8XGC

Structure of yeast replisome associated with FACT and histone hexamer, Composite map

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000166	molecular_function	nucleotide binding
2	0000727	biological_process	double-strand break repair via break-induced replication
2	0003677	molecular_function	DNA binding
2	0003678	molecular_function	DNA helicase activity
2	0003682	molecular_function	chromatin binding
2	0003688	molecular_function	DNA replication origin binding
2	0003697	molecular_function	single-stranded DNA binding
2	0004386	molecular_function	helicase activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005656	cellular_component	nuclear pre-replicative complex
2	0005737	cellular_component	cytoplasm
2	0006260	biological_process	DNA replication
2	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
2	0006270	biological_process	DNA replication initiation
2	0006271	biological_process	DNA strand elongation involved in DNA replication
2	0006279	biological_process	premeiotic DNA replication
2	0006974	biological_process	DNA damage response
2	0008270	molecular_function	zinc ion binding
2	0016787	molecular_function	hydrolase activity
2	0016887	molecular_function	ATP hydrolysis activity
2	0017116	molecular_function	single-stranded DNA helicase activity
2	0031261	cellular_component	DNA replication preinitiation complex
2	0042555	cellular_component	MCM complex
2	0043138	molecular_function	3'-5' DNA helicase activity
2	0043596	cellular_component	nuclear replication fork
2	0046872	molecular_function	metal ion binding
2	0071162	cellular_component	CMG complex
2	1902975	biological_process	mitotic DNA replication initiation
3	0000166	molecular_function	nucleotide binding
3	0000727	biological_process	double-strand break repair via break-induced replication
3	0000781	cellular_component	chromosome, telomeric region
3	0003677	molecular_function	DNA binding
3	0003678	molecular_function	DNA helicase activity
3	0003682	molecular_function	chromatin binding
3	0003688	molecular_function	DNA replication origin binding
3	0003697	molecular_function	single-stranded DNA binding
3	0004386	molecular_function	helicase activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005656	cellular_component	nuclear pre-replicative complex
3	0005737	cellular_component	cytoplasm
3	0006260	biological_process	DNA replication
3	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
3	0006270	biological_process	DNA replication initiation
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0006279	biological_process	premeiotic DNA replication
3	0016787	molecular_function	hydrolase activity
3	0016887	molecular_function	ATP hydrolysis activity
3	0017116	molecular_function	single-stranded DNA helicase activity
3	0030466	biological_process	silent mating-type cassette heterochromatin formation
3	0031261	cellular_component	DNA replication preinitiation complex
3	0031509	biological_process	subtelomeric heterochromatin formation
3	0042555	cellular_component	MCM complex
3	0043596	cellular_component	nuclear replication fork
3	0071162	cellular_component	CMG complex
3	1902975	biological_process	mitotic DNA replication initiation
3	1904931	molecular_function	MCM complex binding
4	0000166	molecular_function	nucleotide binding
4	0000727	biological_process	double-strand break repair via break-induced replication
4	0003677	molecular_function	DNA binding
4	0003678	molecular_function	DNA helicase activity
4	0003688	molecular_function	DNA replication origin binding
4	0003697	molecular_function	single-stranded DNA binding
4	0004386	molecular_function	helicase activity
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005656	cellular_component	nuclear pre-replicative complex
4	0005737	cellular_component	cytoplasm
4	0006260	biological_process	DNA replication
4	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
4	0006270	biological_process	DNA replication initiation
4	0006271	biological_process	DNA strand elongation involved in DNA replication
4	0006279	biological_process	premeiotic DNA replication
4	0008270	molecular_function	zinc ion binding
4	0009378	molecular_function	four-way junction helicase activity
4	0016787	molecular_function	hydrolase activity
4	0016887	molecular_function	ATP hydrolysis activity
4	0017116	molecular_function	single-stranded DNA helicase activity
4	0031261	cellular_component	DNA replication preinitiation complex
4	0033260	biological_process	nuclear DNA replication
4	0042555	cellular_component	MCM complex
4	0043138	molecular_function	3'-5' DNA helicase activity
4	0043596	cellular_component	nuclear replication fork
4	0071162	cellular_component	CMG complex
4	0097373	cellular_component	MCM core complex
4	1902975	biological_process	mitotic DNA replication initiation
5	0000166	molecular_function	nucleotide binding
5	0000727	biological_process	double-strand break repair via break-induced replication
5	0000781	cellular_component	chromosome, telomeric region
5	0003677	molecular_function	DNA binding
