASN296
H	ASN296
I	ASN296

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)