Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8VKH

Structure of gelsolin domains G1G3 bound to the barbed end of F-actin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001725	cellular_component	stress fiber
A	0003785	molecular_function	actin monomer binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005523	molecular_function	tropomyosin binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005865	cellular_component	striated muscle thin filament
A	0005884	cellular_component	actin filament
A	0010628	biological_process	positive regulation of gene expression
A	0016787	molecular_function	hydrolase activity
A	0019904	molecular_function	protein domain specific binding
A	0030027	cellular_component	lamellipodium
A	0030041	biological_process	actin filament polymerization
A	0030175	cellular_component	filopodium
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0031013	molecular_function	troponin I binding
A	0031432	molecular_function	titin binding
A	0031941	cellular_component	filamentous actin
A	0032036	molecular_function	myosin heavy chain binding
A	0032432	cellular_component	actin filament bundle
A	0042802	molecular_function	identical protein binding
A	0044297	cellular_component	cell body
A	0048306	molecular_function	calcium-dependent protein binding
A	0048741	biological_process	skeletal muscle fiber development
A	0051017	biological_process	actin filament bundle assembly
A	0090131	biological_process	mesenchyme migration
A	0098723	cellular_component	skeletal muscle myofibril
A	0140660	molecular_function	cytoskeletal motor activator activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0001725	cellular_component	stress fiber
B	0003785	molecular_function	actin monomer binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005523	molecular_function	tropomyosin binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005865	cellular_component	striated muscle thin filament
B	0005884	cellular_component	actin filament
B	0010628	biological_process	positive regulation of gene expression
B	0016787	molecular_function	hydrolase activity
B	0019904	molecular_function	protein domain specific binding
B	0030027	cellular_component	lamellipodium
B	0030041	biological_process	actin filament polymerization
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0031013	molecular_function	troponin I binding
B	0031432	molecular_function	titin binding
B	0031941	cellular_component	filamentous actin
B	0032036	molecular_function	myosin heavy chain binding
B	0032432	cellular_component	actin filament bundle
B	0042802	molecular_function	identical protein binding
B	0044297	cellular_component	cell body
B	0048306	molecular_function	calcium-dependent protein binding
B	0048741	biological_process	skeletal muscle fiber development
B	0051017	biological_process	actin filament bundle assembly
B	0090131	biological_process	mesenchyme migration
B	0098723	cellular_component	skeletal muscle myofibril
B	0140660	molecular_function	cytoskeletal motor activator activity
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0001725	cellular_component	stress fiber
C	0003785	molecular_function	actin monomer binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005523	molecular_function	tropomyosin binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005865	cellular_component	striated muscle thin filament
C	0005884	cellular_component	actin filament
C	0010628	biological_process	positive regulation of gene expression
C	0016787	molecular_function	hydrolase activity
C	0019904	molecular_function	protein domain specific binding
C	0030027	cellular_component	lamellipodium
C	0030041	biological_process	actin filament polymerization
C	0030175	cellular_component	filopodium
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0031013	molecular_function	troponin I binding
C	0031432	molecular_function	titin binding
C	0031941	cellular_component	filamentous actin
C	0032036	molecular_function	myosin heavy chain binding
C	0032432	cellular_component	actin filament bundle
C	0042802	molecular_function	identical protein binding
C	0044297	cellular_component	cell body
C	0048306	molecular_function	calcium-dependent protein binding
C	0048741	biological_process	skeletal muscle fiber development
C	0051017	biological_process	actin filament bundle assembly
C	0090131	biological_process	mesenchyme migration
C	0098723	cellular_component	skeletal muscle myofibril
C	0140660	molecular_function	cytoskeletal motor activator activity
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0001725	cellular_component	stress fiber
D	0003785	molecular_function	actin monomer binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005523	molecular_function	tropomyosin binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005865	cellular_component	striated muscle thin filament
D	0005884	cellular_component	actin filament
D	0010628	biological_process	positive regulation of gene expression
D	0016787	molecular_function	hydrolase activity
