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8X2K

a lipid receptor complex structure

Functional Information from GO Data
ChainGOidnamespacecontents
A0004930molecular_functionG protein-coupled receptor activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0019222biological_processregulation of metabolic process
A0040020biological_processregulation of meiotic nuclear division
A0042597cellular_componentperiplasmic space
A0043950biological_processpositive regulation of cAMP-mediated signaling
A0046872molecular_functionmetal ion binding
A0051480biological_processregulation of cytosolic calcium ion concentration
A0120162biological_processpositive regulation of cold-induced thermogenesis
B0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
B0003091biological_processrenal water homeostasis
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0007190biological_processactivation of adenylate cyclase activity
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007608biological_processsensory perception of smell
B0010856molecular_functionadenylate cyclase activator activity
B0016020cellular_componentmembrane
B0031748molecular_functionD1 dopamine receptor binding
B0032588cellular_componenttrans-Golgi network membrane
B0046872molecular_functionmetal ion binding
B0046907biological_processintracellular transport
B0048589biological_processdevelopmental growth
B0050796biological_processregulation of insulin secretion
B0050890biological_processcognition
B0060348biological_processbone development
B0060789biological_processhair follicle placode formation
B0070062cellular_componentextracellular exosome
B0070527biological_processplatelet aggregation
B0071377biological_processcellular response to glucagon stimulus
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
B0120162biological_processpositive regulation of cold-induced thermogenesis
C0001750cellular_componentphotoreceptor outer segment
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
C0007265biological_processRas protein signal transduction
C0008283biological_processcell population proliferation
C0016020cellular_componentmembrane
C0030159molecular_functionsignaling receptor complex adaptor activity
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0050909biological_processsensory perception of taste
C0051020molecular_functionGTPase binding
C0060041biological_processretina development in camera-type eye
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
C0097381cellular_componentphotoreceptor disc membrane
C1903561cellular_componentextracellular vesicle
D0005515molecular_functionprotein binding
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
D0016020cellular_componentmembrane
D0031681molecular_functionG-protein beta-subunit binding
D0048144biological_processfibroblast proliferation
D0070062cellular_componentextracellular exosome
D0071380biological_processcellular response to prostaglandin E stimulus
D0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIgSLLAITVDRYLsL
ChainResidueDetails
AALA122-LEU138

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
CLEU70-SER84
CILE157-ILE171
CLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues7
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P04896
ChainResidueDetails
BGLY47
BSER54
BLYS211
BASN218
BCYS237
BSER306
BARG380

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250
ChainResidueDetails
BASP215
AALA99-LEU110
AALA174-LEU198
AHIS273-LEU277

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
BALA366

site_idSWS_FT_FI4
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
BGLU314
AASP133-THR153
AARG218-GLY245
AARG300-VAL330

site_idSWS_FT_FI5
Number of Residues23
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
AMET75-ALA98

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
AVAL111-VAL132

site_idSWS_FT_FI7
Number of Residues19
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
ATYR154-LEU173

site_idSWS_FT_FI8
Number of Residues18
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
AALA199-CYS217

site_idSWS_FT_FI9
Number of Residues26
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
AILE246-ALA272

site_idSWS_FT_FI10
Number of Residues21
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
ATYR278-PHE299

site_idSWS_FT_FI11
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0000255
ChainResidueDetails
ASER324
ASER326
ASER328

site_idSWS_FT_FI12
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
ACYS313

site_idSWS_FT_FI13
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN20

222926

PDB entries from 2024-07-24

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