8WVG
Human VMAT2 in complex with tetrabenazine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001975 | biological_process | response to amphetamine |
| A | 0002552 | biological_process | serotonin secretion by mast cell |
| A | 0002553 | biological_process | histamine secretion by mast cell |
| A | 0005335 | molecular_function | serotonin:sodium:chloride symporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005813 | cellular_component | centrosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006836 | biological_process | neurotransmitter transport |
| A | 0006837 | biological_process | serotonin transport |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0007626 | biological_process | locomotory behavior |
| A | 0008021 | cellular_component | synaptic vesicle |
| A | 0008504 | molecular_function | monoamine transmembrane transporter activity |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0009791 | biological_process | post-embryonic development |
| A | 0015311 | molecular_function | monoamine:proton antiporter activity |
| A | 0015842 | biological_process | aminergic neurotransmitter loading into synaptic vesicle |
| A | 0015844 | biological_process | monoamine transport |
| A | 0015872 | biological_process | dopamine transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030424 | cellular_component | axon |
| A | 0030425 | cellular_component | dendrite |
| A | 0030658 | cellular_component | transport vesicle membrane |
| A | 0030667 | cellular_component | secretory granule membrane |
| A | 0030672 | cellular_component | synaptic vesicle membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0042995 | cellular_component | cell projection |
| A | 0043195 | cellular_component | terminal bouton |
| A | 0045202 | cellular_component | synapse |
| A | 0051610 | biological_process | serotonin uptake |
| A | 0051615 | biological_process | histamine uptake |
| A | 0051649 | biological_process | establishment of localization in cell |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070083 | cellular_component | clathrin-sculpted monoamine transport vesicle membrane |
| A | 0098691 | cellular_component | dopaminergic synapse |
| A | 0098700 | biological_process | neurotransmitter loading into synaptic vesicle |
| A | 0099123 | biological_process | somato-dendritic dopamine secretion |
| A | 1902600 | biological_process | proton transmembrane transport |
| A | 1903427 | biological_process | negative regulation of reactive oxygen species biosynthetic process |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 112 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0000269|PubMed:38517752, ECO:0007744|PDB:8JSW, ECO:0007744|PDB:8JT9, ECO:0007744|PDB:8JTA, ECO:0007744|PDB:8JTC, ECO:0007744|PDB:8T69, ECO:0007744|PDB:8T6A, ECO:0007744|PDB:8T6B, ECO:0007744|PDB:8THR |
| Chain | Residue | Details |
| A | MET1-LYS20 | |
| A | LEU151-PRO159 | |
| A | TYR211-ASN219 | |
| A | PRO272-ASP291 | |
| A | HIS353-ARG357 | |
| A | ASP411-HIS414 | |
| A | PHE463-ASP514 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0000269|PubMed:38517752, ECO:0007744|PDB:8JSW, ECO:0007744|PDB:8JT9, ECO:0007744|PDB:8JTA, ECO:0007744|PDB:8JTC, ECO:0007744|PDB:8T69, ECO:0007744|PDB:8T6A, ECO:0007744|PDB:8T6B, ECO:0007744|PDB:8THR |
| Chain | Residue | Details |
| A | LEU21-VAL41 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 130 |
| Details | TOPO_DOM: Lumenal, vesicle => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0000269|PubMed:38517752, ECO:0007744|PDB:8JSW, ECO:0007744|PDB:8JT9, ECO:0007744|PDB:8JTA, ECO:0007744|PDB:8JTC, ECO:0007744|PDB:8T69, ECO:0007744|PDB:8T6A, ECO:0007744|PDB:8T6B, ECO:0007744|PDB:8THR |
| Chain | Residue | Details |
| A | PRO42-VAL129 | |
| A | SER181-ARG189 | |
| A | TYR243-LYS248 | |
| A | GLU312-TRP328 | |
| A | LYS379-PHE389 | |
| A | GLY436-GLY440 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0000269|PubMed:38517752, ECO:0007744|PDB:8JSW, ECO:0007744|PDB:8JT9, ECO:0007744|PDB:8JTA, ECO:0007744|PDB:8JTC, ECO:0007744|PDB:8T69, ECO:0007744|PDB:8T6A, ECO:0007744|PDB:8T6B, ECO:0007744|PDB:8THR |
