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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8XGR

ETB-eGt complex bound to endothelin-1

Functional Information from GO Data
ChainGOidnamespacecontents
B0001917cellular_componentphotoreceptor inner segment
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0010659biological_processcardiac muscle cell apoptotic process
B0030159molecular_functionsignaling receptor complex adaptor activity
B0030425cellular_componentdendrite
B0030507molecular_functionspectrin binding
B0042622cellular_componentphotoreceptor outer segment membrane
B0044297cellular_componentcell body
B0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
B0071456biological_processcellular response to hypoxia
G0000035molecular_functionacyl binding
G0001664molecular_functionG protein-coupled receptor binding
G0001750cellular_componentphotoreceptor outer segment
G0001917cellular_componentphotoreceptor inner segment
G0003924molecular_functionGTPase activity
G0003925molecular_functionG protein activity
G0005515molecular_functionprotein binding
G0005525molecular_functionGTP binding
G0005737cellular_componentcytoplasm
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0007602biological_processphototransduction
G0007603biological_processphototransduction, visible light
G0009416biological_processresponse to light stimulus
G0016020cellular_componentmembrane
G0019001molecular_functionguanyl nucleotide binding
G0019003molecular_functionGDP binding
G0019901molecular_functionprotein kinase binding
G0031681molecular_functionG-protein beta-subunit binding
G0031683molecular_functionG-protein beta/gamma-subunit complex binding
G0042622cellular_componentphotoreceptor outer segment membrane
G0050908biological_processdetection of light stimulus involved in visual perception
G0051344biological_processnegative regulation of cyclic-nucleotide phosphodiesterase activity
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
G0097381cellular_componentphotoreceptor disc membrane
G0097648cellular_componentG protein-coupled receptor complex
G0141190biological_processtransducin-mediated opsin signaling pathway
L0005576cellular_componentextracellular region
L0019229biological_processregulation of vasoconstriction
R0000122biological_processnegative regulation of transcription by RNA polymerase II
R0002001biological_processrenin secretion into blood stream
R0002027biological_processregulation of heart rate
R0004930molecular_functionG protein-coupled receptor activity
R0004962molecular_functionendothelin receptor activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0006182biological_processcGMP biosynthetic process
R0007166biological_processcell surface receptor signaling pathway
R0007186biological_processG protein-coupled receptor signaling pathway
R0007194biological_processnegative regulation of adenylate cyclase activity
R0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0007399biological_processnervous system development
R0008217biological_processregulation of blood pressure
R0008284biological_processpositive regulation of cell population proliferation
R0010467biological_processgene expression
R0014043biological_processnegative regulation of neuron maturation
R0014826biological_processvein smooth muscle contraction
R0014829biological_processvascular associated smooth muscle contraction
R0016020cellular_componentmembrane
R0017046molecular_functionpeptide hormone binding
R0019722biological_processcalcium-mediated signaling
R0030318biological_processmelanocyte differentiation
R0031620biological_processregulation of fever generation
R0031702molecular_functiontype 1 angiotensin receptor binding
R0031965cellular_componentnuclear membrane
R0032341biological_processaldosterone metabolic process
R0032496biological_processresponse to lipopolysaccharide
R0035645biological_processenteric smooth muscle cell differentiation
R0035810biological_processpositive regulation of urine volume
R0035812biological_processrenal sodium excretion
R0042045biological_processepithelial fluid transport
R0042310biological_processvasoconstriction
R0042311biological_processvasodilation
R0043066biological_processnegative regulation of apoptotic process
R0043473biological_processpigmentation
R0048066biological_processdevelopmental pigmentation
R0048246biological_processmacrophage chemotaxis
R0048265biological_processresponse to pain
R0048484biological_processenteric nervous system development
R0050678biological_processregulation of epithelial cell proliferation
R0051248biological_processnegative regulation of protein metabolic process
R0055078biological_processsodium ion homeostasis
R0060070biological_processcanonical Wnt signaling pathway
R0060406biological_processpositive regulation of penile erection
R0070294biological_processrenal sodium ion absorption
R0070588biological_processcalcium ion transmembrane transport
R0071222biological_processcellular response to lipopolysaccharide
R0086100biological_processendothelin receptor signaling pathway
R0160093biological_processchordate pharynx development
R1904383biological_processresponse to sodium phosphate
R1990839biological_processresponse to endothelin
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ITVlSLCALSIDRYRaV
ChainResidueDetails
RILE187-VAL203
site_idPS00270
Number of Residues15
DetailsENDOTHELIN Endothelin family signature. CsCsslmDkeCvyFC
ChainResidueDetails
LCYS1-CYS15
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299
BVAL327-GLY341
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues13
DetailsRegion: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues9
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues7
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues5
DetailsRegion: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues10
DetailsRegion: {"description":"Interaction with RHO","evidences":[{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389988","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9539726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"7969474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8208289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8259210","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FQJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GOT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TND","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V00","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"8259210","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TND","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"7969474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8208289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8259210","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GOT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TND","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues48
DetailsRepeat: {"description":"WD 1","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues45
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues40
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues41
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues43
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues41
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues30
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues30
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues49
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues26
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues1
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"9261180","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues1
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues20
DetailsPeptide: {"description":"Endothelin-1","featureId":"PRO_0000008060","evidences":[{"source":"PubMed","id":"10438732","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2026-04-01

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