8V5T

Crystal structure of Alzheimers disease phospholipase D3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0002376	biological_process	immune system process
A	0003824	molecular_function	catalytic activity
A	0004518	molecular_function	nuclease activity
A	0004527	molecular_function	exonuclease activity
A	0004534	molecular_function	5'-3' RNA exonuclease activity
A	0005515	molecular_function	protein binding
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005768	cellular_component	endosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006259	biological_process	DNA metabolic process
A	0006629	biological_process	lipid metabolic process
A	0006954	biological_process	inflammatory response
A	0010008	cellular_component	endosome membrane
A	0012505	cellular_component	endomembrane system
A	0014902	biological_process	myotube differentiation
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0016787	molecular_function	hydrolase activity
A	0031901	cellular_component	early endosome membrane
A	0031902	cellular_component	late endosome membrane
A	0034164	biological_process	negative regulation of toll-like receptor 9 signaling pathway
A	0035312	molecular_function	5'-3' DNA exonuclease activity
A	0043202	cellular_component	lysosomal lumen
A	0045087	biological_process	innate immune response
A	0045145	molecular_function	single-stranded DNA 5'-3' DNA exonuclease activity
A	0070062	cellular_component	extracellular exosome
A	1900015	biological_process	regulation of cytokine production involved in inflammatory response
A	1905367	biological_process	positive regulation of intralumenal vesicle formation
B	0000139	cellular_component	Golgi membrane
B	0002376	biological_process	immune system process
B	0003824	molecular_function	catalytic activity
B	0004518	molecular_function	nuclease activity
B	0004527	molecular_function	exonuclease activity
B	0004534	molecular_function	5'-3' RNA exonuclease activity
B	0005515	molecular_function	protein binding
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0005768	cellular_component	endosome
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006259	biological_process	DNA metabolic process
B	0006629	biological_process	lipid metabolic process
B	0006954	biological_process	inflammatory response
B	0010008	cellular_component	endosome membrane
B	0012505	cellular_component	endomembrane system
B	0014902	biological_process	myotube differentiation
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0016787	molecular_function	hydrolase activity
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0034164	biological_process	negative regulation of toll-like receptor 9 signaling pathway
B	0035312	molecular_function	5'-3' DNA exonuclease activity
B	0043202	cellular_component	lysosomal lumen
B	0045087	biological_process	innate immune response
B	0045145	molecular_function	single-stranded DNA 5'-3' DNA exonuclease activity
B	0070062	cellular_component	extracellular exosome
B	1900015	biological_process	regulation of cytokine production involved in inflammatory response
B	1905367	biological_process	positive regulation of intralumenal vesicle formation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	54
Details	Domain: {"description":"PLD phosphodiesterase 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00153","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	52
Details	Domain: {"description":"PLD phosphodiesterase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00153","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00153","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00153","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"O35405","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O35405","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37994783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8Q1X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37994783","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"37994783","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---