5	0003678	molecular_function	DNA helicase activity
5	0003682	molecular_function	chromatin binding
5	0003688	molecular_function	DNA replication origin binding
5	0003697	molecular_function	single-stranded DNA binding
5	0004386	molecular_function	helicase activity
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005656	cellular_component	nuclear pre-replicative complex
5	0005737	cellular_component	cytoplasm
5	0006260	biological_process	DNA replication
5	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
5	0006270	biological_process	DNA replication initiation
5	0006279	biological_process	premeiotic DNA replication
5	0006368	biological_process	transcription elongation by RNA polymerase II
5	0008270	molecular_function	zinc ion binding
5	0016787	molecular_function	hydrolase activity
5	0016887	molecular_function	ATP hydrolysis activity
5	0017116	molecular_function	single-stranded DNA helicase activity
5	0030174	biological_process	regulation of DNA-templated DNA replication initiation
5	0031261	cellular_component	DNA replication preinitiation complex
5	0031507	biological_process	heterochromatin formation
5	0031509	biological_process	subtelomeric heterochromatin formation
5	0033260	biological_process	nuclear DNA replication
5	0042555	cellular_component	MCM complex
5	0043138	molecular_function	3'-5' DNA helicase activity
5	0043596	cellular_component	nuclear replication fork
5	0071162	cellular_component	CMG complex
6	0000166	molecular_function	nucleotide binding
6	0000727	biological_process	double-strand break repair via break-induced replication
6	0003677	molecular_function	DNA binding
6	0003678	molecular_function	DNA helicase activity
6	0003688	molecular_function	DNA replication origin binding
6	0003697	molecular_function	single-stranded DNA binding
6	0004386	molecular_function	helicase activity
6	0005515	molecular_function	protein binding
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005656	cellular_component	nuclear pre-replicative complex
6	0005737	cellular_component	cytoplasm
6	0005777	cellular_component	peroxisome
6	0006260	biological_process	DNA replication
6	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
6	0006270	biological_process	DNA replication initiation
6	0006271	biological_process	DNA strand elongation involved in DNA replication
6	0006279	biological_process	premeiotic DNA replication
6	0008270	molecular_function	zinc ion binding
6	0009378	molecular_function	four-way junction helicase activity
6	0016787	molecular_function	hydrolase activity
6	0016887	molecular_function	ATP hydrolysis activity
6	0017116	molecular_function	single-stranded DNA helicase activity
6	0031261	cellular_component	DNA replication preinitiation complex
6	0042555	cellular_component	MCM complex
6	0043138	molecular_function	3'-5' DNA helicase activity
6	0043596	cellular_component	nuclear replication fork
6	0071162	cellular_component	CMG complex
6	0097373	cellular_component	MCM core complex
6	1902969	biological_process	mitotic DNA replication
6	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
7	0000166	molecular_function	nucleotide binding
7	0000727	biological_process	double-strand break repair via break-induced replication
7	0000781	cellular_component	chromosome, telomeric region
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0003682	molecular_function	chromatin binding
7	0003688	molecular_function	DNA replication origin binding
7	0003697	molecular_function	single-stranded DNA binding
7	0004386	molecular_function	helicase activity
7	0005515	molecular_function	protein binding
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005656	cellular_component	nuclear pre-replicative complex
7	0005737	cellular_component	cytoplasm
7	0006260	biological_process	DNA replication
7	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
7	0006270	biological_process	DNA replication initiation
7	0006271	biological_process	DNA strand elongation involved in DNA replication
7	0006279	biological_process	premeiotic DNA replication
7	0008270	molecular_function	zinc ion binding
7	0009378	molecular_function	four-way junction helicase activity
7	0016787	molecular_function	hydrolase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0017116	molecular_function	single-stranded DNA helicase activity
7	0030466	biological_process	silent mating-type cassette heterochromatin formation
7	0031261	cellular_component	DNA replication preinitiation complex
7	0031509	biological_process	subtelomeric heterochromatin formation
7	0033260	biological_process	nuclear DNA replication
7	0042555	cellular_component	MCM complex
7	0043138	molecular_function	3'-5' DNA helicase activity
7	0043596	cellular_component	nuclear replication fork
7	0071162	cellular_component	CMG complex
7	0097373	cellular_component	MCM core complex
7	1904931	molecular_function	MCM complex binding
8	0000166	molecular_function	nucleotide binding
8	0000278	biological_process	mitotic cell cycle
8	0003676	molecular_function	nucleic acid binding
