8X94
Structure of human TRPV1 in complex with antagonist --protein purified without CHS
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2436 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | MET1-ARG433 | |
C | GLN498-SER510 | |
C | ARG557-LYS571 | |
C | ASN688-LYS839 | |
D | MET1-ARG433 | |
D | GLN498-SER510 | |
D | ARG557-LYS571 | |
D | ASN688-LYS839 | |
A | GLN498-SER510 | |
A | ARG557-LYS571 | |
A | ASN688-LYS839 | |
B | MET1-ARG433 | |
B | GLN498-SER510 | |
B | ARG557-LYS571 | |
B | ASN688-LYS839 | |
C | MET1-ARG433 |
site_id | SWS_FT_FI2 |
Number of Residues | 560 |
Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | ILE434-TYR454 | |
B | GLU536-THR556 | |
B | MET572-ILE599 | |
B | VAL659-VAL687 | |
C | ILE434-TYR454 | |
C | TYR472-LEU497 | |
C | TYR511-PHE531 | |
C | GLU536-THR556 | |
C | MET572-ILE599 | |
C | VAL659-VAL687 | |
D | ILE434-TYR454 | |
A | TYR472-LEU497 | |
D | TYR472-LEU497 | |
D | TYR511-PHE531 | |
D | GLU536-THR556 | |
D | MET572-ILE599 | |
D | VAL659-VAL687 | |
A | TYR511-PHE531 | |
A | GLU536-THR556 | |
A | MET572-ILE599 | |
A | VAL659-VAL687 | |
B | ILE434-TYR454 | |
B | TYR472-LEU497 | |
B | TYR511-PHE531 |
site_id | SWS_FT_FI3 |
Number of Residues | 308 |
Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | TYR455-ASP471 | |
D | TYR455-ASP471 | |
D | SER532-LYS535 | |
D | GLU600-ALA658 | |
A | SER532-LYS535 | |
A | GLU600-ALA658 | |
B | TYR455-ASP471 | |
B | SER532-LYS535 | |
B | GLU600-ALA658 | |
C | TYR455-ASP471 | |
C | SER532-LYS535 | |
C | GLU600-ALA658 |
site_id | SWS_FT_FI4 |
Number of Residues | 36 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | ARG116 | |
B | ARG116 | |
B | LYS156 | |
B | LYS161 | |
B | ASN165 | |
B | TYR200 | |
B | GLU211 | |
B | TYR511 | |
B | THR550 | |
B | ARG557 | |
C | ARG116 | |
A | LYS156 | |
C | LYS156 | |
C | LYS161 | |
C | ASN165 | |
C | TYR200 | |
C | GLU211 | |
C | TYR511 | |
C | THR550 | |
C | ARG557 | |
D | ARG116 | |
D | LYS156 | |
A | LYS161 | |
D | LYS161 | |
D | ASN165 | |
D | TYR200 | |
D | GLU211 | |
D | TYR511 | |
D | THR550 | |
D | ARG557 | |
A | ASN165 | |
A | TYR200 | |
A | GLU211 | |
A | TYR511 | |
A | THR550 | |
A | ARG557 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9R186 |
Chain | Residue | Details |
A | ASP647 | |
B | ASP647 | |
C | ASP647 | |
D | ASP647 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by PKA and PKD => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | SER117 | |
B | SER117 | |
C | SER117 | |
D | SER117 |
site_id | SWS_FT_FI7 |
Number of Residues | 8 |
Details | MOD_RES: Phosphothreonine; by PKA; in vitro => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | THR145 | |
A | THR371 | |
B | THR145 | |
B | THR371 | |
C | THR145 | |
C | THR371 | |
D | THR145 | |
D | THR371 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by PKC/PRKCE => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | SER502 | |
B | SER502 | |
C | SER502 | |
D | SER502 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | THR705 | |
B | THR705 | |
C | THR705 | |
D | THR705 |
site_id | SWS_FT_FI10 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | SER775 | |
A | SER821 | |
B | SER775 | |
B | SER821 | |
C | SER775 | |
C | SER821 | |
D | SER775 | |
D | SER821 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by PKC/PRKCE and PKC/PRKCZ => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | SER801 | |
B | SER801 | |
C | SER801 | |
D | SER801 |
site_id | SWS_FT_FI12 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | ASN604 | |
B | ASN604 | |
C | ASN604 | |
D | ASN604 |