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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8VC3

Voltage gated potassium ion channel Kv1.2 in complex with DTx

Functional Information from GO Data
ChainGOidnamespacecontents
A0004867molecular_functionserine-type endopeptidase inhibitor activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0015459molecular_functionpotassium channel regulator activity
A0035821biological_processmodulation of process of another organism
A0090729molecular_functiontoxin activity
A0099106molecular_functionion channel regulator activity
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005251molecular_functiondelayed rectifier potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005768cellular_componentendosome
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0008076cellular_componentvoltage-gated potassium channel complex
B0014059biological_processregulation of dopamine secretion
B0015271molecular_functionoutward rectifier potassium channel activity
B0016020cellular_componentmembrane
B0019228biological_processneuronal action potential
B0019233biological_processsensory perception of pain
B0019894molecular_functionkinesin binding
B0021554biological_processoptic nerve development
B0021633biological_processoptic nerve structural organization
B0021987biological_processcerebral cortex development
B0022038biological_processcorpus callosum development
B0030027cellular_componentlamellipodium
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0031258cellular_componentlamellipodium membrane
B0032809cellular_componentneuronal cell body membrane
B0033010cellular_componentparanodal junction
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0034705cellular_componentpotassium channel complex
B0042734cellular_componentpresynaptic membrane
B0043005cellular_componentneuron projection
B0043194cellular_componentaxon initial segment
B0043204cellular_componentperikaryon
B0043679cellular_componentaxon terminus
B0044224cellular_componentjuxtaparanode region of axon
B0044305cellular_componentcalyx of Held
B0045188biological_processregulation of circadian sleep/wake cycle, non-REM sleep
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0051260biological_processprotein homooligomerization
B0055085biological_processtransmembrane transport
B0060078biological_processregulation of postsynaptic membrane potential
B0071805biological_processpotassium ion transmembrane transport
B0097623biological_processpotassium ion export across plasma membrane
B0098978cellular_componentglutamatergic synapse
B0099505biological_processregulation of presynaptic membrane potential
B0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C0001508biological_processaction potential
C0005216molecular_functionmonoatomic ion channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005251molecular_functiondelayed rectifier potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005768cellular_componentendosome
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0008076cellular_componentvoltage-gated potassium channel complex
C0014059biological_processregulation of dopamine secretion
C0015271molecular_functionoutward rectifier potassium channel activity
C0016020cellular_componentmembrane
C0019228biological_processneuronal action potential
C0019233biological_processsensory perception of pain
C0019894molecular_functionkinesin binding
C0021554biological_processoptic nerve development
C0021633biological_processoptic nerve structural organization
C0021987biological_processcerebral cortex development
C0022038biological_processcorpus callosum development
C0030027cellular_componentlamellipodium
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0031258cellular_componentlamellipodium membrane
C0032809cellular_componentneuronal cell body membrane
C0033010cellular_componentparanodal junction
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0034705cellular_componentpotassium channel complex
C0042734cellular_componentpresynaptic membrane
C0043005cellular_componentneuron projection
C0043194cellular_componentaxon initial segment
C0043204cellular_componentperikaryon
C0043679cellular_componentaxon terminus
C0044224cellular_componentjuxtaparanode region of axon
C0044305cellular_componentcalyx of Held
C0045188biological_processregulation of circadian sleep/wake cycle, non-REM sleep
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0051260biological_processprotein homooligomerization
C0055085biological_processtransmembrane transport
C0060078biological_processregulation of postsynaptic membrane potential
C0071805biological_processpotassium ion transmembrane transport
C0097623biological_processpotassium ion export across plasma membrane
C0098978cellular_componentglutamatergic synapse
C0099505biological_processregulation of presynaptic membrane potential
C0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D0001508biological_processaction potential
D0005216molecular_functionmonoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005251molecular_functiondelayed rectifier potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005768cellular_componentendosome
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0008076cellular_componentvoltage-gated potassium channel complex
D0014059biological_processregulation of dopamine secretion
D0015271molecular_functionoutward rectifier potassium channel activity
D0016020cellular_componentmembrane
D0019228biological_processneuronal action potential
D0019233biological_processsensory perception of pain
D0019894molecular_functionkinesin binding
D0021554biological_processoptic nerve development
D0021633biological_processoptic nerve structural organization
D0021987biological_processcerebral cortex development
D0022038biological_processcorpus callosum development