D	0019904	molecular_function	protein domain specific binding
D	0030027	cellular_component	lamellipodium
D	0030041	biological_process	actin filament polymerization
D	0030175	cellular_component	filopodium
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0031013	molecular_function	troponin I binding
D	0031432	molecular_function	titin binding
D	0031941	cellular_component	filamentous actin
D	0032036	molecular_function	myosin heavy chain binding
D	0032432	cellular_component	actin filament bundle
D	0042802	molecular_function	identical protein binding
D	0044297	cellular_component	cell body
D	0048306	molecular_function	calcium-dependent protein binding
D	0048741	biological_process	skeletal muscle fiber development
D	0051017	biological_process	actin filament bundle assembly
D	0090131	biological_process	mesenchyme migration
D	0098723	cellular_component	skeletal muscle myofibril
D	0140660	molecular_function	cytoskeletal motor activator activity
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0001725	cellular_component	stress fiber
E	0003785	molecular_function	actin monomer binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005523	molecular_function	tropomyosin binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005865	cellular_component	striated muscle thin filament
E	0005884	cellular_component	actin filament
E	0010628	biological_process	positive regulation of gene expression
E	0016787	molecular_function	hydrolase activity
E	0019904	molecular_function	protein domain specific binding
E	0030027	cellular_component	lamellipodium
E	0030041	biological_process	actin filament polymerization
E	0030175	cellular_component	filopodium
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0031013	molecular_function	troponin I binding
E	0031432	molecular_function	titin binding
E	0031941	cellular_component	filamentous actin
E	0032036	molecular_function	myosin heavy chain binding
E	0032432	cellular_component	actin filament bundle
E	0042802	molecular_function	identical protein binding
E	0044297	cellular_component	cell body
E	0048306	molecular_function	calcium-dependent protein binding
E	0048741	biological_process	skeletal muscle fiber development
E	0051017	biological_process	actin filament bundle assembly
E	0090131	biological_process	mesenchyme migration
E	0098723	cellular_component	skeletal muscle myofibril
E	0140660	molecular_function	cytoskeletal motor activator activity
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0001725	cellular_component	stress fiber
F	0003785	molecular_function	actin monomer binding
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005523	molecular_function	tropomyosin binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005865	cellular_component	striated muscle thin filament
F	0005884	cellular_component	actin filament
F	0010628	biological_process	positive regulation of gene expression
F	0016787	molecular_function	hydrolase activity
F	0019904	molecular_function	protein domain specific binding
F	0030027	cellular_component	lamellipodium
F	0030041	biological_process	actin filament polymerization
F	0030175	cellular_component	filopodium
F	0030240	biological_process	skeletal muscle thin filament assembly
F	0031013	molecular_function	troponin I binding
F	0031432	molecular_function	titin binding
F	0031941	cellular_component	filamentous actin
F	0032036	molecular_function	myosin heavy chain binding
F	0032432	cellular_component	actin filament bundle
F	0042802	molecular_function	identical protein binding
F	0044297	cellular_component	cell body
F	0048306	molecular_function	calcium-dependent protein binding
F	0048741	biological_process	skeletal muscle fiber development
F	0051017	biological_process	actin filament bundle assembly
F	0090131	biological_process	mesenchyme migration
F	0098723	cellular_component	skeletal muscle myofibril
F	0140660	molecular_function	cytoskeletal motor activator activity
G	0002102	cellular_component	podosome
G	0003779	molecular_function	actin binding
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0006911	biological_process	phagocytosis, engulfment
G	0007015	biological_process	actin filament organization
G	0007417	biological_process	central nervous system development
G	0008154	biological_process	actin polymerization or depolymerization
G	0010628	biological_process	positive regulation of gene expression
G	0014891	biological_process	striated muscle atrophy
G	0015629	cellular_component	actin cytoskeleton
G	0016192	biological_process	vesicle-mediated transport
G	0016528	cellular_component	sarcoplasm
G	0022617	biological_process	extracellular matrix disassembly
G	0030027	cellular_component	lamellipodium
G	0030030	biological_process	cell projection organization
G	0030031	biological_process	cell projection assembly
G	0030036	biological_process	actin cytoskeleton organization
G	0030041	biological_process	actin filament polymerization
G	0030042	biological_process	actin filament depolymerization
