8WUL

Crystal structure of affinity enhanced TCR in complex with HLA-A*11:01 bound to KRAS-G12V peptide (VVGAVGVGK)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002439	biological_process	chronic inflammatory response to antigenic stimulus
A	0005575	cellular_component	cellular_component
A	0010038	biological_process	response to metal ion
A	0042605	molecular_function	peptide antigen binding
A	0050852	biological_process	T cell receptor signaling pathway
C	0002439	biological_process	chronic inflammatory response to antigenic stimulus
C	0005575	cellular_component	cellular_component
C	0010038	biological_process	response to metal ion
C	0042605	molecular_function	peptide antigen binding
C	0050852	biological_process	T cell receptor signaling pathway
E	0002439	biological_process	chronic inflammatory response to antigenic stimulus
E	0005575	cellular_component	cellular_component
E	0010038	biological_process	response to metal ion
E	0042605	molecular_function	peptide antigen binding
E	0050852	biological_process	T cell receptor signaling pathway
G	0002439	biological_process	chronic inflammatory response to antigenic stimulus
G	0005575	cellular_component	cellular_component
G	0010038	biological_process	response to metal ion
G	0042605	molecular_function	peptide antigen binding
G	0050852	biological_process	T cell receptor signaling pathway
J	0000139	cellular_component	Golgi membrane
J	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
J	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
J	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
J	0002715	biological_process	regulation of natural killer cell mediated immunity
J	0002726	biological_process	positive regulation of T cell cytokine production
J	0005198	molecular_function	structural molecule activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005765	cellular_component	lysosomal membrane
J	0005783	cellular_component	endoplasmic reticulum
J	0005788	cellular_component	endoplasmic reticulum lumen
J	0005794	cellular_component	Golgi apparatus
J	0005886	cellular_component	plasma membrane
J	0005925	cellular_component	focal adhesion
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006955	biological_process	immune response
J	0007608	biological_process	sensory perception of smell
J	0007611	biological_process	learning or memory
J	0009897	cellular_component	external side of plasma membrane
J	0009986	cellular_component	cell surface
J	0010038	biological_process	response to metal ion
J	0012507	cellular_component	ER to Golgi transport vesicle membrane
J	0016020	cellular_component	membrane
J	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
J	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
J	0023026	molecular_function	MHC class II protein complex binding
J	0030670	cellular_component	phagocytic vesicle membrane
J	0031901	cellular_component	early endosome membrane
J	0031902	cellular_component	late endosome membrane
J	0031905	cellular_component	early endosome lumen
J	0033572	biological_process	transferrin transport
J	0034756	biological_process	regulation of iron ion transport
J	0034757	biological_process	negative regulation of iron ion transport
J	0035580	cellular_component	specific granule lumen
J	0042605	molecular_function	peptide antigen binding
J	0042612	cellular_component	MHC class I protein complex
J	0042613	cellular_component	MHC class II protein complex
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0042824	cellular_component	MHC class I peptide loading complex
J	0048260	biological_process	positive regulation of receptor-mediated endocytosis
J	0048261	biological_process	negative regulation of receptor-mediated endocytosis
J	0050680	biological_process	negative regulation of epithelial cell proliferation
J	0050768	biological_process	negative regulation of neurogenesis
J	0050778	biological_process	positive regulation of immune response
J	0050870	biological_process	positive regulation of T cell activation
J	0051289	biological_process	protein homotetramerization
J	0055038	cellular_component	recycling endosome membrane
J	0070062	cellular_component	extracellular exosome
J	0071281	biological_process	cellular response to iron ion
J	0071316	biological_process	cellular response to nicotine
J	1904724	cellular_component	tertiary granule lumen
J	1990000	biological_process	amyloid fibril formation
J	1990712	cellular_component	HFE-transferrin receptor complex
J	2000774	biological_process	positive regulation of cellular senescence
J	2000978	biological_process	negative regulation of forebrain neuron differentiation
M	0000139	cellular_component	Golgi membrane
M	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
M	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
M	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
M	0002715	biological_process	regulation of natural killer cell mediated immunity
