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8W2H

Human liver phosphofructokinase-1 in the T-state conformation

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003824molecular_functioncatalytic activity
A0003872molecular_function6-phosphofructokinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005945cellular_component6-phosphofructokinase complex
A0006002biological_processfructose 6-phosphate metabolic process
A0006096biological_processglycolytic process
A0009749biological_processresponse to glucose
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0019900molecular_functionkinase binding
A0030388biological_processfructose 1,6-bisphosphate metabolic process
A0034774cellular_componentsecretory granule lumen
A0042802molecular_functionidentical protein binding
A0046676biological_processnegative regulation of insulin secretion
A0046872molecular_functionmetal ion binding
A0048029molecular_functionmonosaccharide binding
A0061615biological_processglycolytic process through fructose-6-phosphate
A0061621biological_processcanonical glycolysis
A0070061molecular_functionfructose binding
A0070062cellular_componentextracellular exosome
A0070095molecular_functionfructose-6-phosphate binding
A1904813cellular_componentficolin-1-rich granule lumen
B0000166molecular_functionnucleotide binding
B0003824molecular_functioncatalytic activity
B0003872molecular_function6-phosphofructokinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005576cellular_componentextracellular region
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005945cellular_component6-phosphofructokinase complex
B0006002biological_processfructose 6-phosphate metabolic process
B0006096biological_processglycolytic process
B0009749biological_processresponse to glucose
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0019900molecular_functionkinase binding
B0030388biological_processfructose 1,6-bisphosphate metabolic process
B0034774cellular_componentsecretory granule lumen
B0042802molecular_functionidentical protein binding
B0046676biological_processnegative regulation of insulin secretion
B0046872molecular_functionmetal ion binding
B0048029molecular_functionmonosaccharide binding
B0061615biological_processglycolytic process through fructose-6-phosphate
B0061621biological_processcanonical glycolysis
B0070061molecular_functionfructose binding
B0070062cellular_componentextracellular exosome
B0070095molecular_functionfructose-6-phosphate binding
B1904813cellular_componentficolin-1-rich granule lumen
C0000166molecular_functionnucleotide binding
C0003824molecular_functioncatalytic activity
C0003872molecular_function6-phosphofructokinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005576cellular_componentextracellular region
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005945cellular_component6-phosphofructokinase complex
C0006002biological_processfructose 6-phosphate metabolic process
C0006096biological_processglycolytic process
C0009749biological_processresponse to glucose
C0016020cellular_componentmembrane
C0016301molecular_functionkinase activity
C0016740molecular_functiontransferase activity
C0019900molecular_functionkinase binding
C0030388biological_processfructose 1,6-bisphosphate metabolic process
C0034774cellular_componentsecretory granule lumen
C0042802molecular_functionidentical protein binding
C0046676biological_processnegative regulation of insulin secretion
C0046872molecular_functionmetal ion binding
C0048029molecular_functionmonosaccharide binding
C0061615biological_processglycolytic process through fructose-6-phosphate
C0061621biological_processcanonical glycolysis
C0070061molecular_functionfructose binding
C0070062cellular_componentextracellular exosome
C0070095molecular_functionfructose-6-phosphate binding
C1904813cellular_componentficolin-1-rich granule lumen
D0000166molecular_functionnucleotide binding
D0003824molecular_functioncatalytic activity
D0003872molecular_function6-phosphofructokinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005576cellular_componentextracellular region
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005945cellular_component6-phosphofructokinase complex
D0006002biological_processfructose 6-phosphate metabolic process
D0006096biological_processglycolytic process
D0009749biological_processresponse to glucose
D0016020cellular_componentmembrane
D0016301molecular_functionkinase activity
D0016740molecular_functiontransferase activity
D0019900molecular_functionkinase binding
D0030388biological_processfructose 1,6-bisphosphate metabolic process
D0034774cellular_componentsecretory granule lumen
D0042802molecular_functionidentical protein binding
D0046676biological_processnegative regulation of insulin secretion
D0046872molecular_functionmetal ion binding
D0048029molecular_functionmonosaccharide binding
D0061615biological_processglycolytic process through fructose-6-phosphate
D0061621biological_processcanonical glycolysis
D0070061molecular_functionfructose binding
D0070062cellular_componentextracellular exosome
D0070095molecular_functionfructose-6-phosphate binding
D1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PROSITE/UniProt
site_idPS00433
Number of Residues19
DetailsPHOSPHOFRUCTOKINASE Phosphofructokinase signature. RvtvlGHvQRGGtpsafDR
ChainResidueDetails
AARG292-ARG310
AARG654-ARG672

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues36
DetailsRegion: {"description":"Interdomain linker"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_03184","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues40
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03184","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues80
DetailsBinding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_03184","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P47857","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P12382","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues4
DetailsGlycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"PubMed","id":"22923583","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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