8XGR

ETB-eGt complex bound to endothelin-1

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0001750	cellular_component	photoreceptor outer segment
B	0001917	cellular_component	photoreceptor inner segment
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005834	cellular_component	heterotrimeric G-protein complex
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
B	0008283	biological_process	cell population proliferation
B	0010659	biological_process	cardiac muscle cell apoptotic process
B	0030159	molecular_function	signaling receptor complex adaptor activity
B	0030425	cellular_component	dendrite
B	0030507	molecular_function	spectrin binding
B	0042622	cellular_component	photoreceptor outer segment membrane
B	0044297	cellular_component	cell body
B	0044877	molecular_function	protein-containing complex binding
B	0045202	cellular_component	synapse
B	0047391	molecular_function	alkylglycerophosphoethanolamine phosphodiesterase activity
B	0050909	biological_process	sensory perception of taste
B	0051020	molecular_function	GTPase binding
B	0060041	biological_process	retina development in camera-type eye
B	0071456	biological_process	cellular response to hypoxia
G	0000035	molecular_function	acyl binding
G	0000166	molecular_function	nucleotide binding
G	0001664	molecular_function	G protein-coupled receptor binding
G	0001750	cellular_component	photoreceptor outer segment
G	0001917	cellular_component	photoreceptor inner segment
G	0003924	molecular_function	GTPase activity
G	0003925	molecular_function	G protein activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005834	cellular_component	heterotrimeric G-protein complex
G	0005886	cellular_component	plasma membrane
G	0007165	biological_process	signal transduction
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
G	0007601	biological_process	visual perception
G	0007602	biological_process	phototransduction
G	0007603	biological_process	phototransduction, visible light
G	0009416	biological_process	response to light stimulus
G	0016020	cellular_component	membrane
G	0019001	molecular_function	guanyl nucleotide binding
G	0019003	molecular_function	GDP binding
G	0019901	molecular_function	protein kinase binding
G	0031681	molecular_function	G-protein beta-subunit binding
G	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
G	0042622	cellular_component	photoreceptor outer segment membrane
G	0046872	molecular_function	metal ion binding
G	0050908	biological_process	detection of light stimulus involved in visual perception
G	0051344	biological_process	negative regulation of cyclic-nucleotide phosphodiesterase activity
G	0071380	biological_process	cellular response to prostaglandin E stimulus
G	0071870	biological_process	cellular response to catecholamine stimulus
G	0097381	cellular_component	photoreceptor disc membrane
G	0097648	cellular_component	G protein-coupled receptor complex
G	0141190	biological_process	transducin-mediated opsin signaling pathway
L	0005576	cellular_component	extracellular region
L	0019229	biological_process	regulation of vasoconstriction
R	0000122	biological_process	negative regulation of transcription by RNA polymerase II
R	0002001	biological_process	renin secretion into blood stream
R	0002027	biological_process	regulation of heart rate
R	0004930	molecular_function	G protein-coupled receptor activity
R	0004962	molecular_function	endothelin receptor activity
R	0005515	molecular_function	protein binding
R	0005886	cellular_component	plasma membrane
R	0006182	biological_process	cGMP biosynthetic process
R	0007165	biological_process	signal transduction
R	0007166	biological_process	cell surface receptor signaling pathway
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007194	biological_process	negative regulation of adenylate cyclase activity
R	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
R	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
R	0007399	biological_process	nervous system development
R	0008217	biological_process	regulation of blood pressure
R	0008284	biological_process	positive regulation of cell population proliferation
R	0010467	biological_process	gene expression
R	0014043	biological_process	negative regulation of neuron maturation
R	0014826	biological_process	vein smooth muscle contraction
R	0014829	biological_process	vascular associated smooth muscle contraction
R	0016020	cellular_component	membrane
R	0017046	molecular_function	peptide hormone binding
R	0019722	biological_process	calcium-mediated signaling
R	0030202	biological_process	heparin proteoglycan metabolic process
R	0030318	biological_process	melanocyte differentiation
R	0031620	biological_process	regulation of fever generation
R	0031702	molecular_function	type 1 angiotensin receptor binding
R	0031965	cellular_component	nuclear membrane
R	0032341	biological_process	aldosterone metabolic process
R	0032496	biological_process	response to lipopolysaccharide
R	0035645	biological_process	enteric smooth muscle cell differentiation
R	0035810	biological_process	positive regulation of urine volume
R	0035812	biological_process	renal sodium excretion
R	0042045	biological_process	epithelial fluid transport
R	0042310	biological_process	vasoconstriction
R	0042311	biological_process	vasodilation
R	0043066	biological_process	negative regulation of apoptotic process
R	0043473	biological_process	pigmentation
R	0048066	biological_process	developmental pigmentation
R	0048246	biological_process	macrophage chemotaxis
R	0048265	biological_process	response to pain
R	0048484	biological_process	enteric nervous system development
R	0050678	biological_process	regulation of epithelial cell proliferation
R	0051248	biological_process	negative regulation of protein metabolic process
R	0055078	biological_process	sodium ion homeostasis
R	0060070	biological_process	canonical Wnt signaling pathway
R	0060406	biological_process	positive regulation of penile erection
R	0061028	biological_process	establishment of endothelial barrier
R	0070294	biological_process	renal sodium ion absorption
R	0070588	biological_process	calcium ion transmembrane transport
R	0071222	biological_process	cellular response to lipopolysaccharide
R	0071806	biological_process	protein transmembrane transport
R	0072112	biological_process	podocyte differentiation
R	0086100	biological_process	endothelin receptor signaling pathway
R	0097018	biological_process	renal albumin absorption
R	0160093	biological_process	chordate pharynx development
R	1904383	biological_process	response to sodium phosphate
R	1990839	biological_process	response to endothelin

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ITVlSLCALSIDRYRaV

Chain	Residue	Details
R	ILE187-VAL203

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site_id	PS00270
Number of Residues	15
Details	ENDOTHELIN Endothelin family signature. CsCsslmDkeCvyFC

Chain	Residue	Details
L	CYS1-CYS15

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site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
B	LEU70-SER84
B	ILE157-ILE171
B	LEU285-ALA299
B	VAL327-GLY341

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Peptide: {"description":"Endothelin-1","featureId":"PRO_0000008060","evidences":[{"source":"PubMed","id":"10438732","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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