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8V57

Complex of murine cathepsin K with bound cystatin C inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
B0006508biological_processproteolysis
B0008234molecular_functioncysteine-type peptidase activity
C0001540molecular_functionamyloid-beta binding
C0001654biological_processeye development
C0001666biological_processresponse to hypoxia
C0002020molecular_functionprotease binding
C0004866molecular_functionendopeptidase inhibitor activity
C0004869molecular_functioncysteine-type endopeptidase inhibitor activity
C0005576cellular_componentextracellular region
C0005604cellular_componentbasement membrane
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005771cellular_componentmultivesicular body
C0005794cellular_componentGolgi apparatus
C0005886cellular_componentplasma membrane
C0006952biological_processdefense response
C0007431biological_processsalivary gland development
C0007566biological_processembryo implantation
C0008284biological_processpositive regulation of cell population proliferation
C0008584biological_processmale gonad development
C0009410biological_processresponse to xenobiotic stimulus
C0009636biological_processresponse to toxic substance
C0009743biological_processresponse to carbohydrate
C0010711biological_processnegative regulation of collagen catabolic process
C0010716biological_processnegative regulation of extracellular matrix disassembly
C0030414molecular_functionpeptidase inhibitor activity
C0030424cellular_componentaxon
C0031012cellular_componentextracellular matrix
C0031667biological_processresponse to nutrient levels
C0031965cellular_componentnuclear membrane
C0031982cellular_componentvesicle
C0032355biological_processresponse to estradiol
C0034103biological_processregulation of tissue remodeling
C0034599biological_processcellular response to oxidative stress
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043025cellular_componentneuronal cell body
C0043292cellular_componentcontractile muscle fiber
C0045740biological_processpositive regulation of DNA replication
C0045861biological_processnegative regulation of proteolysis
C0048471cellular_componentperinuclear region of cytoplasm
C0048678biological_processresponse to axon injury
C0060009biological_processSertoli cell development
C0060311biological_processnegative regulation of elastin catabolic process
C0060313biological_processnegative regulation of blood vessel remodeling
C0070301biological_processcellular response to hydrogen peroxide
C0097435biological_processsupramolecular fiber organization
D0001540molecular_functionamyloid-beta binding
D0001654biological_processeye development
D0001666biological_processresponse to hypoxia
D0002020molecular_functionprotease binding
D0004866molecular_functionendopeptidase inhibitor activity
D0004869molecular_functioncysteine-type endopeptidase inhibitor activity
D0005576cellular_componentextracellular region
D0005604cellular_componentbasement membrane
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0005771cellular_componentmultivesicular body
D0005794cellular_componentGolgi apparatus
D0005886cellular_componentplasma membrane
D0006952biological_processdefense response
D0007431biological_processsalivary gland development
D0007566biological_processembryo implantation
D0008284biological_processpositive regulation of cell population proliferation
D0008584biological_processmale gonad development
D0009410biological_processresponse to xenobiotic stimulus
D0009636biological_processresponse to toxic substance
D0009743biological_processresponse to carbohydrate
D0010711biological_processnegative regulation of collagen catabolic process
D0010716biological_processnegative regulation of extracellular matrix disassembly
D0030414molecular_functionpeptidase inhibitor activity
D0030424cellular_componentaxon
D0031012cellular_componentextracellular matrix
D0031667biological_processresponse to nutrient levels
D0031965cellular_componentnuclear membrane
D0031982cellular_componentvesicle
D0032355biological_processresponse to estradiol
D0034103biological_processregulation of tissue remodeling
D0034599biological_processcellular response to oxidative stress
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043025cellular_componentneuronal cell body
D0043292cellular_componentcontractile muscle fiber
D0045740biological_processpositive regulation of DNA replication
D0045861biological_processnegative regulation of proteolysis
D0048471cellular_componentperinuclear region of cytoplasm
D0048678biological_processresponse to axon injury
D0060009biological_processSertoli cell development
D0060311biological_processnegative regulation of elastin catabolic process
D0060313biological_processnegative regulation of blood vessel remodeling
D0070301biological_processcellular response to hydrogen peroxide
D0097435biological_processsupramolecular fiber organization
Functional Information from PROSITE/UniProt
site_idPS00139
Number of Residues12
DetailsTHIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSS
ChainResidueDetails
AGLN19-SER30

site_idPS00287
Number of Residues14
DetailsCYSTATIN Cysteine proteases inhibitors signature. KQLVAGVNYfLDVE
ChainResidueDetails
CLYS54-GLU67

site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. VNHAVLVVGYG
ChainResidueDetails
AVAL160-GLY170

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsActive site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues8
DetailsMotif: {"description":"Secondary area of contact"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsSite: {"description":"Reactive site"}
ChainResidueDetails

250359

PDB entries from 2026-03-11

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