8WFS

Cryo-EM structure of GPIb-IX Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
b	0004888	molecular_function	transmembrane signaling receptor activity
b	0005515	molecular_function	protein binding
b	0005886	cellular_component	plasma membrane
b	0007155	biological_process	cell adhesion
b	0007166	biological_process	cell surface receptor signaling pathway
b	0007596	biological_process	blood coagulation
b	0007597	biological_process	blood coagulation, intrinsic pathway
b	0007599	biological_process	hemostasis
b	0010572	biological_process	positive regulation of platelet activation
b	0016020	cellular_component	membrane
b	0030168	biological_process	platelet activation
b	0035855	biological_process	megakaryocyte development
b	0042802	molecular_function	identical protein binding
b	0051209	biological_process	release of sequestered calcium ion into cytosol
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0007155	biological_process	cell adhesion
B	0007166	biological_process	cell surface receptor signaling pathway
B	0007596	biological_process	blood coagulation
B	0007597	biological_process	blood coagulation, intrinsic pathway
B	0007599	biological_process	hemostasis
B	0010572	biological_process	positive regulation of platelet activation
B	0016020	cellular_component	membrane
B	0030168	biological_process	platelet activation
B	0035855	biological_process	megakaryocyte development
B	0042802	molecular_function	identical protein binding
B	0051209	biological_process	release of sequestered calcium ion into cytosol
c	0004888	molecular_function	transmembrane signaling receptor activity
c	0005515	molecular_function	protein binding
c	0005886	cellular_component	plasma membrane
c	0007155	biological_process	cell adhesion
c	0007166	biological_process	cell surface receptor signaling pathway
c	0007596	biological_process	blood coagulation
c	0007597	biological_process	blood coagulation, intrinsic pathway
c	0007599	biological_process	hemostasis
c	0010572	biological_process	positive regulation of platelet activation
c	0016020	cellular_component	membrane
c	0030168	biological_process	platelet activation
c	0035855	biological_process	megakaryocyte development
c	0042802	molecular_function	identical protein binding
c	0051209	biological_process	release of sequestered calcium ion into cytosol
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0007155	biological_process	cell adhesion
C	0007166	biological_process	cell surface receptor signaling pathway
C	0007596	biological_process	blood coagulation
C	0007597	biological_process	blood coagulation, intrinsic pathway
C	0007599	biological_process	hemostasis
C	0010572	biological_process	positive regulation of platelet activation
C	0016020	cellular_component	membrane
C	0030168	biological_process	platelet activation
C	0035855	biological_process	megakaryocyte development
C	0042802	molecular_function	identical protein binding
C	0051209	biological_process	release of sequestered calcium ion into cytosol
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0007155	biological_process	cell adhesion
E	0007596	biological_process	blood coagulation
E	0007597	biological_process	blood coagulation, intrinsic pathway
E	0007599	biological_process	hemostasis
E	0010572	biological_process	positive regulation of platelet activation
E	0016020	cellular_component	membrane
E	0035855	biological_process	megakaryocyte development
E	0051209	biological_process	release of sequestered calcium ion into cytosol
X	0005515	molecular_function	protein binding
X	0005886	cellular_component	plasma membrane
X	0007155	biological_process	cell adhesion
X	0007596	biological_process	blood coagulation
X	0007597	biological_process	blood coagulation, intrinsic pathway
X	0007599	biological_process	hemostasis
X	0010572	biological_process	positive regulation of platelet activation
X	0016020	cellular_component	membrane
X	0035855	biological_process	megakaryocyte development
X	0051209	biological_process	release of sequestered calcium ion into cytosol

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	180
Details	Domain: {"description":"LRRNT"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	138
Details	Repeat: {"description":"LRR"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	266
Details	Domain: {"description":"LRRCT"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21908432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3353370","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	370
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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