8VGO

CryoEM structure of CD20 in complex with engineered conformationally rigid Rituximab.4DS Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0016020	cellular_component	membrane
I	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
B	TYR192-HIS198
A	TYR199-HIS205

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	162
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
G	ILE57-ALA78
G	TRP85-GLU105
G	SER121-ILE141
G	LEU189-ALA209
I	ILE57-ALA78
I	TRP85-GLU105
I	SER121-ILE141
I	LEU189-ALA209

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site_id	SWS_FT_FI2
Number of Residues	102
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
G	PRO79-VAL84
G	LYS142-SER188
I	PRO79-VAL84
I	LYS142-SER188

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site_id	SWS_FT_FI3
Number of Residues	202
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
G	LYS106-ASN120
G	GLY210-PRO297
I	LYS106-ASN120
I	GLY210-PRO297

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P19437

Chain	Residue	Details
G	SER225
I	SER225

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P19437

Chain	Residue	Details
G	THR239
I	THR239

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site_id	SWS_FT_FI6
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000305|PubMed:22615937

Chain	Residue	Details
G	CYS111
I	CYS111

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site_id	SWS_FT_FI7
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:22615937

Chain	Residue	Details
G	CYS220
I	CYS220

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