8VVY
Human Cullin-1 in complex with CAND2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000082 | biological_process | G1/S transition of mitotic cell cycle |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0007346 | biological_process | regulation of mitotic cell cycle |
| A | 0010564 | biological_process | regulation of cell cycle process |
| A | 0010824 | biological_process | regulation of centrosome duplication |
| A | 0014033 | biological_process | neural crest cell differentiation |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0019005 | cellular_component | SCF ubiquitin ligase complex |
| A | 0030510 | biological_process | regulation of BMP signaling pathway |
| A | 0031146 | biological_process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| A | 0031461 | cellular_component | cullin-RING ubiquitin ligase complex |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0032006 | biological_process | regulation of TOR signaling |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0042752 | biological_process | regulation of circadian rhythm |
| A | 0042981 | biological_process | regulation of apoptotic process |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| A | 0050727 | biological_process | regulation of inflammatory response |
| A | 0051298 | biological_process | centrosome duplication |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0060173 | biological_process | limb development |
| A | 0060271 | biological_process | cilium assembly |
| A | 0070936 | biological_process | protein K48-linked ubiquitination |
| A | 0097193 | biological_process | intrinsic apoptotic signaling pathway |
| A | 0160072 | molecular_function | ubiquitin ligase complex scaffold activity |
| A | 1901524 | biological_process | regulation of mitophagy |
| A | 1904415 | biological_process | regulation of xenophagy |
| A | 1990452 | cellular_component | Parkin-FBXW7-Cul1 ubiquitin ligase complex |
| A | 2000001 | biological_process | regulation of DNA damage checkpoint |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005829 | cellular_component | cytosol |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0010265 | biological_process | SCF complex assembly |
| C | 0016567 | biological_process | protein ubiquitination |
| C | 0017025 | molecular_function | TBP-class protein binding |
| C | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from PROSITE/UniProt
| site_id | PS01256 |
| Number of Residues | 28 |
| Details | CULLIN_1 Cullin family signature. IKkcIdiLIEKeYLeRvdgekdtYsYlA |
| Chain | Residue | Details |
| A | ILE714-ALA741 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)","evidences":[{"source":"PubMed","id":"10597293","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15537541","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18805092","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"HEAT 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"HEAT 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 13"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 14"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 15"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"HEAT 16"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"HEAT 17"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 18"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"HEAT 19"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"HEAT 20"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"HEAT 21"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 22"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"HEAT 23"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"HEAT 24"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 25"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Ramsay A.","Leung H.Y."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}}]} |
| Chain | Residue | Details |
