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8VUX

Cryo-EM structure of human ABC transporter (hABCC1) bound to cGAMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0006691biological_processleukotriene metabolic process
A0006805biological_processxenobiotic metabolic process
A0006869biological_processlipid transport
A0008559molecular_functionABC-type xenobiotic transporter activity
A0009410biological_processresponse to xenobiotic stimulus
A0009925cellular_componentbasal plasma membrane
A0015420molecular_functionABC-type vitamin B12 transporter activity
A0015431molecular_functionABC-type glutathione S-conjugate transporter activity
A0015562molecular_functionefflux transmembrane transporter activity
A0015889biological_processcobalamin transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016328cellular_componentlateral plasma membrane
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0022857molecular_functiontransmembrane transporter activity
A0030148biological_processsphingolipid biosynthetic process
A0034040molecular_functionATPase-coupled lipid transmembrane transporter activity
A0034599biological_processcellular response to oxidative stress
A0034634molecular_functionglutathione transmembrane transporter activity
A0034775biological_processglutathione transmembrane transport
A0042167biological_processheme catabolic process
A0042626molecular_functionATPase-coupled transmembrane transporter activity
A0042908biological_processxenobiotic transport
A0042910molecular_functionxenobiotic transmembrane transporter activity
A0043225molecular_functionATPase-coupled inorganic anion transmembrane transporter activity
A0045332biological_processphospholipid translocation
A0046624molecular_functionsphingolipid transporter activity
A0046942biological_processcarboxylic acid transport
A0046943molecular_functioncarboxylic acid transmembrane transporter activity
A0050729biological_processpositive regulation of inflammatory response
A0055085biological_processtransmembrane transport
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
A0070633biological_processtransepithelial transport
A0070729biological_processcyclic nucleotide transport
A0071716biological_processleukotriene transport
A0098656biological_processmonoatomic anion transmembrane transport
A0099039biological_processsphingolipid translocation
A0140115biological_processexport across plasma membrane
A0140359molecular_functionABC-type transporter activity
A0150104biological_processtransport across blood-brain barrier
A1904646biological_processcellular response to amyloid-beta
A1905039biological_processcarboxylic acid transmembrane transport
A1990962biological_processxenobiotic transport across blood-brain barrier
B0000166molecular_functionnucleotide binding
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0006691biological_processleukotriene metabolic process
B0006805biological_processxenobiotic metabolic process
B0006869biological_processlipid transport
B0008559molecular_functionABC-type xenobiotic transporter activity
B0009410biological_processresponse to xenobiotic stimulus
B0009925cellular_componentbasal plasma membrane
B0015420molecular_functionABC-type vitamin B12 transporter activity
B0015431molecular_functionABC-type glutathione S-conjugate transporter activity
B0015562molecular_functionefflux transmembrane transporter activity
B0015889biological_processcobalamin transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016328cellular_componentlateral plasma membrane
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0022857molecular_functiontransmembrane transporter activity
B0030148biological_processsphingolipid biosynthetic process
B0034040molecular_functionATPase-coupled lipid transmembrane transporter activity
B0034599biological_processcellular response to oxidative stress
B0034634molecular_functionglutathione transmembrane transporter activity
B0034775biological_processglutathione transmembrane transport
B0042167biological_processheme catabolic process
B0042626molecular_functionATPase-coupled transmembrane transporter activity
B0042908biological_processxenobiotic transport
B0042910molecular_functionxenobiotic transmembrane transporter activity
B0043225molecular_functionATPase-coupled inorganic anion transmembrane transporter activity
B0045332biological_processphospholipid translocation
B0046624molecular_functionsphingolipid transporter activity
B0046942biological_processcarboxylic acid transport
B0046943molecular_functioncarboxylic acid transmembrane transporter activity
B0050729biological_processpositive regulation of inflammatory response
B0055085biological_processtransmembrane transport
B0060326biological_processcell chemotaxis
B0070062cellular_componentextracellular exosome
B0070633biological_processtransepithelial transport
B0070729biological_processcyclic nucleotide transport
B0071716biological_processleukotriene transport
B0098656biological_processmonoatomic anion transmembrane transport
B0099039biological_processsphingolipid translocation
B0140115biological_processexport across plasma membrane
B0140359molecular_functionABC-type transporter activity
B0150104biological_processtransport across blood-brain barrier
B1904646biological_processcellular response to amyloid-beta
B1905039biological_processcarboxylic acid transmembrane transport
B1990962biological_processxenobiotic transport across blood-brain barrier
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues26
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGCGKSSLLSaLlaemdkvegh........VAIK
ChainResidueDetails
AVAL680-LYS705

site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRVSLARAV
ChainResidueDetails
ALEU768-VAL782
ALEU1430-LEU1444