G	0030478	cellular_component	actin cap
G	0030864	cellular_component	cortical actin cytoskeleton
G	0031648	biological_process	protein destabilization
G	0034774	cellular_component	secretory granule lumen
G	0035994	biological_process	response to muscle stretch
G	0036313	molecular_function	phosphatidylinositol 3-kinase catalytic subunit binding
G	0043065	biological_process	positive regulation of apoptotic process
G	0045159	molecular_function	myosin II binding
G	0045335	cellular_component	phagocytic vesicle
G	0046597	biological_process	host-mediated suppression of symbiont invasion
G	0046872	molecular_function	metal ion binding
G	0051014	biological_process	actin filament severing
G	0051015	molecular_function	actin filament binding
G	0051016	biological_process	barbed-end actin filament capping
G	0051127	biological_process	positive regulation of actin nucleation
G	0051693	biological_process	actin filament capping
G	0055119	biological_process	relaxation of cardiac muscle
G	0060271	biological_process	cilium assembly
G	0070062	cellular_component	extracellular exosome
G	0071346	biological_process	cellular response to type II interferon
G	0071801	biological_process	regulation of podosome assembly
G	0072562	cellular_component	blood microparticle
G	0086003	biological_process	cardiac muscle cell contraction
G	0097017	biological_process	renal protein absorption
G	0097284	biological_process	hepatocyte apoptotic process
G	1902174	biological_process	positive regulation of keratinocyte apoptotic process
G	1903903	biological_process	regulation of establishment of T cell polarity
G	1903906	biological_process	regulation of plasma membrane raft polarization
G	1903909	biological_process	regulation of receptor clustering
G	1903923	biological_process	positive regulation of protein processing in phagocytic vesicle
G	1904813	cellular_component	ficolin-1-rich granule lumen
G	1990000	biological_process	amyloid fibril formation
H	0002102	cellular_component	podosome
H	0003779	molecular_function	actin binding
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0006911	biological_process	phagocytosis, engulfment
H	0007015	biological_process	actin filament organization
H	0007417	biological_process	central nervous system development
H	0008154	biological_process	actin polymerization or depolymerization
H	0010628	biological_process	positive regulation of gene expression
H	0014891	biological_process	striated muscle atrophy
H	0015629	cellular_component	actin cytoskeleton
H	0016192	biological_process	vesicle-mediated transport
H	0016528	cellular_component	sarcoplasm
H	0022617	biological_process	extracellular matrix disassembly
H	0030027	cellular_component	lamellipodium
H	0030030	biological_process	cell projection organization
H	0030031	biological_process	cell projection assembly
H	0030036	biological_process	actin cytoskeleton organization
H	0030041	biological_process	actin filament polymerization
H	0030042	biological_process	actin filament depolymerization
H	0030478	cellular_component	actin cap
H	0030864	cellular_component	cortical actin cytoskeleton
H	0031648	biological_process	protein destabilization
H	0034774	cellular_component	secretory granule lumen
H	0035994	biological_process	response to muscle stretch
H	0036313	molecular_function	phosphatidylinositol 3-kinase catalytic subunit binding
H	0043065	biological_process	positive regulation of apoptotic process
H	0045159	molecular_function	myosin II binding
H	0045335	cellular_component	phagocytic vesicle
H	0046597	biological_process	host-mediated suppression of symbiont invasion
H	0046872	molecular_function	metal ion binding
H	0051014	biological_process	actin filament severing
H	0051015	molecular_function	actin filament binding
H	0051016	biological_process	barbed-end actin filament capping
H	0051127	biological_process	positive regulation of actin nucleation
H	0051693	biological_process	actin filament capping
H	0055119	biological_process	relaxation of cardiac muscle
H	0060271	biological_process	cilium assembly
H	0070062	cellular_component	extracellular exosome
H	0071346	biological_process	cellular response to type II interferon
H	0071801	biological_process	regulation of podosome assembly
H	0072562	cellular_component	blood microparticle
H	0086003	biological_process	cardiac muscle cell contraction
H	0097017	biological_process	renal protein absorption
H	0097284	biological_process	hepatocyte apoptotic process
H	1902174	biological_process	positive regulation of keratinocyte apoptotic process
H	1903903	biological_process	regulation of establishment of T cell polarity
H	1903906	biological_process	regulation of plasma membrane raft polarization
H	1903909	biological_process	regulation of receptor clustering
H	1903923	biological_process	positive regulation of protein processing in phagocytic vesicle
H	1904813	cellular_component	ficolin-1-rich granule lumen
H	1990000	biological_process	amyloid fibril formation

