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8VXJ

The crystal structure of human apolipoprotein A-I in complex with Fab 55201

Functional Information from GO Data
ChainGOidnamespacecontents
C0001540molecular_functionamyloid-beta binding
C0002719biological_processnegative regulation of cytokine production involved in immune response
C0005102molecular_functionsignaling receptor binding
C0005319molecular_functionlipid transporter activity
C0005515molecular_functionprotein binding
C0005543molecular_functionphospholipid binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005769cellular_componentearly endosome
C0005788cellular_componentendoplasmic reticulum lumen
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006629biological_processlipid metabolic process
C0006656biological_processphosphatidylcholine biosynthetic process
C0006869biological_processlipid transport
C0007179biological_processtransforming growth factor beta receptor signaling pathway
C0007186biological_processG protein-coupled receptor signaling pathway
C0007229biological_processintegrin-mediated signaling pathway
C0008035molecular_functionhigh-density lipoprotein particle binding
C0008202biological_processsteroid metabolic process
C0008203biological_processcholesterol metabolic process
C0008289molecular_functionlipid binding
C0010804biological_processnegative regulation of tumor necrosis factor-mediated signaling pathway
C0010875biological_processpositive regulation of cholesterol efflux
C0010903biological_processnegative regulation of very-low-density lipoprotein particle remodeling
C0015485molecular_functioncholesterol binding
C0018158biological_processprotein oxidation
C0018206biological_processpeptidyl-methionine modification
C0019899molecular_functionenzyme binding
C0030139cellular_componentendocytic vesicle
C0030301biological_processcholesterol transport
C0031072molecular_functionheat shock protein binding
C0031410cellular_componentcytoplasmic vesicle
C0032489biological_processregulation of Cdc42 protein signal transduction
C0032691biological_processnegative regulation of interleukin-1 beta production
C0033344biological_processcholesterol efflux
C0033700biological_processphospholipid efflux
C0034115biological_processnegative regulation of heterotypic cell-cell adhesion
C0034190molecular_functionapolipoprotein receptor binding
C0034191molecular_functionapolipoprotein A-I receptor binding
C0034205biological_processamyloid-beta formation
C0034361cellular_componentvery-low-density lipoprotein particle
C0034362cellular_componentlow-density lipoprotein particle
C0034364cellular_componenthigh-density lipoprotein particle
C0034366cellular_componentspherical high-density lipoprotein particle
C0034375biological_processhigh-density lipoprotein particle remodeling
C0034380biological_processhigh-density lipoprotein particle assembly
C0034384biological_processhigh-density lipoprotein particle clearance
C0034774cellular_componentsecretory granule lumen
C0035025biological_processpositive regulation of Rho protein signal transduction
C0042627cellular_componentchylomicron
C0042632biological_processcholesterol homeostasis
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043691biological_processreverse cholesterol transport
C0045499molecular_functionchemorepellent activity
C0048018molecular_functionreceptor ligand activity
C0050728biological_processnegative regulation of inflammatory response
C0050766biological_processpositive regulation of phagocytosis
C0050821biological_processprotein stabilization
C0050919biological_processnegative chemotaxis
C0051180biological_processvitamin transport
C0051496biological_processpositive regulation of stress fiber assembly
C0055090biological_processacylglycerol homeostasis
C0055091biological_processphospholipid homeostasis
C0060228molecular_functionphosphatidylcholine-sterol O-acyltransferase activator activity
C0060354biological_processnegative regulation of cell adhesion molecule production
C0060761biological_processnegative regulation of response to cytokine stimulus
C0070062cellular_componentextracellular exosome
C0070328biological_processtriglyceride homeostasis
C0070371biological_processERK1 and ERK2 cascade
C0070508biological_processcholesterol import
C0070653molecular_functionhigh-density lipoprotein particle receptor binding
C0071402biological_processcellular response to lipoprotein particle stimulus
C0071682cellular_componentendocytic vesicle lumen
C0071813molecular_functionlipoprotein particle binding
C0072562cellular_componentblood microparticle
C0090205biological_processpositive regulation of cholesterol metabolic process
C0120020molecular_functioncholesterol transfer activity
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C1902995biological_processpositive regulation of phospholipid efflux
C1903561cellular_componentextracellular vesicle
D0001540molecular_functionamyloid-beta binding
D0002719biological_processnegative regulation of cytokine production involved in immune response
D0005102molecular_functionsignaling receptor binding
D0005319molecular_functionlipid transporter activity
D0005515molecular_functionprotein binding
