8WUL

Crystal structure of affinity enhanced TCR in complex with HLA-A*11:01 bound to KRAS-G12V peptide (VVGAVGVGK)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002439	biological_process	chronic inflammatory response to antigenic stimulus
A	0003674	molecular_function	molecular_function
A	0005575	cellular_component	cellular_component
A	0008150	biological_process	biological_process
A	0010038	biological_process	response to metal ion
A	0042101	cellular_component	T cell receptor complex
A	0050852	biological_process	T cell receptor signaling pathway
C	0002439	biological_process	chronic inflammatory response to antigenic stimulus
C	0003674	molecular_function	molecular_function
C	0005575	cellular_component	cellular_component
C	0008150	biological_process	biological_process
C	0010038	biological_process	response to metal ion
C	0042101	cellular_component	T cell receptor complex
C	0050852	biological_process	T cell receptor signaling pathway
E	0002439	biological_process	chronic inflammatory response to antigenic stimulus
E	0003674	molecular_function	molecular_function
E	0005575	cellular_component	cellular_component
E	0008150	biological_process	biological_process
E	0010038	biological_process	response to metal ion
E	0042101	cellular_component	T cell receptor complex
E	0050852	biological_process	T cell receptor signaling pathway
G	0002439	biological_process	chronic inflammatory response to antigenic stimulus
G	0003674	molecular_function	molecular_function
G	0005575	cellular_component	cellular_component
G	0008150	biological_process	biological_process
G	0010038	biological_process	response to metal ion
G	0042101	cellular_component	T cell receptor complex
G	0050852	biological_process	T cell receptor signaling pathway
J	0000139	cellular_component	Golgi membrane
J	0001913	biological_process	T cell mediated cytotoxicity
J	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
J	0002237	biological_process	response to molecule of bacterial origin
J	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
J	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
J	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
J	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
J	0002726	biological_process	positive regulation of T cell cytokine production
J	0005198	molecular_function	structural molecule activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005765	cellular_component	lysosomal membrane
J	0005783	cellular_component	endoplasmic reticulum
J	0005788	cellular_component	endoplasmic reticulum lumen
J	0005794	cellular_component	Golgi apparatus
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0005925	cellular_component	focal adhesion
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006955	biological_process	immune response
J	0007608	biological_process	sensory perception of smell
J	0007611	biological_process	learning or memory
J	0009897	cellular_component	external side of plasma membrane
J	0009986	cellular_component	cell surface
J	0010977	biological_process	negative regulation of neuron projection development
J	0012507	cellular_component	ER to Golgi transport vesicle membrane
J	0016020	cellular_component	membrane
J	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
J	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
J	0023026	molecular_function	MHC class II protein complex binding
J	0030670	cellular_component	phagocytic vesicle membrane
J	0031901	cellular_component	early endosome membrane
J	0031902	cellular_component	late endosome membrane
J	0031905	cellular_component	early endosome lumen
J	0032092	biological_process	positive regulation of protein binding
J	0033077	biological_process	T cell differentiation in thymus
J	0034756	biological_process	regulation of iron ion transport
J	0035580	cellular_component	specific granule lumen
J	0042026	biological_process	protein refolding
J	0042605	molecular_function	peptide antigen binding
J	0042612	cellular_component	MHC class I protein complex
J	0042613	cellular_component	MHC class II protein complex
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0042824	cellular_component	MHC class I peptide loading complex
J	0045646	biological_process	regulation of erythrocyte differentiation
J	0048260	biological_process	positive regulation of receptor-mediated endocytosis
J	0050680	biological_process	negative regulation of epithelial cell proliferation
J	0050768	biological_process	negative regulation of neurogenesis
J	0050778	biological_process	positive regulation of immune response
J	0050870	biological_process	positive regulation of T cell activation
