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8WX4

Cryo-EM structure of human SLC15A4 in complex with Lys-Leu (outward-facing open)

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0005290molecular_functionL-histidine transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005765cellular_componentlysosomal membrane
A0005886cellular_componentplasma membrane
A0006857biological_processoligopeptide transport
A0010008cellular_componentendosome membrane
A0015031biological_processprotein transport
A0015293molecular_functionsymporter activity
A0015333molecular_functionpeptide:proton symporter activity
A0015647molecular_functionpeptidoglycan transmembrane transporter activity
A0015817biological_processhistidine transport
A0015833biological_processpeptide transport
A0015835biological_processpeptidoglycan transport
A0016020cellular_componentmembrane
A0022857molecular_functiontransmembrane transporter activity
A0031901cellular_componentearly endosome membrane
A0033023biological_processmast cell homeostasis
A0034157biological_processpositive regulation of toll-like receptor 7 signaling pathway
A0034161biological_processpositive regulation of toll-like receptor 8 signaling pathway
A0034165biological_processpositive regulation of toll-like receptor 9 signaling pathway
A0035579cellular_componentspecific granule membrane
A0035672biological_processoligopeptide transmembrane transport
A0036020cellular_componentendolysosome membrane
A0045087biological_processinnate immune response
A0045089biological_processpositive regulation of innate immune response
A0048302biological_processregulation of isotype switching to IgG isotypes
A0055085biological_processtransmembrane transport
A0070424biological_processregulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
A0070430biological_processpositive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
A0070434biological_processpositive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
A0071916molecular_functiondipeptide transmembrane transporter activity
A0089708biological_processL-histidine transmembrane export from vacuole
A0140206biological_processdipeptide import across plasma membrane
A1902600biological_processproton transmembrane transport
B0002376biological_processimmune system process
B0005290molecular_functionL-histidine transmembrane transporter activity
B0005515molecular_functionprotein binding
B0005765cellular_componentlysosomal membrane
B0005886cellular_componentplasma membrane
B0006857biological_processoligopeptide transport
B0010008cellular_componentendosome membrane
B0015031biological_processprotein transport
B0015293molecular_functionsymporter activity
B0015333molecular_functionpeptide:proton symporter activity
B0015647molecular_functionpeptidoglycan transmembrane transporter activity
B0015817biological_processhistidine transport
B0015833biological_processpeptide transport
B0015835biological_processpeptidoglycan transport
B0016020cellular_componentmembrane
B0022857molecular_functiontransmembrane transporter activity
B0031901cellular_componentearly endosome membrane
B0033023biological_processmast cell homeostasis
B0034157biological_processpositive regulation of toll-like receptor 7 signaling pathway
B0034161biological_processpositive regulation of toll-like receptor 8 signaling pathway
B0034165biological_processpositive regulation of toll-like receptor 9 signaling pathway
B0035579cellular_componentspecific granule membrane
B0035672biological_processoligopeptide transmembrane transport
B0036020cellular_componentendolysosome membrane
B0045087biological_processinnate immune response
B0045089biological_processpositive regulation of innate immune response
B0048302biological_processregulation of isotype switching to IgG isotypes
B0055085biological_processtransmembrane transport
B0070424biological_processregulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
B0070430biological_processpositive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
B0070434biological_processpositive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
B0071916molecular_functiondipeptide transmembrane transporter activity
B0089708biological_processL-histidine transmembrane export from vacuole
B0140206biological_processdipeptide import across plasma membrane
B1902600biological_processproton transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00079
Number of Residues21
DetailsMULTICOPPER_OXIDASE1 Multicopper oxidases signature 1. GlFfFfSgVGsfVgSGLlalV
ChainResidueDetails
BGLY490-VAL510

site_idPS01023
Number of Residues13
DetailsPTR2_2 PTR2 family proton/oligopeptide symporters signature 2. FnwFYWsINLGAI
ChainResidueDetails
BPHE195-ILE207

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues480
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246905

PDB entries from 2025-12-31

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