Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8UX1

Cryo-EM structure of Ran bound to RCC1 and the nucleosome core particle

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005700	cellular_component	polytene chromosome
A	0006334	biological_process	nucleosome assembly
A	0030527	molecular_function	structural constituent of chromatin
A	0031492	molecular_function	nucleosomal DNA binding
A	0035059	cellular_component	RCAF complex
A	0046982	molecular_function	protein heterodimerization activity
B	0000228	cellular_component	nuclear chromosome
B	0000786	cellular_component	nucleosome
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006334	biological_process	nucleosome assembly
B	0030527	molecular_function	structural constituent of chromatin
B	0035059	cellular_component	RCAF complex
B	0046982	molecular_function	protein heterodimerization activity
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005700	cellular_component	polytene chromosome
C	0005704	cellular_component	polytene chromosome band
C	0006325	biological_process	chromatin organization
C	0006334	biological_process	nucleosome assembly
C	0007526	biological_process	larval somatic muscle development
C	0030527	molecular_function	structural constituent of chromatin
C	0031492	molecular_function	nucleosomal DNA binding
C	0031507	biological_process	heterochromatin formation
C	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006325	biological_process	chromatin organization
D	0030527	molecular_function	structural constituent of chromatin
D	0044877	molecular_function	protein-containing complex binding
D	0046982	molecular_function	protein heterodimerization activity
E	0000785	cellular_component	chromatin
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0005700	cellular_component	polytene chromosome
E	0006334	biological_process	nucleosome assembly
E	0030527	molecular_function	structural constituent of chromatin
E	0031492	molecular_function	nucleosomal DNA binding
E	0035059	cellular_component	RCAF complex
E	0046982	molecular_function	protein heterodimerization activity
F	0000228	cellular_component	nuclear chromosome
F	0000786	cellular_component	nucleosome
F	0003676	molecular_function	nucleic acid binding
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006334	biological_process	nucleosome assembly
F	0030527	molecular_function	structural constituent of chromatin
F	0035059	cellular_component	RCAF complex
F	0046982	molecular_function	protein heterodimerization activity
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0005700	cellular_component	polytene chromosome
G	0005704	cellular_component	polytene chromosome band
G	0006325	biological_process	chromatin organization
G	0006334	biological_process	nucleosome assembly
G	0007526	biological_process	larval somatic muscle development
G	0030527	molecular_function	structural constituent of chromatin
G	0031492	molecular_function	nucleosomal DNA binding
G	0031507	biological_process	heterochromatin formation
G	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0006325	biological_process	chromatin organization
H	0030527	molecular_function	structural constituent of chromatin
H	0044877	molecular_function	protein-containing complex binding
H	0046982	molecular_function	protein heterodimerization activity
K	0000054	biological_process	ribosomal subunit export from nucleus
K	0000055	biological_process	ribosomal large subunit export from nucleus
K	0000056	biological_process	ribosomal small subunit export from nucleus
K	0000070	biological_process	mitotic sister chromatid segregation
K	0000278	biological_process	mitotic cell cycle
K	0000287	molecular_function	magnesium ion binding
K	0000785	cellular_component	chromatin
K	0001673	cellular_component	male germ cell nucleus
K	0002177	cellular_component	manchette
K	0003682	molecular_function	chromatin binding
K	0003723	molecular_function	RNA binding
K	0003924	molecular_function	GTPase activity
K	0003925	molecular_function	G protein activity
K	0005049	molecular_function	nuclear export signal receptor activity
K	0005515	molecular_function	protein binding
K	0005525	molecular_function	GTP binding
K	0005634	cellular_component	nucleus
K	0005635	cellular_component	nuclear envelope
K	0005643	cellular_component	nuclear pore
K	0005654	cellular_component	nucleoplasm
K	0005730	cellular_component	nucleolus
K	0005737	cellular_component	cytoplasm
K	0005814	cellular_component	centriole
K	0005829	cellular_component	cytosol
K	0006259	biological_process	DNA metabolic process
K	0006606	biological_process	protein import into nucleus
K	0006611	biological_process	protein export from nucleus
K	0006913	biological_process	nucleocytoplasmic transport
K	0007052	biological_process	mitotic spindle organization
K	0007286	biological_process	spermatid development
K	0008104	biological_process	protein localization
K	0014070	biological_process	response to organic cyclic compound
K	0015031	biological_process	protein transport
K	0016020	cellular_component	membrane
K	0016032	biological_process	viral process
K	0016787	molecular_function	hydrolase activity
K	0019003	molecular_function	GDP binding
K	0019904	molecular_function	protein domain specific binding
K	0021766	biological_process	hippocampus development
K	0030036	biological_process	actin cytoskeleton organization
K	0030496	cellular_component	midbody
K	0031503	biological_process	protein-containing complex localization
K	0032092	biological_process	positive regulation of protein binding
K	0032991	cellular_component	protein-containing complex
K	0035281	biological_process	pre-miRNA export from nucleus
K	0036126	cellular_component	sperm flagellum
K	0042307	biological_process	positive regulation of protein import into nucleus
K	0042470	cellular_component	melanosome
K	0042565	cellular_component	RNA nuclear export complex
K	0044877	molecular_function	protein-containing complex binding
K	0045296	molecular_function	cadherin binding
K	0045505	molecular_function	dynein intermediate chain binding
K	0046039	biological_process	GTP metabolic process
K	0046872	molecular_function	metal ion binding
K	0046982	molecular_function	protein heterodimerization activity
K	0051301	biological_process	cell division
K	0055037	cellular_component	recycling endosome
K	0061015	biological_process	snRNA import into nucleus
K	0061676	molecular_function	importin-alpha family protein binding
K	0070062	cellular_component	extracellular exosome
K	0070883	molecular_function	pre-miRNA binding
K	0071389	biological_process	cellular response to mineralocorticoid stimulus
K	0090543	cellular_component	Flemming body
K	1902570	biological_process	protein localization to nucleolus
L	0000082	biological_process	G1/S transition of mitotic cell cycle
L	0000785	cellular_component	chromatin
L	0000794	cellular_component	condensed nuclear chromosome
L	0003677	molecular_function	DNA binding
L	0003682	molecular_function	chromatin binding
L	0005085	molecular_function	guanyl-nucleotide exchange factor activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0005737	cellular_component	cytoplasm
L	0007052	biological_process	mitotic spindle organization
L	0007059	biological_process	chromosome segregation
L	0007084	biological_process	mitotic nuclear membrane reassembly
L	0007088	biological_process	regulation of mitotic nuclear division
L	0016032	biological_process	viral process
L	0031267	molecular_function	small GTPase binding
L	0031491	molecular_function	nucleosome binding
L	0031492	molecular_function	nucleosomal DNA binding
L	0032991	cellular_component	protein-containing complex
L	0042393	molecular_function	histone binding
L	0043199	molecular_function	sulfate binding
L	0046982	molecular_function	protein heterodimerization activity
L	0051225	biological_process	spindle assembly
L	0051301	biological_process	cell division