J	0051289	biological_process	protein homotetramerization
J	0055038	cellular_component	recycling endosome membrane
J	0060586	biological_process	multicellular organismal-level iron ion homeostasis
J	0070062	cellular_component	extracellular exosome
J	0071281	biological_process	cellular response to iron ion
J	0071283	biological_process	cellular response to iron(III) ion
J	0071316	biological_process	cellular response to nicotine
J	1900121	biological_process	negative regulation of receptor binding
J	1900122	biological_process	positive regulation of receptor binding
J	1904434	biological_process	positive regulation of ferrous iron binding
J	1904437	biological_process	positive regulation of transferrin receptor binding
J	1904724	cellular_component	tertiary granule lumen
J	1990000	biological_process	amyloid fibril formation
J	1990712	cellular_component	HFE-transferrin receptor complex
J	2000774	biological_process	positive regulation of cellular senescence
J	2000978	biological_process	negative regulation of forebrain neuron differentiation
M	0000139	cellular_component	Golgi membrane
M	0001913	biological_process	T cell mediated cytotoxicity
M	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
M	0002237	biological_process	response to molecule of bacterial origin
M	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
M	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
M	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
M	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
M	0002726	biological_process	positive regulation of T cell cytokine production
M	0005198	molecular_function	structural molecule activity
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005765	cellular_component	lysosomal membrane
M	0005783	cellular_component	endoplasmic reticulum
M	0005788	cellular_component	endoplasmic reticulum lumen
M	0005794	cellular_component	Golgi apparatus
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0005925	cellular_component	focal adhesion
M	0006826	biological_process	iron ion transport
M	0006879	biological_process	intracellular iron ion homeostasis
M	0006955	biological_process	immune response
M	0007608	biological_process	sensory perception of smell
M	0007611	biological_process	learning or memory
M	0009897	cellular_component	external side of plasma membrane
M	0009986	cellular_component	cell surface
M	0010977	biological_process	negative regulation of neuron projection development
M	0012507	cellular_component	ER to Golgi transport vesicle membrane
M	0016020	cellular_component	membrane
M	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
M	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
M	0023026	molecular_function	MHC class II protein complex binding
M	0030670	cellular_component	phagocytic vesicle membrane
M	0031901	cellular_component	early endosome membrane
M	0031902	cellular_component	late endosome membrane
M	0031905	cellular_component	early endosome lumen
M	0032092	biological_process	positive regulation of protein binding
M	0033077	biological_process	T cell differentiation in thymus
M	0034756	biological_process	regulation of iron ion transport
M	0035580	cellular_component	specific granule lumen
M	0042026	biological_process	protein refolding
M	0042605	molecular_function	peptide antigen binding
M	0042612	cellular_component	MHC class I protein complex
M	0042613	cellular_component	MHC class II protein complex
M	0042802	molecular_function	identical protein binding
M	0042803	molecular_function	protein homodimerization activity
M	0042824	cellular_component	MHC class I peptide loading complex
M	0045646	biological_process	regulation of erythrocyte differentiation
M	0048260	biological_process	positive regulation of receptor-mediated endocytosis
M	0050680	biological_process	negative regulation of epithelial cell proliferation
M	0050768	biological_process	negative regulation of neurogenesis
M	0050778	biological_process	positive regulation of immune response
M	0050870	biological_process	positive regulation of T cell activation
M	0051289	biological_process	protein homotetramerization
M	0055038	cellular_component	recycling endosome membrane
M	0060586	biological_process	multicellular organismal-level iron ion homeostasis
M	0070062	cellular_component	extracellular exosome
M	0071281	biological_process	cellular response to iron ion
M	0071283	biological_process	cellular response to iron(III) ion
M	0071316	biological_process	cellular response to nicotine
M	1900121	biological_process	negative regulation of receptor binding
M	1900122	biological_process	positive regulation of receptor binding
