8V1F

TMPRSS2 complexed with the noncovalent inhibitor 6-amidino-2-napthol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0016020	cellular_component	membrane
D	0004252	molecular_function	serine-type endopeptidase activity
D	0006508	biological_process	proteolysis

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC

Chain	Residue	Details
B	VAL292-CYS297

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV

Chain	Residue	Details
B	ASP435-VAL446

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	186
Details	Domain: {"description":"SRCR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XYD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HD8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XYD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8S0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8S0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	472
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XYD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HD8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	260
Details	Region: {"description":"HKU1-CoV S protein-binding","evidences":[{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964328","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11245484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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