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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8XER

Cryo-EM structure of integrin ITGAV, ITGB3 and Cilengitide TFA complex, conformation 1

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0007155biological_processcell adhesion
A0008305cellular_componentintegrin complex
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CrCgpGwlGSqC
ChainResidueDetails
BCYS486-CYS497
BCYS573-CYS584
site_idPS00242
Number of Residues8
DetailsINTEGRIN_ALPHA Integrins alpha chain signature. YRmGFFkR
ChainResidueDetails
ATYR1016-ARG1023
site_idPS00243
Number of Residues14
DetailsI_EGF_1 Integrins beta chain EGF (I-EGF) domain signature. CsQr..GeClCgqCvC
ChainResidueDetails
BCYS521-CYS534
BCYS562-CYS575
BCYS601-CYS614
site_idPS01186
Number of Residues14
DetailsEGF_2 EGF-like domain signature 2. CrCgpGWlgsqce..C
ChainResidueDetails
BCYS486-CYS499
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues61
DetailsRepeat: {"description":"FG-GAP 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues52
DetailsRepeat: {"description":"FG-GAP 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues54
DetailsRepeat: {"description":"FG-GAP 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues65
DetailsRepeat: {"description":"FG-GAP 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues57
DetailsRepeat: {"description":"FG-GAP 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues63
DetailsRepeat: {"description":"FG-GAP 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FFG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues46
DetailsDomain: {"description":"PSI","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues242
DetailsDomain: {"description":"VWFA","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues35
DetailsDomain: {"description":"I-EGF 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01392","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues7
DetailsRegion: {"description":"Involved in CX3CL1-, NRG1-, FGF1- and IGF1-binding","evidences":[{"source":"PubMed","id":"18441324","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19578119","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20682778","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23125415","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues20
DetailsRegion: {"description":"CX3CL1-binding","evidences":[{"source":"PubMed","id":"24789099","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsBinding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsBinding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsBinding site: {"description":"in ADMIDAS binding site","evidences":[{"source":"PubMed","id":"11546839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues4
DetailsBinding site: {"description":"in LIMBS binding site","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsBinding site: {"description":"in LIMBS binding site","evidences":[{"source":"PDB","id":"4G1M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues1
DetailsBinding site: {"description":"in ADMIDAS binding site and unliganded-closed conformation","evidences":[{"source":"PubMed","id":"11546839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11546839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2025-10-29

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