8X3E

CYP725A4-Taxa-4,11-diene complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGgGQRSCVG

Chain	Residue	Details
A	PHE406-GLY415

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2024","firstPage":"3912","lastPage":"3925","volume":"14","journal":"ACS Catal.","title":"Unraveling the catalytic mechanism of taxadiene-5alpha-hydroxylase from crystallography and computational analyses.","authors":["Song X.","Wang Q.","Zhu X.","Fang W.","Liu X.","Shi C.","Chang Z.","Jiang H.","Wang B."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.3c05807"}]}},{"source":"PDB","id":"8X1W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2024","firstPage":"3912","lastPage":"3925","volume":"14","journal":"ACS Catal.","title":"Unraveling the catalytic mechanism of taxadiene-5alpha-hydroxylase from crystallography and computational analyses.","authors":["Song X.","Wang Q.","Zhu X.","Fang W.","Liu X.","Shi C.","Chang Z.","Jiang H.","Wang B."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.3c05807"}]}},{"source":"PDB","id":"8X1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X3E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2024","firstPage":"3912","lastPage":"3925","volume":"14","journal":"ACS Catal.","title":"Unraveling the catalytic mechanism of taxadiene-5alpha-hydroxylase from crystallography and computational analyses.","authors":["Song X.","Wang Q.","Zhu X.","Fang W.","Liu X.","Shi C.","Chang Z.","Jiang H.","Wang B."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.3c05807"}]}},{"source":"PDB","id":"8X1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X3E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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