8WMP

Crystal Structure of Mutant HisB from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000105	biological_process	L-histidine biosynthetic process
A	0003824	molecular_function	catalytic activity
A	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
A	0005737	cellular_component	cytoplasm
A	0008652	biological_process	amino acid biosynthetic process
A	0016829	molecular_function	lyase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00954
Number of Residues	14
Details	IGP_DEHYDRATASE_1 Imidazoleglycerol-phosphate dehydratase signature 1. IEaHHtiEdtAIAL

Chain	Residue	Details
A	ILE70-LEU83

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site_id	PS00955
Number of Residues	13
Details	IGP_DEHYDRATASE_2 Imidazoleglycerol-phosphate dehydratase signature 2. GrDpHHitEAqYK

Chain	Residue	Details
A	GLY172-LYS184

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O23346

Chain	Residue	Details
A	GLU21
A	ARG99
A	ARG121
A	SER205

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:24311587, ECO:0007744|PDB:4GQU

Chain	Residue	Details
A	HIS47
A	HIS73
A	HIS74
A	GLU77
A	HIS152
A	HIS176
A	HIS177
A	GLU180

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