8	0003677	molecular_function	DNA binding
8	0003690	molecular_function	double-stranded DNA binding
8	0003697	molecular_function	single-stranded DNA binding
8	0003729	molecular_function	mRNA binding
8	0003887	molecular_function	DNA-directed DNA polymerase activity
8	0005515	molecular_function	protein binding
8	0005634	cellular_component	nucleus
8	0005657	cellular_component	replication fork
8	0006260	biological_process	DNA replication
8	0006261	biological_process	DNA-templated DNA replication
8	0006272	biological_process	leading strand elongation
8	0006281	biological_process	DNA repair
8	0006284	biological_process	base-excision repair
8	0006287	biological_process	base-excision repair, gap-filling
8	0006297	biological_process	nucleotide-excision repair, DNA gap filling
8	0006302	biological_process	double-strand break repair
8	0006303	biological_process	double-strand break repair via nonhomologous end joining
8	0007064	biological_process	mitotic sister chromatid cohesion
8	0008270	molecular_function	zinc ion binding
8	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
8	0008622	cellular_component	epsilon DNA polymerase complex
8	0016740	molecular_function	transferase activity
8	0016779	molecular_function	nucleotidyltransferase activity
8	0016787	molecular_function	hydrolase activity
8	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
8	0032183	molecular_function	SUMO binding
8	0033314	biological_process	mitotic DNA replication checkpoint signaling
8	0034061	molecular_function	DNA polymerase activity
8	0035822	biological_process	gene conversion
8	0042276	biological_process	error-prone translesion synthesis
8	0043596	cellular_component	nuclear replication fork
8	0045004	biological_process	DNA replication proofreading
8	0046872	molecular_function	metal ion binding
8	0051536	molecular_function	iron-sulfur cluster binding
8	0051539	molecular_function	4 iron, 4 sulfur cluster binding
9	0003677	molecular_function	DNA binding
9	0003690	molecular_function	double-stranded DNA binding
9	0003697	molecular_function	single-stranded DNA binding
9	0003887	molecular_function	DNA-directed DNA polymerase activity
9	0005515	molecular_function	protein binding
9	0005634	cellular_component	nucleus
9	0005694	cellular_component	chromosome
9	0005737	cellular_component	cytoplasm
9	0006260	biological_process	DNA replication
9	0006261	biological_process	DNA-templated DNA replication
9	0008622	cellular_component	epsilon DNA polymerase complex
9	0030337	molecular_function	DNA polymerase processivity factor activity
9	0031981	cellular_component	nuclear lumen
9	0042276	biological_process	error-prone translesion synthesis
9	0043596	cellular_component	nuclear replication fork
9	0045005	biological_process	DNA-templated DNA replication maintenance of fidelity
A	0000727	biological_process	double-strand break repair via break-induced replication
A	0000811	cellular_component	GINS complex
A	0003674	molecular_function	molecular_function
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0031261	cellular_component	DNA replication preinitiation complex
A	0043596	cellular_component	nuclear replication fork
A	0071162	cellular_component	CMG complex
A	1902983	biological_process	DNA strand elongation involved in mitotic DNA replication
B	0000228	cellular_component	nuclear chromosome
B	0000727	biological_process	double-strand break repair via break-induced replication
B	0000811	cellular_component	GINS complex
B	0003674	molecular_function	molecular_function
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0031261	cellular_component	DNA replication preinitiation complex
B	0043596	cellular_component	nuclear replication fork
B	0071162	cellular_component	CMG complex
C	0000727	biological_process	double-strand break repair via break-induced replication
C	0000811	cellular_component	GINS complex
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0006260	biological_process	DNA replication
C	0006261	biological_process	DNA-templated DNA replication
C	0006270	biological_process	DNA replication initiation
C	0031261	cellular_component	DNA replication preinitiation complex
C	0043596	cellular_component	nuclear replication fork
C	0071162	cellular_component	CMG complex
D	0000727	biological_process	double-strand break repair via break-induced replication
D	0000811	cellular_component	GINS complex
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0031261	cellular_component	DNA replication preinitiation complex
D	0043596	cellular_component	nuclear replication fork
D	0071162	cellular_component	CMG complex
E	0000727	biological_process	double-strand break repair via break-induced replication
E	0003682	molecular_function	chromatin binding
E	0003688	molecular_function	DNA replication origin binding
E	0003697	molecular_function	single-stranded DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0006260	biological_process	DNA replication
E	0006270	biological_process	DNA replication initiation
E	0031261	cellular_component	DNA replication preinitiation complex
