8X93
P/Q type calcium channel in complex with omega-Agatoxin IVA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001540 | molecular_function | amyloid-beta binding |
| A | 0005245 | molecular_function | voltage-gated calcium channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005891 | cellular_component | voltage-gated calcium channel complex |
| A | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0008331 | molecular_function | high voltage-gated calcium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019905 | molecular_function | syntaxin binding |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0042995 | cellular_component | cell projection |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050804 | biological_process | modulation of chemical synaptic transmission |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0098703 | biological_process | calcium ion import across plasma membrane |
| A | 1904645 | biological_process | response to amyloid-beta |
| A | 1904646 | biological_process | cellular response to amyloid-beta |
| C | 0005245 | molecular_function | voltage-gated calcium channel activity |
| C | 0005246 | molecular_function | calcium channel regulator activity |
| C | 0005262 | molecular_function | calcium channel activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005891 | cellular_component | voltage-gated calcium channel complex |
| C | 0006816 | biological_process | calcium ion transport |
| C | 0007268 | biological_process | chemical synaptic transmission |
| C | 0007528 | biological_process | neuromuscular junction development |
| C | 0008331 | molecular_function | high voltage-gated calcium channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0034702 | cellular_component | monoatomic ion channel complex |
| C | 0045202 | cellular_component | synapse |
| C | 0050852 | biological_process | T cell receptor signaling pathway |
| C | 0060402 | biological_process | calcium ion transport into cytosol |
| C | 0061577 | biological_process | calcium ion transmembrane transport via high voltage-gated calcium channel |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0072659 | biological_process | protein localization to plasma membrane |
| C | 0098903 | biological_process | regulation of membrane repolarization during action potential |
| C | 1901843 | biological_process | positive regulation of high voltage-gated calcium channel activity |
| C | 1990454 | cellular_component | L-type voltage-gated calcium channel complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1610 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-PRO98 | |
| A | ILE1509-VAL1563 | |
| A | ALA1618-PHE1625 | |
| A | LEU1671-LYS1689 | |
| A | ALA1807-CYS2506 | |
| A | GLY156-ASN167 | |
| A | PRO210-GLN228 | |
| A | GLY361-GLN486 | |
| A | GLY541-SER548 | |
| A | ALA597-SER615 | |
| A | ASP714-ASN1241 | |
| A | ASP1297-PHE1308 | |
| A | ARG1358-VAL1376 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO99-LEU117 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 374 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU118-ASP135 | |
| A | TYR1593-LEU1597 | |
| A | LEU1645-ASN1651 | |
| A | MET1710-CYS1781 | |
| A | GLY186-ASP190 | |
| A | MET249-TRP335 | |
| A | VAL506-TYR520 | |
| A | ALA568-GLY577 | |
| A | GLY636-VAL688 | |
| A | ALA1261-LEU1276 | |
| A | ALA1328-ILE1338 | |
| A | LEU1397-ARG1483 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | THR136-LEU155 | |
| B | SER261 | |
| B | SER263 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY168-VAL185 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU191-ILE209 | |
| B | ASN184 | |
| B | ASN348 | |
| B | ASN468 | |
| B | ASN613 | |
| B | ASN781 | |
| B | ASN895 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE229-TYR248 | |
| B | ASN324 | |
| B | ASN475 | |
| B | ASN604 | |
| B | ASN675 | |
| B | ASN824 | |
| B | ASN888 | |
| B | ASN985 | |
| B | ASN998 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN336-SER360 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA487-ILE505 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA521-LEU540 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | SER549-TRP567 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE578-TRP596 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU616-PHE635 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE689-VAL713 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU1242-LEU1260 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG1277-ILE1296 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG1309-PHE1327 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN1339-LYS1357 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE1377-GLN1396 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1484-LEU1508 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | SER1564-ALA1592 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG1598-MET1617 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG1626-ILE1644 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN1652-LEU1670 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA1690-GLY1709 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY1782-VAL1806 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P07293 |
| Chain | Residue | Details |
| A | GLU318 | |
| A | GLU667 | |
| A | GLU1459 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 1 |
| Details | SITE: Binds to omega-Aga-IVA => ECO:0000250|UniProtKB:P27884 |
| Chain | Residue | Details |
| A | GLU1648 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P97445 |
| Chain | Residue | Details |
| A | THR409 | |
| A | THR1983 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97445 |
| Chain | Residue | Details |
| A | SER447 | |
| A | SER450 | |
| A | SER749 | |
| A | SER752 | |
| A | SER789 | |
| A | SER1084 | |
| A | SER1093 | |
| A | SER2064 | |
| A | SER2119 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P54282 |
| Chain | Residue | Details |
| A | SER2046 | |
| A | SER2076 | |
| A | SER2078 | |
| A | SER2139 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN283 |
