8V5T
Crystal structure of Alzheimers disease phospholipase D3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004534 | molecular_function | 5'-3' RNA exonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005764 | cellular_component | lysosome |
| A | 0005768 | cellular_component | endosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0031902 | cellular_component | late endosome membrane |
| A | 0034164 | biological_process | negative regulation of toll-like receptor 9 signaling pathway |
| A | 0035312 | molecular_function | 5'-3' DNA exonuclease activity |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0045087 | biological_process | innate immune response |
| A | 0045145 | molecular_function | single-stranded DNA 5'-3' DNA exonuclease activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1905367 | biological_process | positive regulation of intralumenal vesicle formation |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004534 | molecular_function | 5'-3' RNA exonuclease activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005764 | cellular_component | lysosome |
| B | 0005768 | cellular_component | endosome |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0012505 | cellular_component | endomembrane system |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0031901 | cellular_component | early endosome membrane |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0034164 | biological_process | negative regulation of toll-like receptor 9 signaling pathway |
| B | 0035312 | molecular_function | 5'-3' DNA exonuclease activity |
| B | 0043202 | cellular_component | lysosomal lumen |
| B | 0045087 | biological_process | innate immune response |
| B | 0045145 | molecular_function | single-stranded DNA 5'-3' DNA exonuclease activity |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1905367 | biological_process | positive regulation of intralumenal vesicle formation |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 54 |
| Details | Domain: {"description":"PLD phosphodiesterase 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00153","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 52 |
| Details | Domain: {"description":"PLD phosphodiesterase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00153","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00153","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00153","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"O35405","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O35405","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37994783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8Q1X","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37994783","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"37994783","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