D0005543molecular_functionphospholipid binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005769cellular_componentearly endosome
D0005788cellular_componentendoplasmic reticulum lumen
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006629biological_processlipid metabolic process
D0006656biological_processphosphatidylcholine biosynthetic process
D0006869biological_processlipid transport
D0007179biological_processtransforming growth factor beta receptor signaling pathway
D0007186biological_processG protein-coupled receptor signaling pathway
D0007229biological_processintegrin-mediated signaling pathway
D0008035molecular_functionhigh-density lipoprotein particle binding
D0008202biological_processsteroid metabolic process
D0008203biological_processcholesterol metabolic process
D0008289molecular_functionlipid binding
D0010804biological_processnegative regulation of tumor necrosis factor-mediated signaling pathway
D0010875biological_processpositive regulation of cholesterol efflux
D0010903biological_processnegative regulation of very-low-density lipoprotein particle remodeling
D0015485molecular_functioncholesterol binding
D0018158biological_processprotein oxidation
D0018206biological_processpeptidyl-methionine modification
D0019899molecular_functionenzyme binding
D0030139cellular_componentendocytic vesicle
D0030301biological_processcholesterol transport
D0031072molecular_functionheat shock protein binding
D0031410cellular_componentcytoplasmic vesicle
D0032489biological_processregulation of Cdc42 protein signal transduction
D0032691biological_processnegative regulation of interleukin-1 beta production
D0033344biological_processcholesterol efflux
D0033700biological_processphospholipid efflux
D0034115biological_processnegative regulation of heterotypic cell-cell adhesion
D0034190molecular_functionapolipoprotein receptor binding
D0034191molecular_functionapolipoprotein A-I receptor binding
D0034205biological_processamyloid-beta formation
D0034361cellular_componentvery-low-density lipoprotein particle
D0034362cellular_componentlow-density lipoprotein particle
D0034364cellular_componenthigh-density lipoprotein particle
D0034366cellular_componentspherical high-density lipoprotein particle
D0034375biological_processhigh-density lipoprotein particle remodeling
D0034380biological_processhigh-density lipoprotein particle assembly
D0034384biological_processhigh-density lipoprotein particle clearance
D0034774cellular_componentsecretory granule lumen
D0035025biological_processpositive regulation of Rho protein signal transduction
D0042627cellular_componentchylomicron
D0042632biological_processcholesterol homeostasis
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043691biological_processreverse cholesterol transport
D0045499molecular_functionchemorepellent activity
D0048018molecular_functionreceptor ligand activity
D0050728biological_processnegative regulation of inflammatory response
D0050766biological_processpositive regulation of phagocytosis
D0050821biological_processprotein stabilization
D0050919biological_processnegative chemotaxis
D0051180biological_processvitamin transport
D0051496biological_processpositive regulation of stress fiber assembly
D0055090biological_processacylglycerol homeostasis
D0055091biological_processphospholipid homeostasis
D0060228molecular_functionphosphatidylcholine-sterol O-acyltransferase activator activity
D0060354biological_processnegative regulation of cell adhesion molecule production
D0060761biological_processnegative regulation of response to cytokine stimulus
D0070062cellular_componentextracellular exosome
D0070328biological_processtriglyceride homeostasis
D0070371biological_processERK1 and ERK2 cascade
D0070508biological_processcholesterol import
D0070653molecular_functionhigh-density lipoprotein particle receptor binding
D0071402biological_processcellular response to lipoprotein particle stimulus
D0071682cellular_componentendocytic vesicle lumen
D0071813molecular_functionlipoprotein particle binding
D0072562cellular_componentblood microparticle
D0090205biological_processpositive regulation of cholesterol metabolic process
D0120020molecular_functioncholesterol transfer activity
D1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
D1902995biological_processpositive regulation of phospholipid efflux
D1903561cellular_componentextracellular vesicle
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
LTYR191-HIS197

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues42
DetailsRepeat: {"description":"1"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues42
DetailsRepeat: {"description":"2"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues20
DetailsRepeat: {"description":"3; half-length"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues42
DetailsRepeat: {"description":"4"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues42
DetailsRepeat: {"description":"5"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues42
DetailsRepeat: {"description":"6"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"Methionine sulfoxide","evidences":[{"source":"PubMed","id":"12576517","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

248636

PDB entries from 2026-02-04

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