Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8W0Z

Human LCAD complexed with Lauric Acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001659	biological_process	temperature homeostasis
A	0003995	molecular_function	acyl-CoA dehydrogenase activity
A	0004466	molecular_function	long-chain fatty acyl-CoA dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0016042	biological_process	lipid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
A	0019254	biological_process	carnitine metabolic process, CoA-linked
A	0031966	cellular_component	mitochondrial membrane
A	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A	0042413	biological_process	carnitine catabolic process
A	0042758	biological_process	long-chain fatty acid catabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0045717	biological_process	negative regulation of fatty acid biosynthetic process
A	0046322	biological_process	negative regulation of fatty acid oxidation
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0070991	molecular_function	medium-chain fatty acyl-CoA dehydrogenase activity
A	0090181	biological_process	regulation of cholesterol metabolic process
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	0001659	biological_process	temperature homeostasis
B	0003995	molecular_function	acyl-CoA dehydrogenase activity
B	0004466	molecular_function	long-chain fatty acyl-CoA dehydrogenase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0016042	biological_process	lipid catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
B	0019254	biological_process	carnitine metabolic process, CoA-linked
B	0031966	cellular_component	mitochondrial membrane
B	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B	0042413	biological_process	carnitine catabolic process
B	0042758	biological_process	long-chain fatty acid catabolic process
B	0042803	molecular_function	protein homodimerization activity
B	0045717	biological_process	negative regulation of fatty acid biosynthetic process
B	0046322	biological_process	negative regulation of fatty acid oxidation
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0070991	molecular_function	medium-chain fatty acyl-CoA dehydrogenase activity
B	0090181	biological_process	regulation of cholesterol metabolic process
B	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	0001659	biological_process	temperature homeostasis
C	0003995	molecular_function	acyl-CoA dehydrogenase activity
C	0004466	molecular_function	long-chain fatty acyl-CoA dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0016042	biological_process	lipid catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
C	0019254	biological_process	carnitine metabolic process, CoA-linked
C	0031966	cellular_component	mitochondrial membrane
C	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C	0042413	biological_process	carnitine catabolic process
C	0042758	biological_process	long-chain fatty acid catabolic process
C	0042803	molecular_function	protein homodimerization activity
C	0045717	biological_process	negative regulation of fatty acid biosynthetic process
C	0046322	biological_process	negative regulation of fatty acid oxidation
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	0070991	molecular_function	medium-chain fatty acyl-CoA dehydrogenase activity
C	0090181	biological_process	regulation of cholesterol metabolic process
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
D	0001659	biological_process	temperature homeostasis
D	0003995	molecular_function	acyl-CoA dehydrogenase activity
D	0004466	molecular_function	long-chain fatty acyl-CoA dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0016042	biological_process	lipid catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
D	0019254	biological_process	carnitine metabolic process, CoA-linked
D	0031966	cellular_component	mitochondrial membrane
D	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D	0042413	biological_process	carnitine catabolic process
D	0042758	biological_process	long-chain fatty acid catabolic process
D	0042803	molecular_function	protein homodimerization activity
D	0045717	biological_process	negative regulation of fatty acid biosynthetic process
D	0046322	biological_process	negative regulation of fatty acid oxidation
D	0050660	molecular_function	flavin adenine dinucleotide binding
D	0070991	molecular_function	medium-chain fatty acyl-CoA dehydrogenase activity
D	0090181	biological_process	regulation of cholesterol metabolic process
D	0120162	biological_process	positive regulation of cold-induced thermogenesis
E	0001659	biological_process	temperature homeostasis
E	0003995	molecular_function	acyl-CoA dehydrogenase activity
E	0004466	molecular_function	long-chain fatty acyl-CoA dehydrogenase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0016042	biological_process	lipid catabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
E	0019254	biological_process	carnitine metabolic process, CoA-linked
E	0031966	cellular_component	mitochondrial membrane
E	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E	0042413	biological_process	carnitine catabolic process
E	0042758	biological_process	long-chain fatty acid catabolic process
E	0042803	molecular_function	protein homodimerization activity
