8X5K
The Crystal Structure of SYK from Biortus.
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 26 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGNFGTVKkGyyqmkkvvkt........VAVK |
| Chain | Residue | Details |
| A | LEU377-LYS402 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNVLL |
| Chain | Residue | Details |
| A | PHE490-LEU502 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 |
| Chain | Residue | Details |
| A | ASP494 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LEU377 | |
| A | LYS402 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:21469132 |
| Chain | Residue | Details |
| A | TYR364 | |
| A | TYR484 | |
| A | TYR507 | |
| A | TYR526 | |
| A | TYR629 | |
| A | TYR631 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:21469132 |
| Chain | Residue | Details |
| A | SER379 | |
| A | SER579 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:21469132 |
| Chain | Residue | Details |
| A | THR384 | |
| A | THR530 | |
| A | THR582 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:21469132 |
| Chain | Residue | Details |
| A | TYR525 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P48025 |
| Chain | Residue | Details |
| A | TYR546 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:18369315, ECO:0000269|PubMed:21469132 |
| Chain | Residue | Details |
| A | TYR630 |