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111

site_id	PS00625
Number of Residues	12
Details	RCC1_1 Regulator of chromosome condensation (RCC1) signature 1. GcNDegALGRdT

Chain	Residue	Details
L	GLY92-THR103

site_id	PS00626
Number of Residues	11
Details	RCC1_2 Regulator of chromosome condensation (RCC1) signature 2. VSAGdSHTAAL

Chain	Residue	Details
L	VAL124-LEU134
L	VAL177-LEU187
L	PHE299-MET309
L	VAL404-LEU414

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by Haspin => ECO:0000269\|PubMed:32750047

Chain	Residue	Details
A	THR3
E	THR3

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269\|PubMed:14732680, ECO:0000269\|PubMed:15175259

Chain	Residue	Details
A	LYS4
E	LYS4
D	LYS117
H	LYS43
H	LYS113
H	LYS117

site_id	SWS_FT_FI3
Number of Residues	10
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269\|PubMed:14732680

Chain	Residue	Details
A	LYS9
E	LYS37
A	LYS14
A	LYS27
A	LYS36
A	LYS37
E	LYS9
E	LYS14
E	LYS27
E	LYS36

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:11114889, ECO:0000269\|PubMed:11266459, ECO:0000269\|PubMed:11371341, ECO:0000269\|PubMed:12514098, ECO:0000269\|PubMed:15175259

Chain	Residue	Details
A	SER10
E	SER10
H	LYS117
F	THR82

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:14732680

Chain	Residue	Details
A	LYS18
A	LYS23
E	LYS18
E	LYS23

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:22389435

Chain	Residue	Details
A	LYS56
E	LYS56

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269\|PubMed:22389435

Chain	Residue	Details
A	LYS79
E	LYS79

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
K	THR24

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:31075303

Chain	Residue	Details
K	LYS37

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
K	LYS60
K	LYS99

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
K	LYS71

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:29040603

Chain	Residue	Details
K	LYS134

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P62827

Chain	Residue	Details
K	LYS159

site_id	SWS_FT_FI14
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate

Chain	Residue	Details
K	LYS71

site_id	SWS_FT_FI15
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
K	LYS152

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)