E	0045717	biological_process	negative regulation of fatty acid biosynthetic process
E	0046322	biological_process	negative regulation of fatty acid oxidation
E	0050660	molecular_function	flavin adenine dinucleotide binding
E	0070991	molecular_function	medium-chain fatty acyl-CoA dehydrogenase activity
E	0090181	biological_process	regulation of cholesterol metabolic process
E	0120162	biological_process	positive regulation of cold-induced thermogenesis
F	0001659	biological_process	temperature homeostasis
F	0003995	molecular_function	acyl-CoA dehydrogenase activity
F	0004466	molecular_function	long-chain fatty acyl-CoA dehydrogenase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006629	biological_process	lipid metabolic process
F	0006631	biological_process	fatty acid metabolic process
F	0016042	biological_process	lipid catabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
F	0019254	biological_process	carnitine metabolic process, CoA-linked
F	0031966	cellular_component	mitochondrial membrane
F	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F	0042413	biological_process	carnitine catabolic process
F	0042758	biological_process	long-chain fatty acid catabolic process
F	0042803	molecular_function	protein homodimerization activity
F	0045717	biological_process	negative regulation of fatty acid biosynthetic process
F	0046322	biological_process	negative regulation of fatty acid oxidation
F	0050660	molecular_function	flavin adenine dinucleotide binding
F	0070991	molecular_function	medium-chain fatty acyl-CoA dehydrogenase activity
F	0090181	biological_process	regulation of cholesterol metabolic process
F	0120162	biological_process	positive regulation of cold-induced thermogenesis
G	0001659	biological_process	temperature homeostasis
G	0003995	molecular_function	acyl-CoA dehydrogenase activity
G	0004466	molecular_function	long-chain fatty acyl-CoA dehydrogenase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0006629	biological_process	lipid metabolic process
G	0006631	biological_process	fatty acid metabolic process
G	0016042	biological_process	lipid catabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
G	0019254	biological_process	carnitine metabolic process, CoA-linked
G	0031966	cellular_component	mitochondrial membrane
G	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G	0042413	biological_process	carnitine catabolic process
G	0042758	biological_process	long-chain fatty acid catabolic process
G	0042803	molecular_function	protein homodimerization activity
G	0045717	biological_process	negative regulation of fatty acid biosynthetic process
G	0046322	biological_process	negative regulation of fatty acid oxidation
G	0050660	molecular_function	flavin adenine dinucleotide binding
G	0070991	molecular_function	medium-chain fatty acyl-CoA dehydrogenase activity
G	0090181	biological_process	regulation of cholesterol metabolic process
G	0120162	biological_process	positive regulation of cold-induced thermogenesis
H	0001659	biological_process	temperature homeostasis
H	0003995	molecular_function	acyl-CoA dehydrogenase activity
H	0004466	molecular_function	long-chain fatty acyl-CoA dehydrogenase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0006629	biological_process	lipid metabolic process
H	0006631	biological_process	fatty acid metabolic process
H	0016042	biological_process	lipid catabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
H	0019254	biological_process	carnitine metabolic process, CoA-linked
H	0031966	cellular_component	mitochondrial membrane
H	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H	0042413	biological_process	carnitine catabolic process
H	0042758	biological_process	long-chain fatty acid catabolic process
H	0042803	molecular_function	protein homodimerization activity
H	0045717	biological_process	negative regulation of fatty acid biosynthetic process
H	0046322	biological_process	negative regulation of fatty acid oxidation
H	0050660	molecular_function	flavin adenine dinucleotide binding
H	0070991	molecular_function	medium-chain fatty acyl-CoA dehydrogenase activity
H	0090181	biological_process	regulation of cholesterol metabolic process
H	0120162	biological_process	positive regulation of cold-induced thermogenesis

Functional Information from PROSITE/UniProt

site_id	PS00072
Number of Residues	13
Details	ACYL_COA_DH_1 Acyl-CoA dehydrogenases signature 1. AMTEpgAGSDlqG

Chain	Residue	Details
A	ALA171-GLY183

site_id	PS00073
Number of Residues	20
Details	ACYL_COA_DH_2 Acyl-CoA dehydrogenases signature 2. QlHGGwGYmwEypiaKayvD

Chain	Residue	Details
A	GLN385-ASP404

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"8155643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	208
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P26440","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	40
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P51174","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P15650","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	40
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P51174","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	16
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P51174","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P51174","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)