8V2O
Cryo-EM Structure of Wildtype Smooth Muscle Gamma Actin (ACTG2)
Functional Information from PROSITE/UniProt
| site_id | PS00406 |
| Number of Residues | 11 |
| Details | ACTINS_1 Actins signature 1. YVGDEAQs.KRG |
| Chain | Residue | Details |
| A | TYR53-GLY63 |
| site_id | PS00432 |
| Number of Residues | 9 |
| Details | ACTINS_2 Actins signature 2. WISKpEYDE |
| Chain | Residue | Details |
| A | TRP356-GLU364 |
| site_id | PS01132 |
| Number of Residues | 13 |
| Details | ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR |
| Chain | Residue | Details |
| A | LEU104-ARG116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | MOD_RES: N-acetylcysteine; in intermediate form => ECO:0000250|UniProtKB:P62737 |
| Chain | Residue | Details |
| A | CYS1 | |
| B | CYS1 | |
| C | CYS1 | |
| D | CYS1 | |
| E | CYS1 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | MOD_RES: N-acetylglutamate; in Actin, gamma-enteric smooth muscle => ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | GLU2 | |
| B | GLU2 | |
| C | GLU2 | |
| D | GLU2 | |
| E | GLU2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | MOD_RES: Methionine (R)-sulfoxide => ECO:0000250|UniProtKB:P63268 |
| Chain | Residue | Details |
| A | MET44 | |
| A | MET47 | |
| B | MET44 | |
| B | MET47 | |
| C | MET44 | |
| C | MET47 | |
| D | MET44 | |
| D | MET47 | |
| E | MET44 | |
| E | MET47 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | MOD_RES: Tele-methylhistidine => ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:31993215 |
| Chain | Residue | Details |
| A | HIC73 | |
| B | HIC73 | |
| C | HIC73 | |
| D | HIC73 | |
| E | HIC73 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | CROSSLNK: Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-271); by Vibrio toxins RtxA and VgrG1 => ECO:0000250|UniProtKB:P60709 |
| Chain | Residue | Details |
| A | LYS50 | |
| B | LYS50 | |
| C | LYS50 | |
| D | LYS50 | |
| E | LYS50 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | CROSSLNK: Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-51); by Vibrio toxins RtxA and VgrG1 => ECO:0000250|UniProtKB:P60709 |
| Chain | Residue | Details |
| A | GLU270 | |
| B | GLU270 | |
| C | GLU270 | |
| D | GLU270 | |
| E | GLU270 |