E	0043596	cellular_component	nuclear replication fork
E	0071162	cellular_component	CMG complex
E	1902977	biological_process	mitotic DNA replication preinitiation complex assembly
F	0000228	cellular_component	nuclear chromosome
F	0000278	biological_process	mitotic cell cycle
F	0000727	biological_process	double-strand break repair via break-induced replication
F	0003682	molecular_function	chromatin binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0006260	biological_process	DNA replication
F	0006261	biological_process	DNA-templated DNA replication
F	0006270	biological_process	DNA replication initiation
F	0006281	biological_process	DNA repair
F	0006334	biological_process	nucleosome assembly
F	0007064	biological_process	mitotic sister chromatid cohesion
F	0034085	biological_process	establishment of sister chromatid cohesion
F	0042802	molecular_function	identical protein binding
F	0043596	cellular_component	nuclear replication fork
G	0000228	cellular_component	nuclear chromosome
G	0000278	biological_process	mitotic cell cycle
G	0000727	biological_process	double-strand break repair via break-induced replication
G	0003682	molecular_function	chromatin binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0006260	biological_process	DNA replication
G	0006261	biological_process	DNA-templated DNA replication
G	0006270	biological_process	DNA replication initiation
G	0006281	biological_process	DNA repair
G	0006334	biological_process	nucleosome assembly
G	0007064	biological_process	mitotic sister chromatid cohesion
G	0034085	biological_process	establishment of sister chromatid cohesion
G	0042802	molecular_function	identical protein binding
G	0043596	cellular_component	nuclear replication fork
H	0000228	cellular_component	nuclear chromosome
H	0000278	biological_process	mitotic cell cycle
H	0000727	biological_process	double-strand break repair via break-induced replication
H	0003682	molecular_function	chromatin binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0006260	biological_process	DNA replication
H	0006261	biological_process	DNA-templated DNA replication
H	0006270	biological_process	DNA replication initiation
H	0006281	biological_process	DNA repair
H	0006334	biological_process	nucleosome assembly
H	0007064	biological_process	mitotic sister chromatid cohesion
H	0034085	biological_process	establishment of sister chromatid cohesion
H	0042802	molecular_function	identical protein binding
H	0043596	cellular_component	nuclear replication fork
I	0000076	biological_process	DNA replication checkpoint signaling
I	0003674	molecular_function	molecular_function
I	0003677	molecular_function	DNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005829	cellular_component	cytosol
I	0006260	biological_process	DNA replication
I	0006281	biological_process	DNA repair
I	0006974	biological_process	DNA damage response
I	0007064	biological_process	mitotic sister chromatid cohesion
I	0008156	biological_process	negative regulation of DNA replication
I	0031297	biological_process	replication fork processing
I	0031298	cellular_component	replication fork protection complex
I	0043111	biological_process	replication fork arrest
I	0043570	biological_process	maintenance of DNA repeat elements
I	0043596	cellular_component	nuclear replication fork
I	0051321	biological_process	meiotic cell cycle
J	0000076	biological_process	DNA replication checkpoint signaling
J	0003674	molecular_function	molecular_function
J	0003677	molecular_function	DNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0006281	biological_process	DNA repair
J	0006974	biological_process	DNA damage response
J	0007064	biological_process	mitotic sister chromatid cohesion
J	0008156	biological_process	negative regulation of DNA replication
J	0031297	biological_process	replication fork processing
J	0031298	cellular_component	replication fork protection complex
J	0034087	biological_process	establishment of mitotic sister chromatid cohesion
J	0043111	biological_process	replication fork arrest
J	0043570	biological_process	maintenance of DNA repeat elements
J	0043596	cellular_component	nuclear replication fork
J	0045132	biological_process	meiotic chromosome segregation
J	0051321	biological_process	meiotic cell cycle
K	0000076	biological_process	DNA replication checkpoint signaling
K	0000723	biological_process	telomere maintenance
K	0000781	cellular_component	chromosome, telomeric region
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0006260	biological_process	DNA replication
K	0006281	biological_process	DNA repair
K	0007064	biological_process	mitotic sister chromatid cohesion
K	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
K	0010997	molecular_function	anaphase-promoting complex binding
K	0030466	biological_process	silent mating-type cassette heterochromatin formation
K	0031297	biological_process	replication fork processing
K	0031298	cellular_component	replication fork protection complex
