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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8X83

The cryo-EM structure of insect gustatory receptor Gr43a I418A from Drosophila melanogaster in complex with fructose

Functional Information from GO Data
ChainGOidnamespacecontents
A0001582biological_processdetection of chemical stimulus involved in sensory perception of sweet taste
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007635biological_processchemosensory behavior
A0008049biological_processmale courtship behavior
A0008343biological_processadult feeding behavior
A0008527molecular_functiontaste receptor activity
A0016020cellular_componentmembrane
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0032098biological_processregulation of appetite
A0033041molecular_functionsweet taste receptor activity
A0043025cellular_componentneuronal cell body
A0050909biological_processsensory perception of taste
A0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
A0050916biological_processsensory perception of sweet taste
A0060259biological_processregulation of feeding behavior
A0071332biological_processcellular response to fructose stimulus
A0098655biological_processmonoatomic cation transmembrane transport
A0099094molecular_functionligand-gated monoatomic cation channel activity
A0170023molecular_functionionotropic sweet taste receptor activity
B0001582biological_processdetection of chemical stimulus involved in sensory perception of sweet taste
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007635biological_processchemosensory behavior
B0008049biological_processmale courtship behavior
B0008343biological_processadult feeding behavior
B0008527molecular_functiontaste receptor activity
B0016020cellular_componentmembrane
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0032098biological_processregulation of appetite
B0033041molecular_functionsweet taste receptor activity
B0043025cellular_componentneuronal cell body
B0050909biological_processsensory perception of taste
B0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
B0050916biological_processsensory perception of sweet taste
B0060259biological_processregulation of feeding behavior
B0071332biological_processcellular response to fructose stimulus
B0098655biological_processmonoatomic cation transmembrane transport
B0099094molecular_functionligand-gated monoatomic cation channel activity
B0170023molecular_functionionotropic sweet taste receptor activity
C0001582biological_processdetection of chemical stimulus involved in sensory perception of sweet taste
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007635biological_processchemosensory behavior
C0008049biological_processmale courtship behavior
C0008343biological_processadult feeding behavior
C0008527molecular_functiontaste receptor activity
C0016020cellular_componentmembrane
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0032098biological_processregulation of appetite
C0033041molecular_functionsweet taste receptor activity
C0043025cellular_componentneuronal cell body
C0050909biological_processsensory perception of taste
C0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
C0050916biological_processsensory perception of sweet taste
C0060259biological_processregulation of feeding behavior
C0071332biological_processcellular response to fructose stimulus
C0098655biological_processmonoatomic cation transmembrane transport
C0099094molecular_functionligand-gated monoatomic cation channel activity
C0170023molecular_functionionotropic sweet taste receptor activity
D0001582biological_processdetection of chemical stimulus involved in sensory perception of sweet taste
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007635biological_processchemosensory behavior
D0008049biological_processmale courtship behavior
D0008343biological_processadult feeding behavior
D0008527molecular_functiontaste receptor activity
D0016020cellular_componentmembrane
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0032098biological_processregulation of appetite
D0033041molecular_functionsweet taste receptor activity
D0043025cellular_componentneuronal cell body
D0050909biological_processsensory perception of taste
D0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
D0050916biological_processsensory perception of sweet taste
D0060259biological_processregulation of feeding behavior
D0071332biological_processcellular response to fructose stimulus
D0098655biological_processmonoatomic cation transmembrane transport
D0099094molecular_functionligand-gated monoatomic cation channel activity
D0170023molecular_functionionotropic sweet taste receptor activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues516
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"38305684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JM9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues100
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"38305684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JM9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues108
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"38305684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JM9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"38305684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JM9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"38305684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JM9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"38305684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JM9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"38305684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JM9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"38305684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JM9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=S7b","evidences":[{"source":"PubMed","id":"38305684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JM9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38305684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JMA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X83","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38305684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8X84","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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