M	0002726	biological_process	positive regulation of T cell cytokine production
M	0005198	molecular_function	structural molecule activity
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005765	cellular_component	lysosomal membrane
M	0005783	cellular_component	endoplasmic reticulum
M	0005788	cellular_component	endoplasmic reticulum lumen
M	0005794	cellular_component	Golgi apparatus
M	0005886	cellular_component	plasma membrane
M	0005925	cellular_component	focal adhesion
M	0006879	biological_process	intracellular iron ion homeostasis
M	0006955	biological_process	immune response
M	0007608	biological_process	sensory perception of smell
M	0007611	biological_process	learning or memory
M	0009897	cellular_component	external side of plasma membrane
M	0009986	cellular_component	cell surface
M	0010038	biological_process	response to metal ion
M	0012507	cellular_component	ER to Golgi transport vesicle membrane
M	0016020	cellular_component	membrane
M	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
M	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
M	0023026	molecular_function	MHC class II protein complex binding
M	0030670	cellular_component	phagocytic vesicle membrane
M	0031901	cellular_component	early endosome membrane
M	0031902	cellular_component	late endosome membrane
M	0031905	cellular_component	early endosome lumen
M	0033572	biological_process	transferrin transport
M	0034756	biological_process	regulation of iron ion transport
M	0034757	biological_process	negative regulation of iron ion transport
M	0035580	cellular_component	specific granule lumen
M	0042605	molecular_function	peptide antigen binding
M	0042612	cellular_component	MHC class I protein complex
M	0042613	cellular_component	MHC class II protein complex
M	0042802	molecular_function	identical protein binding
M	0042803	molecular_function	protein homodimerization activity
M	0042824	cellular_component	MHC class I peptide loading complex
M	0048260	biological_process	positive regulation of receptor-mediated endocytosis
M	0048261	biological_process	negative regulation of receptor-mediated endocytosis
M	0050680	biological_process	negative regulation of epithelial cell proliferation
M	0050768	biological_process	negative regulation of neurogenesis
M	0050778	biological_process	positive regulation of immune response
M	0050870	biological_process	positive regulation of T cell activation
M	0051289	biological_process	protein homotetramerization
M	0055038	cellular_component	recycling endosome membrane
M	0070062	cellular_component	extracellular exosome
M	0071281	biological_process	cellular response to iron ion
M	0071316	biological_process	cellular response to nicotine
M	1904724	cellular_component	tertiary granule lumen
M	1990000	biological_process	amyloid fibril formation
M	1990712	cellular_component	HFE-transferrin receptor complex
M	2000774	biological_process	positive regulation of cellular senescence
M	2000978	biological_process	negative regulation of forebrain neuron differentiation
P	0000139	cellular_component	Golgi membrane
P	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
P	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
P	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
P	0002715	biological_process	regulation of natural killer cell mediated immunity
P	0002726	biological_process	positive regulation of T cell cytokine production
P	0005198	molecular_function	structural molecule activity
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005765	cellular_component	lysosomal membrane
P	0005783	cellular_component	endoplasmic reticulum
P	0005788	cellular_component	endoplasmic reticulum lumen
P	0005794	cellular_component	Golgi apparatus
P	0005886	cellular_component	plasma membrane
P	0005925	cellular_component	focal adhesion
P	0006879	biological_process	intracellular iron ion homeostasis
P	0006955	biological_process	immune response
P	0007608	biological_process	sensory perception of smell
P	0007611	biological_process	learning or memory
P	0009897	cellular_component	external side of plasma membrane
P	0009986	cellular_component	cell surface
P	0010038	biological_process	response to metal ion
P	0012507	cellular_component	ER to Golgi transport vesicle membrane
P	0016020	cellular_component	membrane
P	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
P	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
P	0023026	molecular_function	MHC class II protein complex binding
P	0030670	cellular_component	phagocytic vesicle membrane
P	0031901	cellular_component	early endosome membrane
P	0031902	cellular_component	late endosome membrane
P	0031905	cellular_component	early endosome lumen
P	0033572	biological_process	transferrin transport
P	0034756	biological_process	regulation of iron ion transport
P	0034757	biological_process	negative regulation of iron ion transport
P	0035580	cellular_component	specific granule lumen
