8V5T
Crystal structure of Alzheimers disease phospholipase D3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0002376 | biological_process | immune system process |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004527 | molecular_function | exonuclease activity |
| A | 0004630 | molecular_function | phospholipase D activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005768 | cellular_component | endosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006954 | biological_process | inflammatory response |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0014902 | biological_process | myotube differentiation |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0031902 | cellular_component | late endosome membrane |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0045145 | molecular_function | single-stranded DNA 5'-3' DNA exonuclease activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1900015 | biological_process | regulation of cytokine production involved in inflammatory response |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0002376 | biological_process | immune system process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004518 | molecular_function | nuclease activity |
| B | 0004527 | molecular_function | exonuclease activity |
| B | 0004630 | molecular_function | phospholipase D activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005764 | cellular_component | lysosome |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005768 | cellular_component | endosome |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006954 | biological_process | inflammatory response |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0012505 | cellular_component | endomembrane system |
| B | 0014902 | biological_process | myotube differentiation |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0031901 | cellular_component | early endosome membrane |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0043202 | cellular_component | lysosomal lumen |
| B | 0045145 | molecular_function | single-stranded DNA 5'-3' DNA exonuclease activity |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1900015 | biological_process | regulation of cytokine production involved in inflammatory response |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 74 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:22428023 |
| Chain | Residue | Details |
| A | MET1-TRP38 | |
| B | MET1-TRP38 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000269|PubMed:22428023 |
| Chain | Residue | Details |
| A | VAL39-LEU59 | |
| B | VAL39-LEU59 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 860 |
| Details | TOPO_DOM: Lumenal => ECO:0000305|PubMed:22428023 |
| Chain | Residue | Details |
| A | TRP60-LEU490 | |
| B | TRP60-LEU490 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU00153 |
| Chain | Residue | Details |
| A | HIS201 | |
| B | HIS201 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00153 |
| Chain | Residue | Details |
| A | LYS203 | |
| A | ASP208 | |
| B | LYS203 | |
| B | ASP208 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:O35405 |
| Chain | Residue | Details |
| A | HIS416 | |
| B | HIS416 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:O35405 |
| Chain | Residue | Details |
| A | HIS201 | |
| A | LYS203 | |
| A | ASN218 | |
| A | HIS416 | |
| B | HIS201 | |
| B | LYS203 | |
| B | ASN218 | |
| B | HIS416 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37994783, ECO:0007744|PDB:8Q1X |
| Chain | Residue | Details |
| A | PHE438 | |
| B | PHE438 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by lysosomal cysteine proteases => ECO:0000305|PubMed:29386126, ECO:0000305|PubMed:37994783 |
| Chain | Residue | Details |
| A | ASN71 | |
| B | ASN71 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:37994783 |
| Chain | Residue | Details |
| A | ASN97 | |
| A | ASN132 | |
| B | ASN97 | |
| B | ASN132 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:37994783 |
| Chain | Residue | Details |
| A | ASN236 | |
| A | ASN284 | |
| A | ASN387 | |
| B | ASN236 | |
| B | ASN284 | |
| B | ASN387 |