K	0031509	biological_process	subtelomeric heterochromatin formation
K	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
K	0033262	biological_process	regulation of nuclear cell cycle DNA replication
K	0033314	biological_process	mitotic DNA replication checkpoint signaling
K	0034399	cellular_component	nuclear periphery
K	0043570	biological_process	maintenance of DNA repeat elements
K	0043596	cellular_component	nuclear replication fork
K	0050821	biological_process	protein stabilization
K	0071470	biological_process	cellular response to osmotic stress
K	0140713	molecular_function	histone chaperone activity
L	0000785	cellular_component	chromatin
L	0003682	molecular_function	chromatin binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005694	cellular_component	chromosome
L	0006260	biological_process	DNA replication
L	0006261	biological_process	DNA-templated DNA replication
L	0006281	biological_process	DNA repair
L	0006325	biological_process	chromatin organization
L	0006334	biological_process	nucleosome assembly
L	0006337	biological_process	nucleosome disassembly
L	0006351	biological_process	DNA-templated transcription
L	0006974	biological_process	DNA damage response
L	0007063	biological_process	regulation of sister chromatid cohesion
L	0010468	biological_process	regulation of gene expression
L	0031491	molecular_function	nucleosome binding
L	0032784	biological_process	regulation of DNA-templated transcription elongation
L	0034728	biological_process	nucleosome organization
L	0035101	cellular_component	FACT complex
L	0042393	molecular_function	histone binding
L	0042802	molecular_function	identical protein binding
L	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
L	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
L	1902275	biological_process	regulation of chromatin organization
M	0000785	cellular_component	chromatin
M	0003677	molecular_function	DNA binding
M	0003682	molecular_function	chromatin binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005694	cellular_component	chromosome
M	0006260	biological_process	DNA replication
M	0006261	biological_process	DNA-templated DNA replication
M	0006281	biological_process	DNA repair
M	0006325	biological_process	chromatin organization
M	0006351	biological_process	DNA-templated transcription
M	0006974	biological_process	DNA damage response
M	0031491	molecular_function	nucleosome binding
M	0034728	biological_process	nucleosome organization
M	0035101	cellular_component	FACT complex
M	0042393	molecular_function	histone binding
M	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
M	1902275	biological_process	regulation of chromatin organization
N	0000776	cellular_component	kinetochore
N	0000786	cellular_component	nucleosome
N	0003677	molecular_function	DNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005694	cellular_component	chromosome
N	0006325	biological_process	chromatin organization
N	0006355	biological_process	regulation of DNA-templated transcription
N	0006878	biological_process	intracellular copper ion homeostasis
N	0007080	biological_process	mitotic metaphase chromosome alignment
N	0008823	molecular_function	cupric reductase (NADH) activity
N	0009060	biological_process	aerobic respiration
N	0009303	biological_process	rRNA transcription
N	0030527	molecular_function	structural constituent of chromatin
N	0031492	molecular_function	nucleosomal DNA binding
N	0031507	biological_process	heterochromatin formation
N	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
N	0042802	molecular_function	identical protein binding
N	0043505	cellular_component	CENP-A containing nucleosome
N	0043935	biological_process	sexual sporulation resulting in formation of a cellular spore
N	0045943	biological_process	positive regulation of transcription by RNA polymerase I
N	0046982	molecular_function	protein heterodimerization activity
N	0051382	biological_process	kinetochore assembly
N	0070911	biological_process	global genome nucleotide-excision repair
O	0000786	cellular_component	nucleosome
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005694	cellular_component	chromosome
O	0006325	biological_process	chromatin organization
O	0006334	biological_process	nucleosome assembly
O	0006355	biological_process	regulation of DNA-templated transcription
O	0030527	molecular_function	structural constituent of chromatin
O	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
O	0042802	molecular_function	identical protein binding
O	0045943	biological_process	positive regulation of transcription by RNA polymerase I
O	0046982	molecular_function	protein heterodimerization activity
P	0000122	biological_process	negative regulation of transcription by RNA polymerase II
P	0000786	cellular_component	nucleosome
P	0003677	molecular_function	DNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005694	cellular_component	chromosome
P	0006281	biological_process	DNA repair
P	0006325	biological_process	chromatin organization
P	0006974	biological_process	DNA damage response