| Chain | Residue | Details |
| A | GLN130-GLY150 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0000269|PubMed:38517752, ECO:0007744|PDB:8JSW, ECO:0007744|PDB:8JT9, ECO:0007744|PDB:8JTA, ECO:0007744|PDB:8JTC, ECO:0007744|PDB:8T69, ECO:0007744|PDB:8T6A, ECO:0007744|PDB:8T6B, ECO:0007744|PDB:8THR |
| Chain | Residue | Details |
| A | ILE160-SER180 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0000269|PubMed:38517752, ECO:0007744|PDB:8JSW, ECO:0007744|PDB:8JT9, ECO:0007744|PDB:8JTA, ECO:0007744|PDB:8JTC, ECO:0007744|PDB:8T69, ECO:0007744|PDB:8T6A, ECO:0007744|PDB:8T6B, ECO:0007744|PDB:8THR |
| Chain | Residue | Details |
| A | SER190-VAL210 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0000269|PubMed:38517752, ECO:0007744|PDB:8JSW, ECO:0007744|PDB:8JT9, ECO:0007744|PDB:8JTA, ECO:0007744|PDB:8JTC, ECO:0007744|PDB:8T69, ECO:0007744|PDB:8T6A, ECO:0007744|PDB:8T6B, ECO:0007744|PDB:8THR |
| Chain | Residue | Details |
| A | VAL220-LEU242 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0000269|PubMed:38517752, ECO:0007744|PDB:8JSW, ECO:0007744|PDB:8JT9, ECO:0007744|PDB:8JTA, ECO:0007744|PDB:8JTC, ECO:0007744|PDB:8T69, ECO:0007744|PDB:8T6A, ECO:0007744|PDB:8T6B, ECO:0007744|PDB:8THR |
| Chain | Residue | Details |
| A | THR249-GLN271 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0000269|PubMed:38517752, ECO:0007744|PDB:8JSW, ECO:0007744|PDB:8JT9, ECO:0007744|PDB:8JTA, ECO:0007744|PDB:8JTC, ECO:0007744|PDB:8T69, ECO:0007744|PDB:8T6A, ECO:0007744|PDB:8T6B, ECO:0007744|PDB:8THR |
| Chain | Residue | Details |
| A | PRO292-LEU311 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0000269|PubMed:38517752, ECO:0007744|PDB:8JSW, ECO:0007744|PDB:8JT9, ECO:0007744|PDB:8JTA, ECO:0007744|PDB:8JTC, ECO:0007744|PDB:8T69, ECO:0007744|PDB:8T6A, ECO:0007744|PDB:8T6B, ECO:0007744|PDB:8THR |
| Chain | Residue | Details |
| A | GLN329-ALA352 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0000269|PubMed:38517752, ECO:0007744|PDB:8JSW, ECO:0007744|PDB:8JT9, ECO:0007744|PDB:8JTA, ECO:0007744|PDB:8JTC, ECO:0007744|PDB:8T69, ECO:0007744|PDB:8T6A, ECO:0007744|PDB:8T6B, ECO:0007744|PDB:8THR |
| Chain | Residue | Details |
| A | TRP358-ALA378 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0000269|PubMed:38517752, ECO:0007744|PDB:8JSW, ECO:0007744|PDB:8JT9, ECO:0007744|PDB:8JTA, ECO:0007744|PDB:8JTC, ECO:0007744|PDB:8T69, ECO:0007744|PDB:8T6A, ECO:0007744|PDB:8T6B, ECO:0007744|PDB:8THR |
| Chain | Residue | Details |
| A | GLY390-VAL410 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0000269|PubMed:38517752, ECO:0007744|PDB:8JSW, ECO:0007744|PDB:8JT9, ECO:0007744|PDB:8JTA, ECO:0007744|PDB:8JTC, ECO:0007744|PDB:8T69, ECO:0007744|PDB:8T6A, ECO:0007744|PDB:8T6B, ECO:0007744|PDB:8THR |
| Chain | Residue | Details |
| A | VAL415-ILE435 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0000269|PubMed:38517752, ECO:0007744|PDB:8JSW, ECO:0007744|PDB:8JT9, ECO:0007744|PDB:8JTA, ECO:0007744|PDB:8JTC, ECO:0007744|PDB:8T69, ECO:0007744|PDB:8T6A, ECO:0007744|PDB:8T6B, ECO:0007744|PDB:8THR |
| Chain | Residue | Details |
| A | GLY441-LEU462 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38081299 |
| Chain | Residue | Details |
| A | LEU228 | |
| A | TYR341 | |
| A | ASP399 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299 |
| Chain | Residue | Details |
| A | VAL232 | |
| A | ILE308 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38081299, ECO:0007744|PDB:8JSW |
| Chain | Residue | Details |
| A | ASN305 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0007744|PDB:8JSW, ECO:0007744|PDB:8T6B |
| Chain | Residue | Details |
| A | GLU312 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37914936, ECO:0000269|PubMed:38081299, ECO:0007744|PDB:8T6B |
| Chain | Residue | Details |
| A | PHE334 | |
| A | TYR433 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q01827 |
| Chain | Residue | Details |
| A | SER511 | |
| A | SER513 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN84 | |
| A | ASN91 |