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues278
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
AMET1-PHE33
BMET1-PHE33
BARG96-ILE100
BSER155-ASP172
BMET338-GLY363
BLEU462-PRO464
BVAL569-ASN590
BALA989-SER1025
BALA1111
BLEU1225-SER1226
AARG96-ILE100
ASER155-ASP172
AMET338-GLY363
ALEU462-PRO464
AVAL569-ASN590
AALA989-SER1025
AALA1111
ALEU1225-SER1226

site_idSWS_FT_FI2
Number of Residues40
DetailsTRANSMEM: Helical; Name=1
ChainResidueDetails
AGLN34-PHE54
BGLN34-PHE54

site_idSWS_FT_FI3
Number of Residues2036
DetailsTOPO_DOM: Cytoplasmic
ChainResidueDetails
ALEU55-LYS74
BLEU55-LYS74
BPHE122-GLN133
BARG194-VAL316
BPHE385-TYR440
BLYS486-ALA547
BSER612-MET967
BCYS1047-GLU1089
BTYR1133-LEU1203
BVAL1248-VAL1531
APHE122-GLN133
AARG194-VAL316
APHE385-TYR440
ALYS486-ALA547
ASER612-MET967
ACYS1047-GLU1089
ATYR1133-LEU1203
AVAL1248-VAL1531

site_idSWS_FT_FI4
Number of Residues40
DetailsTRANSMEM: Helical; Name=2
ChainResidueDetails
ATHR75-GLU95
BTHR75-GLU95

site_idSWS_FT_FI5
Number of Residues40
DetailsTRANSMEM: Helical; Name=3
ChainResidueDetails
APHE101-THR121
BPHE101-THR121

site_idSWS_FT_FI6
Number of Residues40
DetailsTRANSMEM: Helical; Name=4
ChainResidueDetails
ASER134-ARG154
BSER134-ARG154

site_idSWS_FT_FI7
Number of Residues40
DetailsTRANSMEM: Helical; Name=5
ChainResidueDetails
AILE173-ASP193
BILE173-ASP193

site_idSWS_FT_FI8
Number of Residues40
DetailsTRANSMEM: Helical; Name=6
ChainResidueDetails
ALEU317-LEU337
BLEU317-LEU337

site_idSWS_FT_FI9
Number of Residues40
DetailsTRANSMEM: Helical; Name=7
ChainResidueDetails
ATYR364-TYR384
BTYR364-TYR384

site_idSWS_FT_FI10
Number of Residues40
DetailsTRANSMEM: Helical; Name=8
ChainResidueDetails
AILE441-ASN461
BILE441-ASN461

site_idSWS_FT_FI11
Number of Residues40
DetailsTRANSMEM: Helical; Name=9
ChainResidueDetails
ASER465-MET485
BSER465-MET485

site_idSWS_FT_FI12
Number of Residues40
DetailsTRANSMEM: Helical; Name=10
ChainResidueDetails
AVAL548-TYR568
BVAL548-TYR568

site_idSWS_FT_FI13
Number of Residues40
DetailsTRANSMEM: Helical; Name=11
ChainResidueDetails
AILE591-VAL611
BILE591-VAL611

site_idSWS_FT_FI14
Number of Residues40
DetailsTRANSMEM: Helical; Name=12
ChainResidueDetails
ALYS968-SER988
BLYS968-SER988

site_idSWS_FT_FI15
Number of Residues40
DetailsTRANSMEM: Helical; Name=13
ChainResidueDetails
AGLN1026-ARG1046
BGLN1026-ARG1046

site_idSWS_FT_FI16
Number of Residues40
DetailsTRANSMEM: Helical; Name=14
ChainResidueDetails
AVAL1090-LEU1110
BVAL1090-LEU1110

site_idSWS_FT_FI17
Number of Residues40
DetailsTRANSMEM: Helical; Name=15
ChainResidueDetails
ATHR1112-PHE1132
BTHR1112-PHE1132

site_idSWS_FT_FI18
Number of Residues40
DetailsTRANSMEM: Helical; Name=16
ChainResidueDetails
AGLU1204-SER1224
BGLU1204-SER1224

site_idSWS_FT_FI19
Number of Residues40
DetailsTRANSMEM: Helical; Name=17
ChainResidueDetails
AALA1227-LEU1247
BALA1227-LEU1247

site_idSWS_FT_FI20
Number of Residues6
DetailsBINDING:
ChainResidueDetails
ATRP653
AGLY678
AGLN713
BTRP653
BGLY678
BGLN713

site_idSWS_FT_FI21
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
ChainResidueDetails
AGLY1327
BGLY1327

site_idSWS_FT_FI22
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:O35379
ChainResidueDetails
ATYR277
BTYR277

site_idSWS_FT_FI23
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O35379
ChainResidueDetails
ASER289
BSER289

site_idSWS_FT_FI24
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:O35379
ChainResidueDetails
ALYS503
BLYS503

site_idSWS_FT_FI25
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER905
BSER905

site_idSWS_FT_FI26
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER915
BSER915

site_idSWS_FT_FI27
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692
ChainResidueDetails
ASER930
BSER930

site_idSWS_FT_FI28
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:9295302
ChainResidueDetails
AASN19
AASN23
AASN1006
BASN19
BASN23
BASN1006

237735

PDB entries from 2025-06-18

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