M	1904434	biological_process	positive regulation of ferrous iron binding
M	1904437	biological_process	positive regulation of transferrin receptor binding
M	1904724	cellular_component	tertiary granule lumen
M	1990000	biological_process	amyloid fibril formation
M	1990712	cellular_component	HFE-transferrin receptor complex
M	2000774	biological_process	positive regulation of cellular senescence
M	2000978	biological_process	negative regulation of forebrain neuron differentiation
P	0000139	cellular_component	Golgi membrane
P	0001913	biological_process	T cell mediated cytotoxicity
P	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
P	0002237	biological_process	response to molecule of bacterial origin
P	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
P	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
P	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
P	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
P	0002726	biological_process	positive regulation of T cell cytokine production
P	0005198	molecular_function	structural molecule activity
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0005765	cellular_component	lysosomal membrane
P	0005783	cellular_component	endoplasmic reticulum
P	0005788	cellular_component	endoplasmic reticulum lumen
P	0005794	cellular_component	Golgi apparatus
P	0005829	cellular_component	cytosol
P	0005886	cellular_component	plasma membrane
P	0005925	cellular_component	focal adhesion
P	0006826	biological_process	iron ion transport
P	0006879	biological_process	intracellular iron ion homeostasis
P	0006955	biological_process	immune response
P	0007608	biological_process	sensory perception of smell
P	0007611	biological_process	learning or memory
P	0009897	cellular_component	external side of plasma membrane
P	0009986	cellular_component	cell surface
P	0010977	biological_process	negative regulation of neuron projection development
P	0012507	cellular_component	ER to Golgi transport vesicle membrane
P	0016020	cellular_component	membrane
P	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
P	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
P	0023026	molecular_function	MHC class II protein complex binding
P	0030670	cellular_component	phagocytic vesicle membrane
P	0031901	cellular_component	early endosome membrane
P	0031902	cellular_component	late endosome membrane
P	0031905	cellular_component	early endosome lumen
P	0032092	biological_process	positive regulation of protein binding
P	0033077	biological_process	T cell differentiation in thymus
P	0034756	biological_process	regulation of iron ion transport
P	0035580	cellular_component	specific granule lumen
P	0042026	biological_process	protein refolding
P	0042605	molecular_function	peptide antigen binding
P	0042612	cellular_component	MHC class I protein complex
P	0042613	cellular_component	MHC class II protein complex
P	0042802	molecular_function	identical protein binding
P	0042803	molecular_function	protein homodimerization activity
P	0042824	cellular_component	MHC class I peptide loading complex
P	0045646	biological_process	regulation of erythrocyte differentiation
P	0048260	biological_process	positive regulation of receptor-mediated endocytosis
P	0050680	biological_process	negative regulation of epithelial cell proliferation
P	0050768	biological_process	negative regulation of neurogenesis
P	0050778	biological_process	positive regulation of immune response
P	0050870	biological_process	positive regulation of T cell activation
P	0051289	biological_process	protein homotetramerization
P	0055038	cellular_component	recycling endosome membrane
P	0060586	biological_process	multicellular organismal-level iron ion homeostasis
P	0070062	cellular_component	extracellular exosome
P	0071281	biological_process	cellular response to iron ion
P	0071283	biological_process	cellular response to iron(III) ion
P	0071316	biological_process	cellular response to nicotine
P	1900121	biological_process	negative regulation of receptor binding
P	1900122	biological_process	positive regulation of receptor binding
P	1904434	biological_process	positive regulation of ferrous iron binding
P	1904437	biological_process	positive regulation of transferrin receptor binding
P	1904724	cellular_component	tertiary granule lumen
P	1990000	biological_process	amyloid fibril formation
P	1990712	cellular_component	HFE-transferrin receptor complex
P	2000774	biological_process	positive regulation of cellular senescence
P	2000978	biological_process	negative regulation of forebrain neuron differentiation
S	0000139	cellular_component	Golgi membrane
