8WDT

Crystal structure of the human adenosine A2A receptor in complex with photoresponsive ligand photoNECA(blue)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001609	molecular_function	G protein-coupled adenosine receptor activity
A	0001973	biological_process	G protein-coupled adenosine receptor signaling pathway
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIfSLLAIAIDRYIaI

Chain	Residue	Details
A	SER90-ILE106

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
B	TYR191-HIS197

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	VAL8-TRP32

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site_id	SWS_FT_FI2
Number of Residues	63
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:18832607

Chain	Residue	Details
A	LEU33-ASN42
A	ASP101-ARG120
A	ALA199-SER234

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site_id	SWS_FT_FI3
Number of Residues	23
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	TYR43-ILE66

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site_id	SWS_FT_FI4
Number of Residues	46
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:18832607

Chain	Residue	Details
A	SER67-CYS77
A	ASN144-PRO173
A	CYS259-PRO266

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site_id	SWS_FT_FI5
Number of Residues	22
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU78-ILE100

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site_id	SWS_FT_FI6
Number of Residues	22
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	ALA121-TRP143

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site_id	SWS_FT_FI7
Number of Residues	24
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	MET174-LEU198

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site_id	SWS_FT_FI8
Number of Residues	23
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	LEU235-PHE258

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site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	LEU267-TYR290

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site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:21593763, ECO:0007744|PDB:2YDO

Chain	Residue	Details
A	GLU169
A	ASN253
A	SER277
A	HIS278

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site_id	SWS_FT_FI11
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	GLN154

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