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8VUX

Cryo-EM structure of human ABC transporter (hABCC1) bound to cGAMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001894biological_processtissue homeostasis
A0002432biological_processgranuloma formation
A0002437biological_processinflammatory response to antigenic stimulus
A0003158biological_processendothelium development
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0006691biological_processleukotriene metabolic process
A0006749biological_processglutathione metabolic process
A0006805biological_processxenobiotic metabolic process
A0006869biological_processlipid transport
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0006979biological_processresponse to oxidative stress
A0007613biological_processmemory
A0008211biological_processglucocorticoid metabolic process
A0008559molecular_functionABC-type xenobiotic transporter activity
A0009410biological_processresponse to xenobiotic stimulus
A0009636biological_processresponse to toxic substance
A0009925cellular_componentbasal plasma membrane
A0010467biological_processgene expression
A0015127molecular_functionbilirubin transmembrane transporter activity
A0015420molecular_functionABC-type vitamin B12 transporter activity
A0015431molecular_functionABC-type glutathione S-conjugate transporter activity
A0015562molecular_functionefflux transmembrane transporter activity
A0015723biological_processbilirubin transport
A0015889biological_processcobalamin transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016328cellular_componentlateral plasma membrane
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0019370biological_processleukotriene biosynthetic process
A0021764biological_processamygdala development
A0021766biological_processhippocampus development
A0022008biological_processneurogenesis
A0022857molecular_functiontransmembrane transporter activity
A0030148biological_processsphingolipid biosynthetic process
A0033284molecular_functionATPase-coupled carboxylic acid transmembrane transporter activity
A0034040molecular_functionATPase-coupled lipid transmembrane transporter activity
A0034341biological_processresponse to type II interferon
A0034394biological_processprotein localization to cell surface
A0034405biological_processresponse to fluid shear stress
A0034599biological_processcellular response to oxidative stress
A0034634molecular_functionglutathione transmembrane transporter activity
A0034775biological_processglutathione transmembrane transport
A0035264biological_processmulticellular organism growth
A0035640biological_processexploration behavior
A0042116biological_processmacrophage activation
A0042167biological_processheme catabolic process
A0042391biological_processregulation of membrane potential
A0042554biological_processsuperoxide anion generation
A0042626molecular_functionATPase-coupled transmembrane transporter activity
A0042908biological_processxenobiotic transport
A0042910molecular_functionxenobiotic transmembrane transporter activity
A0043225molecular_functionATPase-coupled inorganic anion transmembrane transporter activity
A0043476biological_processpigment accumulation
A0045332biological_processphospholipid translocation
A0045454biological_processcell redox homeostasis
A0046624molecular_functionsphingolipid transporter activity
A0046942biological_processcarboxylic acid transport
A0046943molecular_functioncarboxylic acid transmembrane transporter activity
A0048003biological_processantigen processing and presentation of lipid antigen via MHC class Ib
A0050435biological_processamyloid-beta metabolic process
A0050665biological_processhydrogen peroxide biosynthetic process
A0050729biological_processpositive regulation of inflammatory response
A0050830biological_processdefense response to Gram-positive bacterium
A0051132biological_processNK T cell activation
A0051384biological_processresponse to glucocorticoid
A0051649biological_processestablishment of localization in cell
A0055082biological_processintracellular chemical homeostasis
A0055085biological_processtransmembrane transport
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
A0070633biological_processtransepithelial transport
A0070729biological_processcyclic nucleotide transport
A0071346biological_processcellular response to type II interferon
A0071716biological_processleukotriene transport
A0072577biological_processendothelial cell apoptotic process
A0072676biological_processlymphocyte migration
A0097242biological_processamyloid-beta clearance
A0097719biological_processneural tissue regeneration
A0097746biological_processblood vessel diameter maintenance
A0098656biological_processmonoatomic anion transmembrane transport
A0099039biological_processsphingolipid translocation
A0140115biological_processexport across plasma membrane
A0140352biological_processexport from cell
A0140359molecular_functionABC-type transporter activity
A0141067biological_processintracellular nitrogen homeostasis
A0150104biological_processtransport across blood-brain barrier
A1903409biological_processreactive oxygen species biosynthetic process
A1904646biological_processcellular response to amyloid-beta
A1905039biological_processcarboxylic acid transmembrane transport
A1990962biological_processxenobiotic transport across blood-brain barrier
B0000166molecular_functionnucleotide binding
B0001894biological_processtissue homeostasis
B0002432biological_processgranuloma formation
B0002437biological_processinflammatory response to antigenic stimulus
B0003158biological_processendothelium development
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0006691biological_processleukotriene metabolic process
B0006749biological_processglutathione metabolic process
B0006805biological_processxenobiotic metabolic process
B0006869biological_processlipid transport
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0006979biological_processresponse to oxidative stress
B0007613biological_processmemory
B0008211biological_processglucocorticoid metabolic process
B0008559molecular_functionABC-type xenobiotic transporter activity