S	0001913	biological_process	T cell mediated cytotoxicity
S	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
S	0002237	biological_process	response to molecule of bacterial origin
S	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
S	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
S	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
S	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
S	0002726	biological_process	positive regulation of T cell cytokine production
S	0005198	molecular_function	structural molecule activity
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005615	cellular_component	extracellular space
S	0005765	cellular_component	lysosomal membrane
S	0005783	cellular_component	endoplasmic reticulum
S	0005788	cellular_component	endoplasmic reticulum lumen
S	0005794	cellular_component	Golgi apparatus
S	0005829	cellular_component	cytosol
S	0005886	cellular_component	plasma membrane
S	0005925	cellular_component	focal adhesion
S	0006826	biological_process	iron ion transport
S	0006879	biological_process	intracellular iron ion homeostasis
S	0006955	biological_process	immune response
S	0007608	biological_process	sensory perception of smell
S	0007611	biological_process	learning or memory
S	0009897	cellular_component	external side of plasma membrane
S	0009986	cellular_component	cell surface
S	0010977	biological_process	negative regulation of neuron projection development
S	0012507	cellular_component	ER to Golgi transport vesicle membrane
S	0016020	cellular_component	membrane
S	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
S	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
S	0023026	molecular_function	MHC class II protein complex binding
S	0030670	cellular_component	phagocytic vesicle membrane
S	0031901	cellular_component	early endosome membrane
S	0031902	cellular_component	late endosome membrane
S	0031905	cellular_component	early endosome lumen
S	0032092	biological_process	positive regulation of protein binding
S	0033077	biological_process	T cell differentiation in thymus
S	0034756	biological_process	regulation of iron ion transport
S	0035580	cellular_component	specific granule lumen
S	0042026	biological_process	protein refolding
S	0042605	molecular_function	peptide antigen binding
S	0042612	cellular_component	MHC class I protein complex
S	0042613	cellular_component	MHC class II protein complex
S	0042802	molecular_function	identical protein binding
S	0042803	molecular_function	protein homodimerization activity
S	0042824	cellular_component	MHC class I peptide loading complex
S	0045646	biological_process	regulation of erythrocyte differentiation
S	0048260	biological_process	positive regulation of receptor-mediated endocytosis
S	0050680	biological_process	negative regulation of epithelial cell proliferation
S	0050768	biological_process	negative regulation of neurogenesis
S	0050778	biological_process	positive regulation of immune response
S	0050870	biological_process	positive regulation of T cell activation
S	0051289	biological_process	protein homotetramerization
S	0055038	cellular_component	recycling endosome membrane
S	0060586	biological_process	multicellular organismal-level iron ion homeostasis
S	0070062	cellular_component	extracellular exosome
S	0071281	biological_process	cellular response to iron ion
S	0071283	biological_process	cellular response to iron(III) ion
S	0071316	biological_process	cellular response to nicotine
S	1900121	biological_process	negative regulation of receptor binding
S	1900122	biological_process	positive regulation of receptor binding
S	1904434	biological_process	positive regulation of ferrous iron binding
S	1904437	biological_process	positive regulation of transferrin receptor binding
S	1904724	cellular_component	tertiary granule lumen
S	1990000	biological_process	amyloid fibril formation
S	1990712	cellular_component	HFE-transferrin receptor complex
S	2000774	biological_process	positive regulation of cellular senescence
S	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
M	TYR78-HIS84
L	TYR257-HIS263

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140

Chain	Residue	Details
N	GLY3
K	GLY3
Q	GLY3
T	GLY3
E	ASN178
E	ASN192
G	ASN178
G	ASN192

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443

Chain	Residue	Details
M	ILE1
J	ILE1
P	ILE1
S	ILE1

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443

Chain	Residue	Details
M	LYS19
J	LYS58
J	LYS91
J	LYS94
P	LYS19
P	LYS41
P	LYS48
P	LYS58
P	LYS91
P	LYS94
S	LYS19
M	LYS41
S	LYS41
S	LYS48
S	LYS58
S	LYS91
S	LYS94
M	LYS48
M	LYS58
M	LYS91
M	LYS94
J	LYS19
J	LYS41
J	LYS48

---