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8VC3

Voltage gated potassium ion channel Kv1.2 in complex with DTx

Functional Information from GO Data
ChainGOidnamespacecontents
A0004867molecular_functionserine-type endopeptidase inhibitor activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0015459molecular_functionpotassium channel regulator activity
A0030414molecular_functionpeptidase inhibitor activity
A0035821biological_processmodulation of process of another organism
A0090729molecular_functiontoxin activity
B0001508biological_processaction potential
B0005249molecular_functionvoltage-gated potassium channel activity
B0005251molecular_functiondelayed rectifier potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005768cellular_componentendosome
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0008076cellular_componentvoltage-gated potassium channel complex
B0014059biological_processregulation of dopamine secretion
B0015271molecular_functionoutward rectifier potassium channel activity
B0016020cellular_componentmembrane
B0019228biological_processneuronal action potential
B0019233biological_processsensory perception of pain
B0019894molecular_functionkinesin binding
B0021554biological_processoptic nerve development
B0021633biological_processoptic nerve structural organization
B0021987biological_processcerebral cortex development
B0022038biological_processcorpus callosum development
B0030027cellular_componentlamellipodium
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0031258cellular_componentlamellipodium membrane
B0032809cellular_componentneuronal cell body membrane
B0033010cellular_componentparanodal junction
B0034702cellular_componentmonoatomic ion channel complex
B0034705cellular_componentpotassium channel complex
B0042734cellular_componentpresynaptic membrane
B0043005cellular_componentneuron projection
B0043194cellular_componentaxon initial segment
B0043204cellular_componentperikaryon
B0043679cellular_componentaxon terminus
B0044224cellular_componentjuxtaparanode region of axon
B0044305cellular_componentcalyx of Held
B0045188biological_processregulation of circadian sleep/wake cycle, non-REM sleep
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0060078biological_processregulation of postsynaptic membrane potential
B0070161cellular_componentanchoring junction
B0071805biological_processpotassium ion transmembrane transport
B0097623biological_processpotassium ion export across plasma membrane
B0098978cellular_componentglutamatergic synapse
B0099505biological_processregulation of presynaptic membrane potential
B0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C0001508biological_processaction potential
C0005249molecular_functionvoltage-gated potassium channel activity
C0005251molecular_functiondelayed rectifier potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005768cellular_componentendosome
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0008076cellular_componentvoltage-gated potassium channel complex
C0014059biological_processregulation of dopamine secretion
C0015271molecular_functionoutward rectifier potassium channel activity
C0016020cellular_componentmembrane
C0019228biological_processneuronal action potential
C0019233biological_processsensory perception of pain
C0019894molecular_functionkinesin binding
C0021554biological_processoptic nerve development
C0021633biological_processoptic nerve structural organization
C0021987biological_processcerebral cortex development
C0022038biological_processcorpus callosum development
C0030027cellular_componentlamellipodium
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0031258cellular_componentlamellipodium membrane
C0032809cellular_componentneuronal cell body membrane
C0033010cellular_componentparanodal junction
C0034702cellular_componentmonoatomic ion channel complex
C0034705cellular_componentpotassium channel complex
C0042734cellular_componentpresynaptic membrane
C0043005cellular_componentneuron projection
C0043194cellular_componentaxon initial segment
C0043204cellular_componentperikaryon
C0043679cellular_componentaxon terminus
C0044224cellular_componentjuxtaparanode region of axon
C0044305cellular_componentcalyx of Held
C0045188biological_processregulation of circadian sleep/wake cycle, non-REM sleep
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0060078biological_processregulation of postsynaptic membrane potential
C0070161cellular_componentanchoring junction
C0071805biological_processpotassium ion transmembrane transport
C0097623biological_processpotassium ion export across plasma membrane
C0098978cellular_componentglutamatergic synapse
C0099505biological_processregulation of presynaptic membrane potential
