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8V9Q

Crystal structure of mGalNAc-T1 in complex with the mucin glycopeptide Muc5AC-13, Mn2+, and UDP.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004653molecular_functionpolypeptide N-acetylgalactosaminyltransferase activity
A0005576cellular_componentextracellular region
A0005794cellular_componentGolgi apparatus
A0006486biological_processprotein glycosylation
A0006493biological_processprotein O-linked glycosylation
A0016020cellular_componentmembrane
A0016757molecular_functionglycosyltransferase activity
A0018242biological_processprotein O-linked glycosylation via serine
A0018243biological_processprotein O-linked glycosylation via threonine
A0030145molecular_functionmanganese ion binding
A0030246molecular_functioncarbohydrate binding
A0032580cellular_componentGolgi cisterna membrane
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
B0004653molecular_functionpolypeptide N-acetylgalactosaminyltransferase activity
B0005576cellular_componentextracellular region
B0005794cellular_componentGolgi apparatus
B0006486biological_processprotein glycosylation
B0006493biological_processprotein O-linked glycosylation
B0016020cellular_componentmembrane
B0016757molecular_functionglycosyltransferase activity
B0018242biological_processprotein O-linked glycosylation via serine
B0018243biological_processprotein O-linked glycosylation via threonine
B0030145molecular_functionmanganese ion binding
B0030246molecular_functioncarbohydrate binding
B0032580cellular_componentGolgi cisterna membrane
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsCARBOHYD: O-linked (GalNAc) threonine => ECO:0000269|PubMed:25939779, ECO:0007744|PDB:5AJO
ChainResidueDetails
DTHR3
FTHR3
HTHR3

site_idSWS_FT_FI2
Number of Residues3
DetailsCARBOHYD: O-linked (GalNAc) threonine => ECO:0000269|PubMed:25939779, ECO:0007744|PDB:5AJO, ECO:0007744|PDB:5AJP
ChainResidueDetails
DTHR13
FTHR13
HTHR13

site_idSWS_FT_FI3
Number of Residues1060
DetailsTOPO_DOM: Lumenal => ECO:0000255
ChainResidueDetails
ASER29-PHE559
BSER29-PHE559

site_idSWS_FT_FI4
Number of Residues10
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP156
BTYR352
AARG186
ATRP316
AARG347
ATYR352
BASP156
BARG186
BTRP316
BARG347

site_idSWS_FT_FI5
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:15486088
ChainResidueDetails
AASP209
AHIS211
AHIS344
BASP209
BHIS211
BHIS344

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN95
BASN95

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15486088
ChainResidueDetails
AASN552
BASN552

221051

PDB entries from 2024-06-12

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