P	0030527	molecular_function	structural constituent of chromatin
P	0031507	biological_process	heterochromatin formation
P	0046982	molecular_function	protein heterodimerization activity
Q	0000786	cellular_component	nucleosome
Q	0003677	molecular_function	DNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005694	cellular_component	chromosome
Q	0006325	biological_process	chromatin organization
Q	0006355	biological_process	regulation of DNA-templated transcription
Q	0030527	molecular_function	structural constituent of chromatin
Q	0046982	molecular_function	protein heterodimerization activity
R	0000776	cellular_component	kinetochore
R	0000786	cellular_component	nucleosome
R	0003677	molecular_function	DNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005694	cellular_component	chromosome
R	0006325	biological_process	chromatin organization
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006878	biological_process	intracellular copper ion homeostasis
R	0007080	biological_process	mitotic metaphase chromosome alignment
R	0008823	molecular_function	cupric reductase (NADH) activity
R	0009060	biological_process	aerobic respiration
R	0009303	biological_process	rRNA transcription
R	0030527	molecular_function	structural constituent of chromatin
R	0031492	molecular_function	nucleosomal DNA binding
R	0031507	biological_process	heterochromatin formation
R	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
R	0042802	molecular_function	identical protein binding
R	0043505	cellular_component	CENP-A containing nucleosome
R	0043935	biological_process	sexual sporulation resulting in formation of a cellular spore
R	0045943	biological_process	positive regulation of transcription by RNA polymerase I
R	0046982	molecular_function	protein heterodimerization activity
R	0051382	biological_process	kinetochore assembly
R	0070911	biological_process	global genome nucleotide-excision repair
S	0000786	cellular_component	nucleosome
S	0003677	molecular_function	DNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005694	cellular_component	chromosome
S	0006325	biological_process	chromatin organization
S	0006334	biological_process	nucleosome assembly
S	0006355	biological_process	regulation of DNA-templated transcription
S	0030527	molecular_function	structural constituent of chromatin
S	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
S	0042802	molecular_function	identical protein binding
S	0045943	biological_process	positive regulation of transcription by RNA polymerase I
S	0046982	molecular_function	protein heterodimerization activity

Functional Information from PROSITE/UniProt

site_id	PS00014
Number of Residues	4
Details	ER_TARGET Endoplasmic reticulum targeting sequence. SQEL

Chain	Residue	Details
P	SER129-LEU132

---

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLtFPV

Chain	Residue	Details
P	ALA23-VAL29

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
S	GLY15-HIS19

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
N	LYS15-LEU21

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlILpGELaKHAVSEG

Chain	Residue	Details
Q	ARG96-GLY118

---

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GVCLIDEFD

Chain	Residue	Details
2	GLY602-ASP610
3	GLY468-ASP476
4	GLY627-ASP635
7	GLY519-ASP527
6	GLY634-ASP642
5	GLY475-ASP483

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
N	PRO67-ILE75

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	621
Details	Domain: {"description":"MCM"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	26
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	19
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	Motif: {"description":"Arginine finger"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Compositional bias: {"description":"Acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	35
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P33993","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	25
Details	Zinc finger: {"description":"CysA-type","evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	17
Details	Motif: {"description":"CysB motif","evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"14747467","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	120
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	30
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	16
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	6
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"16768447","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	Modified residue: {"description":"N6-glutaryllysine","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	Modified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"24352239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"12535538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12535539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14660635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15280549","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---