8XER
Cryo-EM structure of integrin ITGAV, ITGB3 and Cilengitide TFA complex, conformation 1
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS00022 |
| Number of Residues | 12 |
| Details | EGF_1 EGF-like domain signature 1. CrCgpGwlGSqC |
| Chain | Residue | Details |
| B | CYS486-CYS497 | |
| B | CYS573-CYS584 |
| site_id | PS00242 |
| Number of Residues | 8 |
| Details | INTEGRIN_ALPHA Integrins alpha chain signature. YRmGFFkR |
| Chain | Residue | Details |
| A | TYR1016-ARG1023 |
| site_id | PS00243 |
| Number of Residues | 14 |
| Details | I_EGF_1 Integrins beta chain EGF (I-EGF) domain signature. CsQr..GeClCgqCvC |
| Chain | Residue | Details |
| B | CYS521-CYS534 | |
| B | CYS562-CYS575 | |
| B | CYS601-CYS614 |
| site_id | PS01186 |
| Number of Residues | 14 |
| Details | EGF_2 EGF-like domain signature 2. CrCgpGWlgsqce..C |
| Chain | Residue | Details |
| B | CYS486-CYS499 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 691 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| B | GLY27-ASP718 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| B | ILE719-TRP741 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 46 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| B | LYS742-THR788 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU |
| Chain | Residue | Details |
| B | SER147 | |
| A | ASP322 | |
| A | ASP379 | |
| A | ASP381 | |
| A | ASP383 | |
| A | PHE385 | |
| A | ASP387 | |
| A | ASP443 | |
| A | ASP445 | |
| A | ASN447 | |
| A | TYR449 | |
| B | GLU246 | |
| A | ASP451 | |
| A | ASP264 | |
| A | ILE266 | |
| A | ASP268 | |
| A | ASP314 | |
| A | ASN316 | |
| A | ASP318 | |
| A | TYR320 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCU |
| Chain | Residue | Details |
| B | SER149 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: in ADMIDAS binding site => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASP152 | |
| B | ASP153 | |
| A | ASN488 | |
| A | ASN554 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU |
| Chain | Residue | Details |
| B | ASP184 | |
| B | ASN241 | |
| B | ASP243 | |
| B | PRO245 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: in LIMBS binding site => ECO:0007744|PDB:4G1M |
| Chain | Residue | Details |
| B | ASP277 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | BINDING: in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | MET361 | |
| A | ASN973 | |
| A | ASN980 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O54890 |
| Chain | Residue | Details |
| B | THR767 | |
| A | ASN945 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:19141530, ECO:0007744|PubMed:18088087 |
| Chain | Residue | Details |
| B | TYR773 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PDPK1 and PKB/AKT1; in vitro => ECO:0000269|PubMed:10896934 |
| Chain | Residue | Details |
| B | THR779 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:8631894 |
| Chain | Residue | Details |
| B | TYR785 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN125 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN346 | |
| B | ASN397 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN478 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN585 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19159218, ECO:0007744|PDB:1JV2 |
| Chain | Residue | Details |
| B | ASN680 |