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
A	TRP356-GLU364

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU104-ARG116

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	BINDING: BINDING => ECO:0000269\|PubMed:19666512, ECO:0007744\|PDB:3FFK

Chain	Residue	Details
G	GLY65
G	GLU209
G	ASP259
G	GLU302
G	ASP303
G	GLU327
H	GLY65
H	ASP66
H	GLU97
H	ASP109
H	GLY114
G	ASP66
H	ALA116
H	VAL145
H	GLY186
H	ASP187
H	GLU209
H	ASP259
H	GLU302
H	ASP303
H	GLU327
G	GLU97
G	ASP109
G	GLY114
G	ALA116
G	VAL145
G	GLY186
G	ASP187

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
G	LYS135
E	MET47
F	MET44
F	MET47
G	ARG161
H	LYS135
H	ARG161
C	MET44
C	MET47
D	MET44
D	MET47
E	MET44

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:12460571, ECO:0000269\|PubMed:16466744, ECO:0007744\|PDB:1H1V, ECO:0007744\|PDB:2FH2, ECO:0007744\|PDB:2FH3

Chain	Residue	Details
G	GLY444
G	GLU587
H	GLY444
H	GLU587
E	LYS61
F	LYS61

site_id	SWS_FT_FI4
Number of Residues	14
Details	BINDING: BINDING => ECO:0000269\|PubMed:12460571, ECO:0000269\|PubMed:16466744, ECO:0007744\|PDB:1H1V, ECO:0007744\|PDB:2FH1, ECO:0007744\|PDB:2FH2, ECO:0007744\|PDB:2FH3

Chain	Residue	Details
G	ASP445
H	THR524
H	ASN564
H	ASP565
H	ASP669
H	GLU692
G	GLU475
G	THR524
G	ASN564
G	ASP565
G	ASP669
G	GLU692
H	ASP445
H	GLU475

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:12460571, ECO:0007744\|PDB:1H1V

Chain	Residue	Details
G	ASP487
G	GLY492
G	PRO494
H	ASP487
H	GLY492
H	PRO494

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:12460571, ECO:0000269\|PubMed:16466744, ECO:0007744\|PDB:1H1V, ECO:0007744\|PDB:2FH3

Chain	Residue	Details
G	ASP670
H	ASP670
C	ARG177
D	ARG177
E	ARG177
F	ARG177

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: Phosphotyrosine; by SRC; in vitro => ECO:0000269\|PubMed:10210201

Chain	Residue	Details
G	TYR59
G	TYR382
G	TYR576
G	TYR624
H	TYR59
H	TYR382
H	TYR576
H	TYR624

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by SRC => ECO:0000269\|PubMed:10210201

Chain	Residue	Details
G	TYR438
H	TYR438

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P13020

Chain	Residue	Details
G	LYS557
H	LYS557

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
G	THR715
H	THR715

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)