D0030027cellular_componentlamellipodium
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0031258cellular_componentlamellipodium membrane
D0032809cellular_componentneuronal cell body membrane
D0033010cellular_componentparanodal junction
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0034705cellular_componentpotassium channel complex
D0042734cellular_componentpresynaptic membrane
D0043005cellular_componentneuron projection
D0043194cellular_componentaxon initial segment
D0043204cellular_componentperikaryon
D0043679cellular_componentaxon terminus
D0044224cellular_componentjuxtaparanode region of axon
D0044305cellular_componentcalyx of Held
D0045188biological_processregulation of circadian sleep/wake cycle, non-REM sleep
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0051260biological_processprotein homooligomerization
D0055085biological_processtransmembrane transport
D0060078biological_processregulation of postsynaptic membrane potential
D0071805biological_processpotassium ion transmembrane transport
D0097623biological_processpotassium ion export across plasma membrane
D0098978cellular_componentglutamatergic synapse
D0099505biological_processregulation of presynaptic membrane potential
D0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E0001508biological_processaction potential
E0005216molecular_functionmonoatomic ion channel activity
E0005249molecular_functionvoltage-gated potassium channel activity
E0005251molecular_functiondelayed rectifier potassium channel activity
E0005267molecular_functionpotassium channel activity
E0005515molecular_functionprotein binding
E0005768cellular_componentendosome
E0005789cellular_componentendoplasmic reticulum membrane
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006813biological_processpotassium ion transport
E0008076cellular_componentvoltage-gated potassium channel complex
E0014059biological_processregulation of dopamine secretion
E0015271molecular_functionoutward rectifier potassium channel activity
E0016020cellular_componentmembrane
E0019228biological_processneuronal action potential
E0019233biological_processsensory perception of pain
E0019894molecular_functionkinesin binding
E0021554biological_processoptic nerve development
E0021633biological_processoptic nerve structural organization
E0021987biological_processcerebral cortex development
E0022038biological_processcorpus callosum development
E0030027cellular_componentlamellipodium
E0030424cellular_componentaxon
E0030425cellular_componentdendrite
E0031258cellular_componentlamellipodium membrane
E0032809cellular_componentneuronal cell body membrane
E0033010cellular_componentparanodal junction
E0034220biological_processmonoatomic ion transmembrane transport
E0034702cellular_componentmonoatomic ion channel complex
E0034705cellular_componentpotassium channel complex
E0042734cellular_componentpresynaptic membrane
E0043005cellular_componentneuron projection
E0043194cellular_componentaxon initial segment
E0043204cellular_componentperikaryon
E0043679cellular_componentaxon terminus
E0044224cellular_componentjuxtaparanode region of axon
E0044305cellular_componentcalyx of Held
E0045188biological_processregulation of circadian sleep/wake cycle, non-REM sleep
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0051260biological_processprotein homooligomerization
E0055085biological_processtransmembrane transport
E0060078biological_processregulation of postsynaptic membrane potential
E0071805biological_processpotassium ion transmembrane transport
E0097623biological_processpotassium ion export across plasma membrane
E0098978cellular_componentglutamatergic synapse
E0099505biological_processregulation of presynaptic membrane potential
E0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
E1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Functional Information from PROSITE/UniProt
site_idPS00280
Number of Residues19
DetailsBPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FdwSGCggnsnrFktieeC
ChainResidueDetails
APHE35-CYS53
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues50
DetailsDomain: {"description":"BPTI/Kunitz inhibitor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00031","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsSite: {"description":"May be the major determinant of the binding affinity for potassium channels"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsSite: {"description":"Important for binding to potassium channels"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsSite: {"description":"Not important for inhibition of potassium channels"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues96
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues76
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues44
DetailsIntramembrane: {"description":"Helical; Name=Pore helix","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues28
DetailsIntramembrane: {"evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues112
DetailsTransmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues52
DetailsRegion: {"description":"S4-S5 linker","evidences":[{"source":"PubMed","id":"16002579","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues20
DetailsMotif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsSite: {"description":"Important for normal, slow channel gating","evidences":[{"source":"PubMed","id":"17766348","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsSite: {"description":"Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxin","evidences":[{"source":"PubMed","id":"25514171","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16770729","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

244349

PDB entries from 2025-11-05

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