B0009410biological_processresponse to xenobiotic stimulus
B0009636biological_processresponse to toxic substance
B0009925cellular_componentbasal plasma membrane
B0010467biological_processgene expression
B0015127molecular_functionbilirubin transmembrane transporter activity
B0015420molecular_functionABC-type vitamin B12 transporter activity
B0015431molecular_functionABC-type glutathione S-conjugate transporter activity
B0015562molecular_functionefflux transmembrane transporter activity
B0015723biological_processbilirubin transport
B0015889biological_processcobalamin transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016328cellular_componentlateral plasma membrane
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0019370biological_processleukotriene biosynthetic process
B0021764biological_processamygdala development
B0021766biological_processhippocampus development
B0022008biological_processneurogenesis
B0022857molecular_functiontransmembrane transporter activity
B0030148biological_processsphingolipid biosynthetic process
B0033284molecular_functionATPase-coupled carboxylic acid transmembrane transporter activity
B0034040molecular_functionATPase-coupled lipid transmembrane transporter activity
B0034341biological_processresponse to type II interferon
B0034394biological_processprotein localization to cell surface
B0034405biological_processresponse to fluid shear stress
B0034599biological_processcellular response to oxidative stress
B0034634molecular_functionglutathione transmembrane transporter activity
B0034775biological_processglutathione transmembrane transport
B0035264biological_processmulticellular organism growth
B0035640biological_processexploration behavior
B0042116biological_processmacrophage activation
B0042167biological_processheme catabolic process
B0042391biological_processregulation of membrane potential
B0042554biological_processsuperoxide anion generation
B0042626molecular_functionATPase-coupled transmembrane transporter activity
B0042908biological_processxenobiotic transport
B0042910molecular_functionxenobiotic transmembrane transporter activity
B0043225molecular_functionATPase-coupled inorganic anion transmembrane transporter activity
B0043476biological_processpigment accumulation
B0045332biological_processphospholipid translocation
B0045454biological_processcell redox homeostasis
B0046624molecular_functionsphingolipid transporter activity
B0046942biological_processcarboxylic acid transport
B0046943molecular_functioncarboxylic acid transmembrane transporter activity
B0048003biological_processantigen processing and presentation of lipid antigen via MHC class Ib
B0050435biological_processamyloid-beta metabolic process
B0050665biological_processhydrogen peroxide biosynthetic process
B0050729biological_processpositive regulation of inflammatory response
B0050830biological_processdefense response to Gram-positive bacterium
B0051132biological_processNK T cell activation
B0051384biological_processresponse to glucocorticoid
B0051649biological_processestablishment of localization in cell
B0055082biological_processintracellular chemical homeostasis
B0055085biological_processtransmembrane transport
B0060326biological_processcell chemotaxis
B0070062cellular_componentextracellular exosome
B0070633biological_processtransepithelial transport
B0070729biological_processcyclic nucleotide transport
B0071346biological_processcellular response to type II interferon
B0071716biological_processleukotriene transport
B0072577biological_processendothelial cell apoptotic process
B0072676biological_processlymphocyte migration
B0097242biological_processamyloid-beta clearance
B0097719biological_processneural tissue regeneration
B0097746biological_processblood vessel diameter maintenance
B0098656biological_processmonoatomic anion transmembrane transport
B0099039biological_processsphingolipid translocation
B0140115biological_processexport across plasma membrane
B0140352biological_processexport from cell
B0140359molecular_functionABC-type transporter activity
B0141067biological_processintracellular nitrogen homeostasis
B0150104biological_processtransport across blood-brain barrier
B1903409biological_processreactive oxygen species biosynthetic process
B1904646biological_processcellular response to amyloid-beta
B1905039biological_processcarboxylic acid transmembrane transport
B1990962biological_processxenobiotic transport across blood-brain barrier
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues26
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGCGKSSLLSaLlaemdkvegh........VAIK
ChainResidueDetails
AVAL680-LYS705

site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRVSLARAV
ChainResidueDetails
ALEU768-VAL782
ALEU1430-LEU1444

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues278
DetailsTopological domain: {"description":"Extracellular"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=1"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues310
DetailsTopological domain: {"description":"Cytoplasmic"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=2"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=3"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=4"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=5"}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=6"}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=7"}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=8"}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=10"}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=11"}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=14"}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=15"}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=16"}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=17"}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues448
DetailsDomain: {"description":"ABC transporter 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues18
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"9295302","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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