C0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D0001508biological_processaction potential
D0005249molecular_functionvoltage-gated potassium channel activity
D0005251molecular_functiondelayed rectifier potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005768cellular_componentendosome
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0008076cellular_componentvoltage-gated potassium channel complex
D0014059biological_processregulation of dopamine secretion
D0015271molecular_functionoutward rectifier potassium channel activity
D0016020cellular_componentmembrane
D0019228biological_processneuronal action potential
D0019233biological_processsensory perception of pain
D0019894molecular_functionkinesin binding
D0021554biological_processoptic nerve development
D0021633biological_processoptic nerve structural organization
D0021987biological_processcerebral cortex development
D0022038biological_processcorpus callosum development
D0030027cellular_componentlamellipodium
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0031258cellular_componentlamellipodium membrane
D0032809cellular_componentneuronal cell body membrane
D0033010cellular_componentparanodal junction
D0034702cellular_componentmonoatomic ion channel complex
D0034705cellular_componentpotassium channel complex
D0042734cellular_componentpresynaptic membrane
D0043005cellular_componentneuron projection
D0043194cellular_componentaxon initial segment
D0043204cellular_componentperikaryon
D0043679cellular_componentaxon terminus
D0044224cellular_componentjuxtaparanode region of axon
D0044305cellular_componentcalyx of Held
D0045188biological_processregulation of circadian sleep/wake cycle, non-REM sleep
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0060078biological_processregulation of postsynaptic membrane potential
D0070161cellular_componentanchoring junction
D0071805biological_processpotassium ion transmembrane transport
D0097623biological_processpotassium ion export across plasma membrane
D0098978cellular_componentglutamatergic synapse
D0099505biological_processregulation of presynaptic membrane potential
D0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E0001508biological_processaction potential
E0005249molecular_functionvoltage-gated potassium channel activity
E0005251molecular_functiondelayed rectifier potassium channel activity
E0005267molecular_functionpotassium channel activity
E0005515molecular_functionprotein binding
E0005768cellular_componentendosome
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005886cellular_componentplasma membrane
E0008076cellular_componentvoltage-gated potassium channel complex
E0014059biological_processregulation of dopamine secretion
E0015271molecular_functionoutward rectifier potassium channel activity
E0016020cellular_componentmembrane
E0019228biological_processneuronal action potential
E0019233biological_processsensory perception of pain
E0019894molecular_functionkinesin binding
E0021554biological_processoptic nerve development
E0021633biological_processoptic nerve structural organization
E0021987biological_processcerebral cortex development
E0022038biological_processcorpus callosum development
E0030027cellular_componentlamellipodium
E0030424cellular_componentaxon
E0030425cellular_componentdendrite
E0031258cellular_componentlamellipodium membrane
E0032809cellular_componentneuronal cell body membrane
E0033010cellular_componentparanodal junction
E0034702cellular_componentmonoatomic ion channel complex
E0034705cellular_componentpotassium channel complex
E0042734cellular_componentpresynaptic membrane
E0043005cellular_componentneuron projection
E0043194cellular_componentaxon initial segment
E0043204cellular_componentperikaryon
E0043679cellular_componentaxon terminus
E0044224cellular_componentjuxtaparanode region of axon
E0044305cellular_componentcalyx of Held
E0045188biological_processregulation of circadian sleep/wake cycle, non-REM sleep
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0060078biological_processregulation of postsynaptic membrane potential
E0070161cellular_componentanchoring junction
E0071805biological_processpotassium ion transmembrane transport
E0097623biological_processpotassium ion export across plasma membrane
E0098978cellular_componentglutamatergic synapse
E0099505biological_processregulation of presynaptic membrane potential
E0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
E1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Functional Information from PROSITE/UniProt
site_idPS00280
Number of Residues19
DetailsBPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FdwSGCggnsnrFktieeC
ChainResidueDetails
APHE35-CYS53

