8XGR

ETB-eGt complex bound to endothelin-1

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0003924	molecular_function	GTPase activity
G	0005515	molecular_function	protein binding
G	0005834	cellular_component	heterotrimeric G-protein complex
G	0005886	cellular_component	plasma membrane
G	0007165	biological_process	signal transduction
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
G	0016020	cellular_component	membrane
G	0031681	molecular_function	G-protein beta-subunit binding
G	0071380	biological_process	cellular response to prostaglandin E stimulus
G	0071870	biological_process	cellular response to catecholamine stimulus

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
B	LEU70-SER84
B	ILE157-ILE171
B	LEU285-ALA299
B	VAL327-GLY341

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site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ITVlSLCALSIDRYRaV

Chain	Residue	Details
R	ILE187-VAL203

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site_id	PS00270
Number of Residues	15
Details	ENDOTHELIN Endothelin family signature. CsCsslmDkeCvyFC

Chain	Residue	Details
L	CYS1-CYS15

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by KEL => ECO:0000269|PubMed:10438732

Chain	Residue	Details
L	TRP21

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Cysteine methyl ester => ECO:0000269|PubMed:1903391

Chain	Residue	Details
G	CYS68

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site_id	SWS_FT_FI3
Number of Residues	1
Details	LIPID: S-geranylgeranyl cysteine => ECO:0000269|PubMed:12764189, ECO:0000269|PubMed:1903391, ECO:0000269|PubMed:7626050

Chain	Residue	Details
G	CYS68

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