Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8W0U

Human LCAD complexed with Acetoacetyl Coenzyme A

Functional Information from GO Data
ChainGOidnamespacecontents
A0001659biological_processtemperature homeostasis
A0003995molecular_functionacyl-CoA dehydrogenase activity
A0004466molecular_functionlong-chain fatty acyl-CoA dehydrogenase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0016042biological_processlipid catabolic process
A0016491molecular_functionoxidoreductase activity
A0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
A0019254biological_processcarnitine metabolic process, CoA-linked
A0031966cellular_componentmitochondrial membrane
A0033539biological_processfatty acid beta-oxidation using acyl-CoA dehydrogenase
A0042413biological_processcarnitine catabolic process
A0042758biological_processlong-chain fatty acid catabolic process
A0042803molecular_functionprotein homodimerization activity
A0045717biological_processnegative regulation of fatty acid biosynthetic process
A0046322biological_processnegative regulation of fatty acid oxidation
A0050660molecular_functionflavin adenine dinucleotide binding
A0070991molecular_functionmedium-chain fatty acyl-CoA dehydrogenase activity
A0090181biological_processregulation of cholesterol metabolic process
A0120162biological_processpositive regulation of cold-induced thermogenesis
B0001659biological_processtemperature homeostasis
B0003995molecular_functionacyl-CoA dehydrogenase activity
B0004466molecular_functionlong-chain fatty acyl-CoA dehydrogenase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0016042biological_processlipid catabolic process
B0016491molecular_functionoxidoreductase activity
B0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
B0019254biological_processcarnitine metabolic process, CoA-linked
B0031966cellular_componentmitochondrial membrane
B0033539biological_processfatty acid beta-oxidation using acyl-CoA dehydrogenase
B0042413biological_processcarnitine catabolic process
B0042758biological_processlong-chain fatty acid catabolic process
B0042803molecular_functionprotein homodimerization activity
B0045717biological_processnegative regulation of fatty acid biosynthetic process
B0046322biological_processnegative regulation of fatty acid oxidation
B0050660molecular_functionflavin adenine dinucleotide binding
B0070991molecular_functionmedium-chain fatty acyl-CoA dehydrogenase activity
B0090181biological_processregulation of cholesterol metabolic process
B0120162biological_processpositive regulation of cold-induced thermogenesis
C0001659biological_processtemperature homeostasis
C0003995molecular_functionacyl-CoA dehydrogenase activity
C0004466molecular_functionlong-chain fatty acyl-CoA dehydrogenase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0006629biological_processlipid metabolic process
C0006631biological_processfatty acid metabolic process
C0016042biological_processlipid catabolic process
C0016491molecular_functionoxidoreductase activity
C0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
C0019254biological_processcarnitine metabolic process, CoA-linked
C0031966cellular_componentmitochondrial membrane
C0033539biological_processfatty acid beta-oxidation using acyl-CoA dehydrogenase
C0042413biological_processcarnitine catabolic process
C0042758biological_processlong-chain fatty acid catabolic process
C0042803molecular_functionprotein homodimerization activity
C0045717biological_processnegative regulation of fatty acid biosynthetic process
C0046322biological_processnegative regulation of fatty acid oxidation
C0050660molecular_functionflavin adenine dinucleotide binding
C0070991molecular_functionmedium-chain fatty acyl-CoA dehydrogenase activity
C0090181biological_processregulation of cholesterol metabolic process
C0120162biological_processpositive regulation of cold-induced thermogenesis
D0001659biological_processtemperature homeostasis
D0003995molecular_functionacyl-CoA dehydrogenase activity
D0004466molecular_functionlong-chain fatty acyl-CoA dehydrogenase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0006629biological_processlipid metabolic process
D0006631biological_processfatty acid metabolic process
D0016042biological_processlipid catabolic process
D0016491molecular_functionoxidoreductase activity
D0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
D0019254biological_processcarnitine metabolic process, CoA-linked
D0031966cellular_componentmitochondrial membrane
D0033539biological_processfatty acid beta-oxidation using acyl-CoA dehydrogenase
D0042413biological_processcarnitine catabolic process
D0042758biological_processlong-chain fatty acid catabolic process
D0042803molecular_functionprotein homodimerization activity
D0045717biological_processnegative regulation of fatty acid biosynthetic process
D0046322biological_processnegative regulation of fatty acid oxidation
D0050660molecular_functionflavin adenine dinucleotide binding
D0070991molecular_functionmedium-chain fatty acyl-CoA dehydrogenase activity
D0090181biological_processregulation of cholesterol metabolic process
D0120162biological_processpositive regulation of cold-induced thermogenesis
Functional Information from PROSITE/UniProt
site_idPS00072
Number of Residues13
DetailsACYL_COA_DH_1 Acyl-CoA dehydrogenases signature 1. AMTEpgAGSDlqG
ChainResidueDetails
AALA171-GLY183
site_idPS00073
Number of Residues20
DetailsACYL_COA_DH_2 Acyl-CoA dehydrogenases signature 2. QlHGGwGYmwEypiaKayvD
ChainResidueDetails
AGLN385-ASP404
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"8155643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues104
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P26440","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues20
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P51174","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P15650","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues20
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P51174","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P51174","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P51174","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

250059

PDB entries from 2026-03-04

PDB statisticsPDBj update infoContact PDBjnumon