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues732
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
EMET1-GLY160
DMET1-GLY160
DCYS244-ILE254
DSER311-MET325
ECYS244-ILE254
ESER311-MET325
BMET1-GLY160
BCYS244-ILE254
BSER311-MET325
CMET1-GLY160
CCYS244-ILE254
CSER311-MET325

site_idSWS_FT_FI2
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
EPRO161-LEU182
BPRO161-LEU182
CPRO161-LEU182
DPRO161-LEU182

site_idSWS_FT_FI3
Number of Residues152
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000305|PubMed:12151401
ChainResidueDetails
EGLU183-PRO221
BGLU183-PRO221
CGLU183-PRO221
DGLU183-PRO221

site_idSWS_FT_FI4
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
EPHE222-ALA243
BPHE222-ALA243
CPHE222-ALA243
DPHE222-ALA243

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20534430
ChainResidueDetails
EMET255-ALA275
BMET255-ALA275
CMET255-ALA275
DMET255-ALA275

site_idSWS_FT_FI6
Number of Residues128
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
EGLU276-SER289
DGLU276-SER289
DPHE348-ILE361
DPRO382-LYS388
EPHE348-ILE361
EPRO382-LYS388
BGLU276-SER289
BPHE348-ILE361
BPRO382-LYS388
CGLU276-SER289
CPHE348-ILE361
CPRO382-LYS388

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20534430
ChainResidueDetails
ELEU290-HIS310
BLEU290-HIS310
CLEU290-HIS310
DLEU290-HIS310

site_idSWS_FT_FI8
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
EARG326-TYR347
BARG326-TYR347
CARG326-TYR347
DARG326-TYR347

site_idSWS_FT_FI9
Number of Residues44
DetailsINTRAMEM: Helical; Name=Pore helix => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
EPRO362-THR373
BPRO362-THR373
CPRO362-THR373
DPRO362-THR373

site_idSWS_FT_FI10
Number of Residues28
DetailsINTRAMEM: INTRAMEM => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
ETHR374-VAL381
BTHR374-VAL381
CTHR374-VAL381
DTHR374-VAL381

site_idSWS_FT_FI11
Number of Residues112
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
EILE389-TYR417
BILE389-TYR417
CILE389-TYR417
DILE389-TYR417

site_idSWS_FT_FI12
Number of Residues324
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:12151401, ECO:0000305
ChainResidueDetails
EHIS418-VAL499
BHIS418-VAL499
CHIS418-VAL499
DHIS418-VAL499

site_idSWS_FT_FI13
Number of Residues4
DetailsSITE: Important for normal, slow channel gating => ECO:0000269|PubMed:17766348
ChainResidueDetails
ETHR252
BTHR252
CTHR252
DTHR252

site_idSWS_FT_FI14
Number of Residues4
DetailsSITE: Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxin => ECO:0000305|PubMed:25514171
ChainResidueDetails
EVAL381
BVAL381
CVAL381
DVAL381

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P63141
ChainResidueDetails
ETYR429
BTYR429
CTYR429
DTYR429

site_idSWS_FT_FI16
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P63141
ChainResidueDetails
ESER434
BSER434
CSER434
DSER434

site_idSWS_FT_FI17
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:18003609, ECO:0007744|PubMed:22673903
ChainResidueDetails
ESER440
BSER440
CSER440
DSER440

site_idSWS_FT_FI18
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ESER441
ESER468
BSER441
BSER468
CSER441
CSER468
DSER441
DSER468

site_idSWS_FT_FI19
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:18003609, ECO:0000269|PubMed:21602278
ChainResidueDetails
ESER449
BSER449
CSER449
DSER449

site_idSWS_FT_FI20
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000305|PubMed:21602278
ChainResidueDetails
ETYR458
BTYR458
CTYR458
DTYR458

site_idSWS_FT_FI21
Number of Residues4
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
ECYS244
BCYS244
CCYS244
DCYS244

site_idSWS_FT_FI22
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:16770729
ChainResidueDetails
EGLN207
BGLN207
CGLN207
DGLN207

225946

PDB entries from 2024-10-09

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