P	0042605	molecular_function	peptide antigen binding
P	0042612	cellular_component	MHC class I protein complex
P	0042613	cellular_component	MHC class II protein complex
P	0042802	molecular_function	identical protein binding
P	0042803	molecular_function	protein homodimerization activity
P	0042824	cellular_component	MHC class I peptide loading complex
P	0048260	biological_process	positive regulation of receptor-mediated endocytosis
P	0048261	biological_process	negative regulation of receptor-mediated endocytosis
P	0050680	biological_process	negative regulation of epithelial cell proliferation
P	0050768	biological_process	negative regulation of neurogenesis
P	0050778	biological_process	positive regulation of immune response
P	0050870	biological_process	positive regulation of T cell activation
P	0051289	biological_process	protein homotetramerization
P	0055038	cellular_component	recycling endosome membrane
P	0070062	cellular_component	extracellular exosome
P	0071281	biological_process	cellular response to iron ion
P	0071316	biological_process	cellular response to nicotine
P	1904724	cellular_component	tertiary granule lumen
P	1990000	biological_process	amyloid fibril formation
P	1990712	cellular_component	HFE-transferrin receptor complex
P	2000774	biological_process	positive regulation of cellular senescence
P	2000978	biological_process	negative regulation of forebrain neuron differentiation
S	0000139	cellular_component	Golgi membrane
S	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
S	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
S	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
S	0002715	biological_process	regulation of natural killer cell mediated immunity
S	0002726	biological_process	positive regulation of T cell cytokine production
S	0005198	molecular_function	structural molecule activity
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005765	cellular_component	lysosomal membrane
S	0005783	cellular_component	endoplasmic reticulum
S	0005788	cellular_component	endoplasmic reticulum lumen
S	0005794	cellular_component	Golgi apparatus
S	0005886	cellular_component	plasma membrane
S	0005925	cellular_component	focal adhesion
S	0006879	biological_process	intracellular iron ion homeostasis
S	0006955	biological_process	immune response
S	0007608	biological_process	sensory perception of smell
S	0007611	biological_process	learning or memory
S	0009897	cellular_component	external side of plasma membrane
S	0009986	cellular_component	cell surface
S	0010038	biological_process	response to metal ion
S	0012507	cellular_component	ER to Golgi transport vesicle membrane
S	0016020	cellular_component	membrane
S	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
S	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
S	0023026	molecular_function	MHC class II protein complex binding
S	0030670	cellular_component	phagocytic vesicle membrane
S	0031901	cellular_component	early endosome membrane
S	0031902	cellular_component	late endosome membrane
S	0031905	cellular_component	early endosome lumen
S	0033572	biological_process	transferrin transport
S	0034756	biological_process	regulation of iron ion transport
S	0034757	biological_process	negative regulation of iron ion transport
S	0035580	cellular_component	specific granule lumen
S	0042605	molecular_function	peptide antigen binding
S	0042612	cellular_component	MHC class I protein complex
S	0042613	cellular_component	MHC class II protein complex
S	0042802	molecular_function	identical protein binding
S	0042803	molecular_function	protein homodimerization activity
S	0042824	cellular_component	MHC class I peptide loading complex
S	0048260	biological_process	positive regulation of receptor-mediated endocytosis
S	0048261	biological_process	negative regulation of receptor-mediated endocytosis
S	0050680	biological_process	negative regulation of epithelial cell proliferation
S	0050768	biological_process	negative regulation of neurogenesis
S	0050778	biological_process	positive regulation of immune response
S	0050870	biological_process	positive regulation of T cell activation
S	0051289	biological_process	protein homotetramerization
S	0055038	cellular_component	recycling endosome membrane
S	0070062	cellular_component	extracellular exosome
S	0071281	biological_process	cellular response to iron ion
S	0071316	biological_process	cellular response to nicotine
S	1904724	cellular_component	tertiary granule lumen
S	1990000	biological_process	amyloid fibril formation
S	1990712	cellular_component	HFE-transferrin receptor complex
S	2000774	biological_process	positive regulation of cellular senescence
S	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
M	TYR78-HIS84
L	TYR257-HIS263

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	352
Details	Domain: {"description":"Ig-like C1-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---